SYNRG | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	26 studies	25% ± 7%	Explore
CD8-positive, alpha-beta T cell	23 studies	26% ± 7%	Explore
CD4-positive, alpha-beta T cell	20 studies	24% ± 7%	Explore
B cell	18 studies	22% ± 7%	Explore
T cell	18 studies	26% ± 9%	Explore
CD16-negative, CD56-bright natural killer cell, human	14 studies	31% ± 12%	Explore
memory B cell	13 studies	18% ± 3%	Explore
CD16-positive, CD56-dim natural killer cell, human	13 studies	23% ± 6%	Explore
gamma-delta T cell	13 studies	27% ± 8%	Explore
mucosal invariant T cell	13 studies	26% ± 7%	Explore
regulatory T cell	13 studies	24% ± 5%	Explore
mature NK T cell	12 studies	26% ± 9%	Explore
CD8-positive, alpha-beta memory T cell	11 studies	27% ± 8%	Explore
endothelial cell	11 studies	27% ± 11%	Explore
naive B cell	10 studies	20% ± 4%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	9 studies	22% ± 5%	Explore
effector memory CD8-positive, alpha-beta T cell	9 studies	29% ± 8%	Explore
adipocyte	9 studies	23% ± 6%	Explore
CD4-positive, alpha-beta memory T cell	8 studies	23% ± 6%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	8 studies	22% ± 6%	Explore
macrophage	8 studies	30% ± 7%	Explore
plasmacytoid dendritic cell	7 studies	23% ± 9%	Explore
microglial cell	6 studies	28% ± 11%	Explore
fibroblast	6 studies	22% ± 6%	Explore
innate lymphoid cell	6 studies	25% ± 6%	Explore
astrocyte	6 studies	29% ± 14%	Explore
interneuron	5 studies	36% ± 21%	Explore
myeloid cell	5 studies	23% ± 5%	Explore
epithelial cell	5 studies	31% ± 12%	Explore
mast cell	5 studies	25% ± 6%	Explore
endothelial cell of lymphatic vessel	5 studies	24% ± 2%	Explore
dendritic cell	5 studies	23% ± 6%	Explore
oligodendrocyte	5 studies	31% ± 9%	Explore
plasma cell	4 studies	30% ± 10%	Explore
leukocyte	4 studies	28% ± 10%	Explore
neuron	4 studies	32% ± 17%	Explore
oligodendrocyte precursor cell	4 studies	28% ± 15%	Explore
immature B cell	4 studies	20% ± 2%	Explore
lymphocyte	4 studies	47% ± 12%	Explore
monocyte	4 studies	23% ± 5%	Explore
pericyte	4 studies	20% ± 4%	Explore
T follicular helper cell	4 studies	24% ± 4%	Explore
effector memory CD4-positive, alpha-beta T cell	4 studies	25% ± 3%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	23% ± 7%	Explore
conventional dendritic cell	3 studies	21% ± 4%	Explore
glutamatergic neuron	3 studies	33% ± 14%	Explore
precursor B cell	3 studies	22% ± 3%	Explore
cardiac muscle cell	3 studies	18% ± 1%	Explore
ciliated cell	3 studies	25% ± 6%	Explore
CD4-positive helper T cell	3 studies	25% ± 6%	Explore
basal cell	3 studies	27% ± 9%	Explore
alveolar macrophage	3 studies	24% ± 7%	Explore
group 3 innate lymphoid cell	3 studies	32% ± 9%	Explore
goblet cell	3 studies	31% ± 14%	Explore
brush cell	3 studies	21% ± 4%	Explore
smooth muscle cell	3 studies	18% ± 0%	Explore
T-helper 17 cell	3 studies	21% ± 2%	Explore
abnormal cell	3 studies	25% ± 8%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	6 studies	21% ± 4%	Explore
brain	6 studies	30% ± 14%	Explore
lung	4 studies	21% ± 4%	Explore
adipose	4 studies	23% ± 2%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	100%	2156.77	2641 / 2642	100%	16.93	705 / 705
lung	100%	3156.66	578 / 578	100%	13.57	1151 / 1155
bladder	100%	2933.29	21 / 21	100%	11.66	502 / 504
prostate	100%	2917.53	245 / 245	100%	16.07	500 / 502
breast	100%	2976.53	459 / 459	100%	14.70	1113 / 1118
esophagus	100%	2458.08	1445 / 1445	99%	13.15	182 / 183
pancreas	100%	1805.89	328 / 328	99%	11.83	177 / 178
thymus	100%	3371.46	653 / 653	99%	15.35	601 / 605
kidney	100%	2693.21	89 / 89	99%	13.77	890 / 901
uterus	100%	3004.56	170 / 170	99%	10.40	453 / 459
stomach	100%	2350.89	359 / 359	99%	10.84	282 / 286
skin	100%	2878.60	1809 / 1809	98%	14.11	463 / 472
intestine	100%	3085.65	966 / 966	98%	9.64	514 / 527
adrenal gland	100%	2975.02	258 / 258	95%	12.33	219 / 230
ovary	100%	2912.76	180 / 180	89%	6.46	384 / 430
liver	100%	1557.15	226 / 226	87%	6.34	353 / 406
adipose	100%	2881.65	1204 / 1204	0%	0	0 / 0
blood vessel	100%	2287.16	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	19.31	29 / 29
spleen	100%	5679.07	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	11.35	45 / 45
muscle	100%	1509.06	802 / 803	0%	0	0 / 0
peripheral blood	98%	2924.83	908 / 929	0%	0	0 / 0
heart	97%	1292.95	837 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	93%	8.67	74 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0006886	Biological process	intracellular protein transport
GO_0006897	Biological process	endocytosis
GO_0030121	Cellular component	AP-1 adaptor complex
GO_0030130	Cellular component	clathrin coat of trans-Golgi network vesicle
GO_0005794	Cellular component	Golgi apparatus
GO_0048471	Cellular component	perinuclear region of cytoplasm
GO_0005737	Cellular component	cytoplasm
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	SYNRG
Protein name	Synergin gamma Synergin gamma (AP1 subunit gamma-binding protein 1) (Gamma-synergin)
Synonyms	SYNG AP1GBP1
Description	FUNCTION: Plays a role in endocytosis and/or membrane trafficking at the trans-Golgi network (TGN) . May act by linking the adapter protein complex AP-1 to other proteins (Probable). Component of clathrin-coated vesicles . Component of the aftiphilin/p200/gamma-synergin complex, which plays roles in AP1G1/AP-1-mediated protein trafficking including the trafficking of transferrin from early to recycling endosomes, and the membrane trafficking of furin and the lysosomal enzyme cathepsin D between the trans-Golgi network (TGN) and endosomes . .
Accessions	A0A087WZF6 ENST00000610513.2 [Q9UMZ2-6] ENST00000632841.1 [Q9UMZ2-9] A0A087WZS7 ENST00000622045.4 [Q9UMZ2-7] ENST00000616179.4 [Q9UMZ2-9] A0A087WW94 ENST00000614941.4 [Q9UMZ2-6] Q9UMZ2 ENST00000618176.4 [Q9UMZ2-4] ENST00000612223.5 [Q9UMZ2-1] ENST00000613407.4 [Q9UMZ2-7] ENST00000621136.4 [Q9UMZ2-4] ENST00000633429.1 [Q9UMZ2-8] ENST00000620424.1 ENST00000633203.1 ENST00000632310.1 ENST00000619541.4 [Q9UMZ2-8] ENST00000614196.1 ENST00000618402.4 [Q9UMZ2-1] ENST00000612770.1

SYNRG report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review