TMC8 report

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I. Expression across cell types

Cell ontologyData table

Name	Number of supported studies	Average coverage
natural killer cell	23 studies	25% ± 7%	Explore
T cell	21 studies	26% ± 7%	Explore
CD8-positive, alpha-beta T cell	21 studies	25% ± 8%	Explore
CD4-positive, alpha-beta T cell	20 studies	27% ± 7%	Explore
regulatory T cell	18 studies	27% ± 7%	Explore
B cell	17 studies	22% ± 5%	Explore
CD16-positive, CD56-dim natural killer cell, human	13 studies	30% ± 9%	Explore
memory B cell	12 studies	20% ± 5%	Explore
CD16-negative, CD56-bright natural killer cell, human	11 studies	29% ± 5%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	11 studies	31% ± 7%	Explore
naive B cell	11 studies	23% ± 6%	Explore
CD8-positive, alpha-beta memory T cell	10 studies	25% ± 9%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	10 studies	27% ± 8%	Explore
gamma-delta T cell	10 studies	26% ± 8%	Explore
CD4-positive, alpha-beta memory T cell	9 studies	26% ± 10%	Explore
mature NK T cell	9 studies	25% ± 7%	Explore
mucosal invariant T cell	9 studies	26% ± 5%	Explore
effector memory CD8-positive, alpha-beta T cell	7 studies	28% ± 6%	Explore
T follicular helper cell	7 studies	25% ± 6%	Explore
microglial cell	7 studies	25% ± 5%	Explore
macrophage	6 studies	25% ± 5%	Explore
exhausted T cell	4 studies	26% ± 8%	Explore
mast cell	4 studies	26% ± 11%	Explore
lymphocyte	4 studies	36% ± 9%	Explore
classical monocyte	3 studies	22% ± 1%	Explore
non-classical monocyte	3 studies	27% ± 9%	Explore
immature B cell	3 studies	21% ± 4%	Explore
effector memory CD4-positive, alpha-beta T cell	3 studies	31% ± 7%	Explore
group 3 innate lymphoid cell	3 studies	24% ± 7%	Explore
innate lymphoid cell	3 studies	25% ± 6%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	3 studies	25% ± 4%	Explore

II. Expression across tissues

sc-RNAseq dataData table

Name	Number of supported studies	Average coverage
peripheral blood	10 studies	20% ± 3%	Explore
lymph node	3 studies	22% ± 2%	Explore

Bulk RNAseq dataData table

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
lung	100%	3664.36	578 / 578	97%	17.06	1119 / 1155
thymus	90%	1387.32	590 / 653	90%	28.71	544 / 605
stomach	91%	794.39	325 / 359	86%	9.73	247 / 286
breast	92%	770.42	423 / 459	81%	8.99	910 / 1118
uterus	84%	574.52	143 / 170	88%	11.79	404 / 459
intestine	83%	3162.25	806 / 966	88%	11.35	466 / 527
bladder	90%	1227.14	19 / 21	81%	9.48	408 / 504
esophagus	79%	603.53	1147 / 1445	92%	11.80	168 / 183
kidney	76%	1004.01	68 / 89	80%	9.02	723 / 901
prostate	91%	1057.52	224 / 245	51%	3.45	258 / 502
skin	58%	387.65	1052 / 1809	83%	15.49	393 / 472
liver	87%	688.87	196 / 226	46%	4.41	186 / 406
brain	41%	273.52	1090 / 2642	76%	6.11	534 / 705
pancreas	20%	105.96	66 / 328	93%	14.45	166 / 178
ovary	25%	150.14	45 / 180	77%	5.89	331 / 430
lymph node	0%	0	0 / 0	100%	97.29	29 / 29
peripheral blood	100%	11012.13	929 / 929	0%	0	0 / 0
spleen	100%	22888.53	241 / 241	0%	0	0 / 0
adrenal gland	78%	522.36	201 / 258	22%	1.10	50 / 230
adipose	98%	1279.89	1179 / 1204	0%	0	0 / 0
tonsil	0%	0	0 / 0	98%	29.57	44 / 45
eye	0%	0	0 / 0	69%	5.68	55 / 80
blood vessel	48%	492.95	647 / 1335	0%	0	0 / 0
heart	38%	211.62	324 / 861	0%	0	0 / 0
muscle	2%	9.61	17 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1