TSPYL2 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	23 studies	27% ± 10%	Explore
CD8-positive, alpha-beta T cell	23 studies	28% ± 9%	Explore
CD4-positive, alpha-beta T cell	21 studies	29% ± 8%	Explore
B cell	19 studies	22% ± 7%	Explore
plasmacytoid dendritic cell	19 studies	33% ± 12%	Explore
mast cell	18 studies	29% ± 9%	Explore
T cell	17 studies	33% ± 16%	Explore
fibroblast	17 studies	26% ± 10%	Explore
smooth muscle cell	17 studies	23% ± 6%	Explore
regulatory T cell	17 studies	31% ± 10%	Explore
pericyte	14 studies	30% ± 10%	Explore
gamma-delta T cell	12 studies	37% ± 15%	Explore
endothelial cell	12 studies	21% ± 7%	Explore
naive B cell	11 studies	22% ± 5%	Explore
mucosal invariant T cell	11 studies	27% ± 11%	Explore
CD16-positive, CD56-dim natural killer cell, human	10 studies	27% ± 8%	Explore
mature NK T cell	10 studies	26% ± 8%	Explore
memory B cell	10 studies	22% ± 5%	Explore
CD16-negative, CD56-bright natural killer cell, human	9 studies	26% ± 8%	Explore
CD4-positive, alpha-beta memory T cell	8 studies	31% ± 12%	Explore
CD8-positive, alpha-beta memory T cell	8 studies	39% ± 13%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	7 studies	26% ± 7%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	7 studies	27% ± 7%	Explore
conventional dendritic cell	7 studies	23% ± 7%	Explore
glutamatergic neuron	7 studies	32% ± 18%	Explore
innate lymphoid cell	7 studies	26% ± 10%	Explore
effector memory CD8-positive, alpha-beta T cell	6 studies	39% ± 10%	Explore
T follicular helper cell	6 studies	36% ± 14%	Explore
dendritic cell	5 studies	24% ± 8%	Explore
GABAergic neuron	5 studies	38% ± 20%	Explore
myofibroblast cell	5 studies	27% ± 7%	Explore
effector CD8-positive, alpha-beta T cell	4 studies	32% ± 11%	Explore
leukocyte	4 studies	27% ± 5%	Explore
amacrine cell	4 studies	25% ± 6%	Explore
epithelial cell	4 studies	27% ± 14%	Explore
oligodendrocyte precursor cell	4 studies	23% ± 9%	Explore
plasma cell	3 studies	21% ± 7%	Explore
endothelial cell of lymphatic vessel	3 studies	20% ± 2%	Explore
type B pancreatic cell	3 studies	32% ± 7%	Explore
effector CD4-positive, alpha-beta T cell	3 studies	40% ± 9%	Explore
retinal bipolar neuron	3 studies	23% ± 5%	Explore
macrophage	3 studies	23% ± 6%	Explore
connective tissue cell	3 studies	24% ± 9%	Explore
basal cell	3 studies	20% ± 2%	Explore
CD4-positive helper T cell	3 studies	41% ± 13%	Explore
effector memory CD4-positive, alpha-beta T cell	3 studies	40% ± 13%	Explore
granulocyte	3 studies	24% ± 1%	Explore
muscle cell	3 studies	27% ± 3%	Explore
group 3 innate lymphoid cell	3 studies	43% ± 13%	Explore
interneuron	3 studies	51% ± 19%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	9 studies	20% ± 4%	Explore
brain	7 studies	29% ± 17%	Explore
lung	4 studies	23% ± 6%	Explore
lymph node	4 studies	26% ± 8%	Explore
intestine	3 studies	21% ± 4%	Explore
eye	3 studies	24% ± 9%	Explore
uterus	3 studies	23% ± 6%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
prostate	100%	20614.44	244 / 245	100%	38.26	502 / 502
adrenal gland	100%	19266.90	258 / 258	100%	114.82	229 / 230
thymus	100%	13595.38	651 / 653	100%	42.36	602 / 605
uterus	99%	20638.83	169 / 170	97%	23.77	446 / 459
breast	99%	10206.51	454 / 459	97%	20.61	1085 / 1118
brain	96%	20599.21	2529 / 2642	100%	82.94	705 / 705
bladder	100%	17504.86	21 / 21	91%	16.48	457 / 504
ovary	100%	50804.80	180 / 180	90%	13.14	386 / 430
lung	99%	10771.54	570 / 578	91%	17.90	1052 / 1155
pancreas	81%	5295.76	267 / 328	98%	27.14	175 / 178
intestine	92%	12228.08	888 / 966	83%	11.12	436 / 527
skin	74%	5027.56	1330 / 1809	99%	32.92	469 / 472
stomach	87%	10234.44	313 / 359	76%	9.62	217 / 286
kidney	73%	4986.63	65 / 89	88%	21.96	793 / 901
esophagus	82%	13304.28	1185 / 1445	72%	8.42	132 / 183
lymph node	0%	0	0 / 0	100%	32.53	29 / 29
ureter	0%	0	0 / 0	100%	9.09	1 / 1
blood vessel	100%	18730.20	1334 / 1335	0%	0	0 / 0
liver	29%	1763.68	65 / 226	70%	11.02	286 / 406
spleen	99%	12210.38	239 / 241	0%	0	0 / 0
adipose	99%	9712.49	1188 / 1204	0%	0	0 / 0
tonsil	0%	0	0 / 0	96%	15.90	43 / 45
heart	87%	7435.64	749 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	84%	11.28	67 / 80
muscle	76%	7132.53	612 / 803	0%	0	0 / 0
peripheral blood	35%	2452.82	326 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0009966	Biological process	regulation of signal transduction
GO_0045859	Biological process	regulation of protein kinase activity
GO_0008156	Biological process	negative regulation of DNA replication
GO_0045786	Biological process	negative regulation of cell cycle
GO_0006334	Biological process	nucleosome assembly
GO_0030308	Biological process	negative regulation of cell growth
GO_0005730	Cellular component	nucleolus
GO_0005654	Cellular component	nucleoplasm
GO_0000785	Cellular component	chromatin
GO_0005737	Cellular component	cytoplasm
GO_0005634	Cellular component	nucleus
GO_0000182	Molecular function	rDNA binding
GO_0005515	Molecular function	protein binding
GO_0042393	Molecular function	histone binding
GO_0003682	Molecular function	chromatin binding

IV. Literature review

[source]

Gene name	TSPYL2
Protein name	TSPY like 2 Testis-specific Y-encoded-like protein 2 (TSPY-like protein 2) (Cell division autoantigen 1) (Cutaneous T-cell lymphoma-associated antigen se20-4) (CTCL-associated antigen se20-4) (Differentially-expressed nucleolar TGF-beta1 target protein) (Nuclear protein of 79 kDa) (NP79)
Synonyms	TSPX HRIHFB2216 CDA1 DENTT
Description	FUNCTION: Part of the CASK/TBR1/TSPYL2 transcriptional complex which modulates gene expression in response to neuronal synaptic activity, probably by facilitating nucleosome assembly. May inhibit cell proliferation by inducing p53-dependent CDKN1A expression. .
Accessions	Q9H2G4 ENST00000579390.1 J3KST2 ENST00000578306.5 ENST00000375442.8 J3KS33

TSPYL2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review