TSPAN14 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	42 studies	30% ± 11%	Explore
natural killer cell	21 studies	21% ± 3%	Explore
non-classical monocyte	20 studies	36% ± 14%	Explore
endothelial cell of lymphatic vessel	18 studies	31% ± 12%	Explore
regulatory T cell	18 studies	22% ± 5%	Explore
classical monocyte	17 studies	23% ± 11%	Explore
macrophage	16 studies	25% ± 10%	Explore
CD4-positive, alpha-beta T cell	15 studies	24% ± 6%	Explore
capillary endothelial cell	15 studies	32% ± 6%	Explore
CD16-positive, CD56-dim natural killer cell, human	14 studies	25% ± 7%	Explore
CD8-positive, alpha-beta T cell	14 studies	23% ± 5%	Explore
vein endothelial cell	13 studies	25% ± 12%	Explore
T cell	12 studies	19% ± 3%	Explore
monocyte	12 studies	24% ± 7%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	10 studies	23% ± 5%	Explore
endothelial cell of artery	10 studies	25% ± 5%	Explore
microglial cell	10 studies	37% ± 15%	Explore
basal cell	9 studies	27% ± 15%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	9 studies	23% ± 6%	Explore
CD8-positive, alpha-beta memory T cell	8 studies	20% ± 5%	Explore
endothelial cell of vascular tree	8 studies	28% ± 15%	Explore
gamma-delta T cell	8 studies	19% ± 2%	Explore
CD4-positive, alpha-beta memory T cell	7 studies	21% ± 5%	Explore
effector memory CD8-positive, alpha-beta T cell	7 studies	20% ± 3%	Explore
mature NK T cell	7 studies	21% ± 3%	Explore
epithelial cell	7 studies	38% ± 22%	Explore
lymphocyte	6 studies	28% ± 9%	Explore
myeloid cell	6 studies	33% ± 8%	Explore
adipocyte	6 studies	27% ± 6%	Explore
respiratory goblet cell	5 studies	22% ± 7%	Explore
CD16-negative, CD56-bright natural killer cell, human	5 studies	19% ± 2%	Explore
pericyte	5 studies	29% ± 7%	Explore
pro-B cell	5 studies	37% ± 10%	Explore
T follicular helper cell	5 studies	20% ± 2%	Explore
glutamatergic neuron	5 studies	27% ± 8%	Explore
secretory cell	4 studies	31% ± 13%	Explore
squamous epithelial cell	4 studies	41% ± 22%	Explore
exhausted T cell	4 studies	24% ± 8%	Explore
mononuclear phagocyte	4 studies	21% ± 3%	Explore
GABAergic neuron	4 studies	19% ± 2%	Explore
enteroendocrine cell	4 studies	25% ± 5%	Explore
alveolar macrophage	4 studies	34% ± 14%	Explore
goblet cell	4 studies	30% ± 9%	Explore
astrocyte	4 studies	34% ± 16%	Explore
conventional dendritic cell	3 studies	29% ± 14%	Explore
glomerular endothelial cell	3 studies	33% ± 5%	Explore
club cell	3 studies	24% ± 5%	Explore
precursor B cell	3 studies	27% ± 10%	Explore
ciliated cell	3 studies	29% ± 10%	Explore
effector CD8-positive, alpha-beta T cell	3 studies	21% ± 4%	Explore
endothelial cell of sinusoid	3 studies	35% ± 14%	Explore
type I pneumocyte	3 studies	16% ± 2%	Explore
type II pneumocyte	3 studies	21% ± 4%	Explore
dendritic cell	3 studies	24% ± 11%	Explore
effector memory CD4-positive, alpha-beta T cell	3 studies	25% ± 6%	Explore
transit amplifying cell	3 studies	33% ± 25%	Explore
neuron	3 studies	24% ± 1%	Explore
double negative thymocyte	3 studies	18% ± 0%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	3 studies	20% ± 4%	Explore
interneuron	3 studies	23% ± 1%	Explore
