STAT4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0019221Biological processcytokine-mediated signaling pathway
GO_0045063Biological processT-helper 1 cell differentiation
GO_0043434Biological processresponse to peptide hormone
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0070741Biological processresponse to interleukin-6
GO_0035722Biological processinterleukin-12-mediated signaling pathway
GO_0007259Biological processcell surface receptor signaling pathway via JAK-STAT
GO_0042127Biological processregulation of cell population proliferation
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0006952Biological processdefense response
GO_0005654Cellular componentnucleoplasm
GO_0090575Cellular componentRNA polymerase II transcription regulator complex
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0042802Molecular functionidentical protein binding
GO_0003700Molecular functionDNA-binding transcription factor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSTAT4
Protein nameSignal transducer and activator of transcription 4 variant 3
Signal transducer and activator of transcription 4
STAT4
Signal transducer and activator of transcription
Synonyms
DescriptionFUNCTION: Transcriptional regulator mainly expressed in hematopoietic cells that plays a critical role in cellular growth, differentiation and immune response . Plays a key role in the differentiation of T-helper 1 cells and the production of interferon-gamma . Participates also in multiple neutrophil functions including chemotaxis and production of the neutrophil extracellular traps (By similarity). After IL12 binding to its receptor IL12RB2, STAT4 interacts with the intracellular domain of IL12RB2 and becomes tyrosine phosphorylated . Phosphorylated STAT4 then homodimerizes and migrates to the nucleus where it can recognize STAT target sequences present in IL12 responsive genes. Although IL12 appears to be the predominant activating signal, STAT4 can also be phosphorylated and activated in response to IFN-gamma stimulation via JAK1 and TYK2 and in response to different interleukins including IL23, IL2 and IL35 . Transcription activation of IFN-gamma gene is mediated by interaction with JUN that forms a complex that efficiently interacts with the AP-1-related sequence of the IFN-gamma promoter (By similarity). In response to IFN-alpha/beta signaling, acts as a transcriptional repressor and suppresses IL5 and IL13 mRNA expression during response to T-cell receptor (TCR) activation . .

AccessionsC9JFG0
ENST00000392320.7
A0A510GAL5
A0A291B130
ENST00000413064.5
C9JM11
E9PG69
E9PBE2
ENST00000432798.1
ENST00000409995.5
ENST00000450994.1
ENST00000358470.8
Q53S87
Q53RU2
Q14765
B7SIX5
A0A2R8Y693
ENST00000647167.1