Name | Number of supported studies | Average coverage | |
---|---|---|---|
lung | 12 studies | 34% ± 19% | |
eye | 10 studies | 29% ± 9% | |
intestine | 9 studies | 47% ± 22% | |
brain | 8 studies | 30% ± 14% | |
heart | 7 studies | 49% ± 19% | |
kidney | 6 studies | 36% ± 10% | |
uterus | 5 studies | 50% ± 22% | |
prostate | 5 studies | 23% ± 6% | |
breast | 5 studies | 38% ± 10% | |
pancreas | 4 studies | 37% ± 15% | |
placenta | 4 studies | 41% ± 27% | |
adipose | 4 studies | 25% ± 7% | |
liver | 3 studies | 35% ± 17% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
intestine | 87% | 111156.46 | 838 / 966 | 98% | 61.82 | 519 / 527 |
uterus | 96% | 77008.60 | 164 / 170 | 79% | 56.43 | 362 / 459 |
prostate | 76% | 49150.73 | 185 / 245 | 100% | 96.01 | 500 / 502 |
breast | 72% | 21543.86 | 329 / 459 | 98% | 69.66 | 1097 / 1118 |
bladder | 86% | 90921.00 | 18 / 21 | 82% | 44.35 | 411 / 504 |
esophagus | 69% | 132979.22 | 999 / 1445 | 87% | 31.79 | 160 / 183 |
stomach | 46% | 52340.50 | 165 / 359 | 98% | 60.13 | 281 / 286 |
ovary | 47% | 14631.69 | 84 / 180 | 83% | 22.28 | 358 / 430 |
pancreas | 29% | 11043.30 | 96 / 328 | 96% | 87.89 | 171 / 178 |
lung | 33% | 7990.76 | 191 / 578 | 92% | 37.59 | 1060 / 1155 |
kidney | 20% | 5603.13 | 18 / 89 | 94% | 77.41 | 845 / 901 |
ureter | 0% | 0 | 0 / 0 | 100% | 15.09 | 1 / 1 |
blood vessel | 99% | 92291.32 | 1323 / 1335 | 0% | 0 | 0 / 0 |
heart | 98% | 317038.98 | 847 / 861 | 0% | 0 | 0 / 0 |
muscle | 96% | 127398.12 | 773 / 803 | 0% | 0 | 0 / 0 |
thymus | 7% | 1913.92 | 48 / 653 | 82% | 20.78 | 497 / 605 |
brain | 0% | 31.46 | 3 / 2642 | 79% | 15.59 | 554 / 705 |
adrenal gland | 1% | 153.26 | 2 / 258 | 72% | 22.37 | 165 / 230 |
liver | 0% | 122.40 | 1 / 226 | 69% | 22.42 | 281 / 406 |
skin | 25% | 7283.51 | 460 / 1809 | 43% | 9.72 | 204 / 472 |
adipose | 60% | 17630.30 | 725 / 1204 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 42% | 13.29 | 19 / 45 |
lymph node | 0% | 0 | 0 / 0 | 21% | 3.19 | 6 / 29 |
spleen | 7% | 1735.05 | 16 / 241 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 1% | 0.14 | 1 / 80 |
peripheral blood | 0% | 49.85 | 2 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0003065 | Biological process | positive regulation of heart rate by epinephrine |
GO_0034614 | Biological process | cellular response to reactive oxygen species |
GO_0031529 | Biological process | ruffle organization |
GO_0032781 | Biological process | positive regulation of ATP-dependent activity |
GO_1904706 | Biological process | negative regulation of vascular associated smooth muscle cell proliferation |
GO_0006937 | Biological process | regulation of muscle contraction |
GO_0051496 | Biological process | positive regulation of stress fiber assembly |
GO_0007010 | Biological process | cytoskeleton organization |
GO_0045785 | Biological process | positive regulation of cell adhesion |
GO_0060048 | Biological process | cardiac muscle contraction |
GO_0055010 | Biological process | ventricular cardiac muscle tissue morphogenesis |
GO_0042060 | Biological process | wound healing |
GO_0007015 | Biological process | actin filament organization |
GO_0030336 | Biological process | negative regulation of cell migration |
GO_0045214 | Biological process | sarcomere organization |
GO_0008360 | Biological process | regulation of cell shape |
GO_1904753 | Biological process | negative regulation of vascular associated smooth muscle cell migration |
GO_0008016 | Biological process | regulation of heart contraction |
GO_0030049 | Biological process | muscle filament sliding |
GO_0005862 | Cellular component | muscle thin filament tropomyosin |
GO_0032587 | Cellular component | ruffle membrane |
GO_0005856 | Cellular component | cytoskeleton |
GO_0032059 | Cellular component | bleb |
GO_0005884 | Cellular component | actin filament |
GO_0001725 | Cellular component | stress fiber |
GO_0015629 | Cellular component | actin cytoskeleton |
GO_0030017 | Cellular component | sarcomere |
GO_0005829 | Cellular component | cytosol |
GO_0042803 | Molecular function | protein homodimerization activity |
GO_0008307 | Molecular function | structural constituent of muscle |
GO_0005200 | Molecular function | structural constituent of cytoskeleton |
GO_0051015 | Molecular function | actin filament binding |
GO_0042802 | Molecular function | identical protein binding |
GO_0046982 | Molecular function | protein heterodimerization activity |
GO_0008092 | Molecular function | cytoskeletal protein binding |
GO_0005515 | Molecular function | protein binding |
GO_0003779 | Molecular function | actin binding |
Gene name | TPM1 |
Protein name | Tropomyosin 1 (Alpha), isoform CRA_i (cDNA FLJ54760, highly similar to Rattus norvegicus tropomyosin 1, alpha (Tpm1), transcript variant 7, mRNA) Tropomyosin 1 (Alpha) isoform 4 (Tropomyosin 1 (Alpha), isoform CRA_c) Tropomyosin 1 (cDNA FLJ16459 fis, clone BRCAN2002473, moderately similar to Tropomyosin, fibroblast isoform 2) Tropomyosin alpha-1 chain (Alpha-tropomyosin) (Tropomyosin-1) Tropomyosin 1 |
Synonyms | TMSA C15orf13 HEL-S-265 hCG_33495 |
Description | FUNCTION: Binds to actin filaments in muscle and non-muscle cells . Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction . Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. |
Accessions | H0YL42 ENST00000558910.3 A0A994J554 H0YN06 ENST00000560959.5 ENST00000651590.1 ENST00000560615.6 ENST00000357980.9 A0A0S2Z4G6 ENST00000561395.6 ENST00000558347.5 ENST00000705544.1 ENST00000651622.2 ENST00000560970.6 A0A494BZZ2 ENST00000404484.9 A0A087WTJ7 ENST00000403994.9 [P09493-1] ENST00000610733.1 ENST00000288398.10 [P09493-10] H0YKX5 D9YZV7 D9YZV5 H0YKJ4 ENST00000267996.11 [P09493-7] D9YZV4 H0YKP3 H0YLS7 ENST00000559397.6 [P09493-8] ENST00000559281.6 ENST00000317516.12 ENST00000559556.5 [P09493-9] ENST00000561425.5 H7BYY1 A0A494C0V8 Q8TCG4 P09493 B7Z722 ENST00000334895.10 [P09493-5] ENST00000651704.1 B7Z596 A0A0K0K1I0 ENST00000559831.6 ENST00000558544.5 ENST00000651577.1 H0YK48 H0YL80 Q6ZN40 ENST00000561266.6 [P09493-6] F5H7S3 ENST00000358278.7 [P09493-3] |