TNRC6A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0035195Biological processmiRNA-mediated post-transcriptional gene silencing
GO_0007492Biological processendoderm development
GO_0033962Biological processP-body assembly
GO_0009267Biological processcellular response to starvation
GO_0035278Biological processmiRNA-mediated gene silencing by inhibition of translation
GO_0060213Biological processpositive regulation of nuclear-transcribed mRNA poly(A) tail shortening
GO_0000932Cellular componentP-body
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0016442Cellular componentRISC complex
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005794Cellular componentGolgi apparatus
GO_0030674Molecular functionprotein-macromolecule adaptor activity
GO_0005515Molecular functionprotein binding
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene nameTNRC6A
Protein nameTrinucleotide repeat-containing gene 6A protein (CAG repeat protein 26) (EMSY interactor protein) (GW182 autoantigen) (Protein GW1) (Glycine-tryptophan protein of 182 kDa)
Trinucleotide repeat containing adaptor 6A
SynonymsCAGH26
TNRC6
KIAA1460
DescriptionFUNCTION: Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs). Required for miRNA-dependent repression of translation and for siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins. As a scaffolding protein, associates with argonaute proteins bound to partially complementary mRNAs, and can simultaneously recruit CCR4-NOT and PAN deadenylase complexes. .

AccessionsH7C269
ENST00000395799.8 [Q8NDV7-1]
ENST00000568750.1
I3L3S5
I3L218
H3BRT3
ENST00000315183.11 [Q8NDV7-6]
ENST00000491718.5
ENST00000450465.6
H3BTQ1
Q8NDV7
ENST00000569098.1
ENST00000569376.5