SUN2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007052Biological processmitotic spindle organization
GO_0051642Biological processcentrosome localization
GO_0031022Biological processnuclear migration along microfilament
GO_0090292Biological processnuclear matrix anchoring at nuclear membrane
GO_0051321Biological processmeiotic cell cycle
GO_0030335Biological processpositive regulation of cell migration
GO_0007097Biological processnuclear migration
GO_0021817Biological processnucleokinesis involved in cell motility in cerebral cortex radial glia guided migration
GO_0005637Cellular componentnuclear inner membrane
GO_0005635Cellular componentnuclear envelope
GO_0034993Cellular componentmeiotic nuclear membrane microtubule tethering complex
GO_0010008Cellular componentendosome membrane
GO_0000794Cellular componentcondensed nuclear chromosome
GO_0000781Cellular componentchromosome, telomeric region
GO_0031965Cellular componentnuclear membrane
GO_0043495Molecular functionprotein-membrane adaptor activity
GO_0042802Molecular functionidentical protein binding
GO_0005521Molecular functionlamin binding
GO_0008017Molecular functionmicrotubule binding
GO_0005515Molecular functionprotein binding
GO_0140444Molecular functioncytoskeleton-nuclear membrane anchor activity

IV. Literature review

[source]
Gene nameSUN2
Protein nameSad1 and UNC84 domain containing 2
SUN domain-containing protein 2 (Protein unc-84 homolog B) (Rab5-interacting protein) (Rab5IP) (Sad1/unc-84 protein-like 2)
SynonymsKIAA0668
UNC84B
RAB5IP
FRIGG
DescriptionFUNCTION: As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration. Required for nuclear migration in retinal photoreceptor progenitors implicating association with cytoplasmic dynein-dynactin and kinesin motor complexes, and probably B-type lamins; SUN1 and SUN2 seem to act redundantly. The SUN1/2:KASH5 LINC complex couples telomeres to microtubules during meiosis; SUN1 and SUN2 seem to act at least partial redundantly. Anchors chromosome movement in the prophase of meiosis and is involved in selective gene expression of coding and non-coding RNAs needed for gametogenesis. Required for telomere attachment to nuclear envelope and gametogenesis. May also function on endocytic vesicles as a receptor for RAB5-GDP and participate in the activation of RAB5. .

AccessionsQ9UH99
ENST00000455125.2
B0QY66
ENST00000405018.5 [Q9UH99-2]
ENST00000405510.5 [Q9UH99-1]
ENST00000417332.5
ENST00000456894.6
B0QY67
ENST00000406622.5 [Q9UH99-1]
B0QY68
ENST00000433561.5
ENST00000690927.1
B0QY64
ENST00000439339.1
ENST00000452294.5
A0A8I5QKM0
ENST00000689035.1 [Q9UH99-1]
ENST00000438058.5
B0QY69
B0QY60
B0QY63