oligodendrocyte	3 studies	23% ± 7%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	12 studies	24% ± 8%	Explore
lung	9 studies	22% ± 8%	Explore
brain	9 studies	22% ± 5%	Explore
adipose	4 studies	22% ± 5%	Explore
bone marrow	3 studies	19% ± 4%	Explore
intestine	3 studies	18% ± 2%	Explore
liver	3 studies	25% ± 7%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
intestine	100%	5399.84	966 / 966	100%	20.84	527 / 527
ovary	100%	6737.13	180 / 180	100%	28.86	430 / 430
prostate	100%	7034.39	245 / 245	100%	26.55	502 / 502
uterus	100%	6384.62	170 / 170	100%	32.58	459 / 459
esophagus	100%	8107.07	1444 / 1445	100%	34.35	183 / 183
lung	100%	12892.81	578 / 578	100%	27.62	1153 / 1155
skin	100%	9133.08	1808 / 1809	100%	52.56	471 / 472
thymus	100%	8772.50	652 / 653	100%	20.27	604 / 605
bladder	100%	7952.71	21 / 21	100%	33.48	502 / 504
breast	100%	13297.86	459 / 459	99%	25.92	1112 / 1118
kidney	100%	6789.60	89 / 89	99%	25.85	889 / 901
stomach	98%	3561.18	352 / 359	99%	19.39	284 / 286
pancreas	93%	2681.85	304 / 328	98%	24.32	174 / 178
brain	85%	2915.69	2233 / 2642	100%	19.27	704 / 705
adrenal gland	100%	3478.10	257 / 258	72%	7.53	165 / 230
liver	79%	2063.06	179 / 226	83%	9.73	336 / 406
adipose	100%	14365.58	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	40.27	80 / 80
spleen	100%	9869.89	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	38.67	45 / 45
ureter	0%	0	0 / 0	100%	30.31	1 / 1
peripheral blood	99%	10817.96	921 / 929	0%	0	0 / 0
blood vessel	98%	3893.24	1309 / 1335	0%	0	0 / 0
heart	97%	3787.43	836 / 861	0%	0	0 / 0
lymph node	0%	0	0 / 0	97%	17.26	28 / 29
muscle	79%	1900.66	638 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0045747	Biological process	positive regulation of Notch signaling pathway
GO_0072659	Biological process	protein localization to plasma membrane
GO_0051604	Biological process	protein maturation
GO_0009986	Cellular component	cell surface
GO_0005788	Cellular component	endoplasmic reticulum lumen
GO_0070821	Cellular component	tertiary granule membrane
GO_0035579	Cellular component	specific granule membrane
GO_0005886	Cellular component	plasma membrane
GO_0097197	Cellular component	tetraspanin-enriched microdomain
GO_0019899	Molecular function	enzyme binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	TSPAN14
Protein name	Tetraspanin Tetraspanin-14 (Tspan-14) (DC-TM4F2) (Transmembrane 4 superfamily member 14)
Synonyms	TM4SF14
Description	FUNCTION: Part of TspanC8 subgroup, composed of 6 members that interact with the transmembrane metalloprotease ADAM10. This interaction is required for ADAM10 exit from the endoplasmic reticulum and for enzymatic maturation and trafficking to the cell surface as well as substrate specificity. Different TspanC8/ADAM10 complexes have distinct substrates . Negatively regulates ADAM10-mediated cleavage of GP6 (By similarity). Promotes ADAM10-mediated cleavage of CDH5 (By similarity). .
Accessions	H7BXY6 A6NEP9 ENST00000372164.7 [Q8NG11-2] ENST00000481124.5 [Q8NG11-3] ENST00000429989.8 [Q8NG11-1] Q8NG11 ENST00000616406.1 [Q8NG11-2] ENST00000372157.6 ENST00000372156.5 [Q8NG11-1] ENST00000341863.10 ENST00000372158.6 [Q8NG11-1]

TSPAN14 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review