TTC19 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	27 studies	29% ± 12%	Explore
astrocyte	15 studies	37% ± 12%	Explore
T cell	13 studies	22% ± 6%	Explore
fibroblast	13 studies	25% ± 9%	Explore
natural killer cell	12 studies	20% ± 3%	Explore
endothelial cell of lymphatic vessel	11 studies	26% ± 9%	Explore
basal cell	11 studies	25% ± 14%	Explore
glutamatergic neuron	10 studies	45% ± 26%	Explore
type I pneumocyte	9 studies	22% ± 5%	Explore
GABAergic neuron	9 studies	41% ± 23%	Explore
adipocyte	9 studies	30% ± 10%	Explore
oligodendrocyte precursor cell	9 studies	32% ± 16%	Explore
B cell	8 studies	23% ± 4%	Explore
dendritic cell	8 studies	23% ± 10%	Explore
mast cell	8 studies	20% ± 1%	Explore
CD4-positive, alpha-beta T cell	8 studies	23% ± 5%	Explore
pericyte	8 studies	23% ± 6%	Explore
smooth muscle cell	8 studies	21% ± 5%	Explore
ciliated cell	8 studies	25% ± 9%	Explore
oligodendrocyte	8 studies	30% ± 11%	Explore
CD8-positive, alpha-beta T cell	7 studies	21% ± 4%	Explore
capillary endothelial cell	7 studies	20% ± 4%	Explore
retinal rod cell	7 studies	23% ± 5%	Explore
macrophage	7 studies	26% ± 6%	Explore
epithelial cell	7 studies	42% ± 18%	Explore
type II pneumocyte	7 studies	24% ± 7%	Explore
effector memory CD8-positive, alpha-beta T cell	6 studies	21% ± 4%	Explore
mature NK T cell	6 studies	19% ± 1%	Explore
gamma-delta T cell	6 studies	25% ± 6%	Explore
amacrine cell	6 studies	36% ± 11%	Explore
interneuron	6 studies	46% ± 25%	Explore
neuron	6 studies	40% ± 17%	Explore
club cell	6 studies	26% ± 9%	Explore
vein endothelial cell	6 studies	24% ± 15%	Explore
endothelial cell of vascular tree	6 studies	27% ± 14%	Explore
monocyte	5 studies	23% ± 9%	Explore
CD16-negative, CD56-bright natural killer cell, human	5 studies	21% ± 4%	Explore
endothelial cell of artery	5 studies	18% ± 1%	Explore
microglial cell	5 studies	26% ± 8%	Explore
retina horizontal cell	5 studies	31% ± 10%	Explore
retinal cone cell	5 studies	32% ± 11%	Explore
Mueller cell	5 studies	31% ± 12%	Explore
regulatory T cell	5 studies	17% ± 1%	Explore
goblet cell	5 studies	26% ± 15%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	4 studies	23% ± 4%	Explore
memory B cell	4 studies	19% ± 3%	Explore
retinal bipolar neuron	4 studies	33% ± 10%	Explore
retinal ganglion cell	4 studies	44% ± 17%	Explore
myeloid cell	4 studies	24% ± 4%	Explore
cardiac muscle cell	4 studies	22% ± 3%	Explore
respiratory goblet cell	4 studies	23% ± 7%	Explore
CD8-positive, alpha-beta memory T cell	4 studies	20% ± 2%	Explore
secretory cell	3 studies	21% ± 2%	Explore
leukocyte	3 studies	20% ± 3%	Explore
CD16-positive, CD56-dim natural killer cell, human	3 studies	21% ± 3%	Explore
conventional dendritic cell	3 studies	30% ± 10%	Explore
GABAergic interneuron	3 studies	25% ± 1%	Explore
glial cell	3 studies	24% ± 10%	Explore
granule cell	3 studies	31% ± 12%	Explore
myofibroblast cell	3 studies	23% ± 8%	Explore
retinal pigment epithelial cell	3 studies	40% ± 19%	Explore
mesothelial cell	3 studies	26% ± 9%	Explore
lymphocyte	3 studies	29% ± 4%	Explore
OFF-bipolar cell	3 studies	22% ± 2%	Explore
rod bipolar cell	3 studies	35% ± 3%	Explore
innate lymphoid cell	3 studies	21% ± 4%	Explore
luminal hormone-sensing cell of mammary gland	3 studies	19% ± 4%	Explore
muscle cell	3 studies	38% ± 16%	Explore
abnormal cell	3 studies	27% ± 12%	Explore
connective tissue cell	3 studies	20% ± 4%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	29% ± 13%	Explore
intestinal crypt stem cell	3 studies	22% ± 2%	Explore
alveolar macrophage	3 studies	26% ± 6%	Explore
T follicular helper cell	3 studies	21% ± 4%	Explore
transit amplifying cell	3 studies	34% ± 23%	Explore
plasmacytoid dendritic cell	3 studies	23% ± 6%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	14 studies	36% ± 21%	Explore
lung	9 studies	23% ± 5%	Explore
eye	8 studies	30% ± 11%	Explore
peripheral blood	5 studies	26% ± 4%	Explore
heart	4 studies	21% ± 2%	Explore
intestine	3 studies	22% ± 8%	Explore
adipose	3 studies	27% ± 5%	Explore
liver	3 studies	28% ± 12%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	2141.75	1445 / 1445	100%	22.80	183 / 183
pancreas	100%	2081.72	328 / 328	100%	24.97	178 / 178
brain	100%	3676.55	2639 / 2642	100%	41.72	705 / 705
thymus	100%	3523.69	653 / 653	100%	37.58	604 / 605
lung	100%	2839.62	578 / 578	100%	23.51	1153 / 1155
intestine	100%	2715.28	966 / 966	100%	29.08	526 / 527
prostate	100%	3271.11	245 / 245	100%	39.91	501 / 502
uterus	100%	2726.12	170 / 170	100%	21.69	458 / 459
ovary	100%	2893.56	180 / 180	100%	19.61	429 / 430
stomach	100%	2118.43	359 / 359	100%	26.06	285 / 286
breast	100%	2986.13	459 / 459	100%	36.18	1113 / 1118
kidney	100%	3120.66	89 / 89	99%	27.19	894 / 901
bladder	100%	2314.81	21 / 21	99%	23.78	499 / 504
adrenal gland	100%	3867.26	258 / 258	98%	27.03	225 / 230
skin	100%	2834.75	1809 / 1809	97%	26.55	460 / 472
liver	100%	1954.42	226 / 226	92%	12.84	375 / 406
adipose	100%	2457.74	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	17.46	29 / 29
muscle	100%	2024.87	803 / 803	0%	0	0 / 0
spleen	100%	2415.28	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	20.62	45 / 45
ureter	0%	0	0 / 0	100%	7.69	1 / 1
blood vessel	100%	1877.23	1334 / 1335	0%	0	0 / 0
heart	100%	2069.95	857 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	93%	17.99	74 / 80
peripheral blood	38%	630.96	356 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0034551	Biological process	mitochondrial respiratory chain complex III assembly
GO_0000281	Biological process	mitotic cytokinesis
GO_0070469	Cellular component	respirasome
GO_0005813	Cellular component	centrosome
GO_0030496	Cellular component	midbody
GO_0005743	Cellular component	mitochondrial inner membrane
GO_0005739	Cellular component	mitochondrion
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	TTC19
Protein name	Tetratricopeptide repeat domain 19 Tetratricopeptide repeat protein 19, mitochondrial (TPR repeat protein 19)
Synonyms
Description	FUNCTION: Required for the preservation of the structural and functional integrity of mitochondrial respiratory complex III by allowing the physiological turnover of the Rieske protein UQCRFS1 . Involved in the clearance of UQCRFS1 N-terminal fragments, which are produced upon incorporation of UQCRFS1 into the complex III and whose presence is detrimental for its catalytic activity . .
Accessions	ENST00000475723.5 K7EKS0 K7EKH7 Q6DKK2 ENST00000470649.1 ENST00000261647.10 ENST00000470399.1 K7ERR1 K7ELX2 K7EJA1 ENST00000578103.1 ENST00000466729.5

TTC19 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review