SRRT | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
CD8-positive, alpha-beta T cell	15 studies	23% ± 5%	Explore
T cell	10 studies	21% ± 7%	Explore
natural killer cell	10 studies	23% ± 5%	Explore
CD8-positive, alpha-beta memory T cell	10 studies	24% ± 4%	Explore
gamma-delta T cell	9 studies	25% ± 10%	Explore
mucosal invariant T cell	8 studies	19% ± 3%	Explore
CD16-positive, CD56-dim natural killer cell, human	7 studies	18% ± 2%	Explore
effector memory CD8-positive, alpha-beta T cell	7 studies	22% ± 4%	Explore
epithelial cell	6 studies	32% ± 17%	Explore
CD16-negative, CD56-bright natural killer cell, human	6 studies	18% ± 1%	Explore
effector CD8-positive, alpha-beta T cell	6 studies	22% ± 4%	Explore
CD4-positive, alpha-beta memory T cell	5 studies	18% ± 2%	Explore
CD4-positive, alpha-beta T cell	5 studies	22% ± 5%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	5 studies	17% ± 2%	Explore
B cell	5 studies	17% ± 4%	Explore
naive B cell	5 studies	18% ± 2%	Explore
plasmacytoid dendritic cell	5 studies	20% ± 4%	Explore
plasmablast	4 studies	36% ± 14%	Explore
exhausted T cell	4 studies	26% ± 9%	Explore
hematopoietic precursor cell	4 studies	21% ± 5%	Explore
fibroblast	4 studies	16% ± 1%	Explore
basal cell	4 studies	25% ± 5%	Explore
mature NK T cell	4 studies	17% ± 2%	Explore
glutamatergic neuron	4 studies	26% ± 6%	Explore
dendritic cell	4 studies	30% ± 9%	Explore
abnormal cell	4 studies	22% ± 6%	Explore
regulatory T cell	4 studies	20% ± 5%	Explore
memory B cell	4 studies	19% ± 3%	Explore
non-classical monocyte	3 studies	21% ± 4%	Explore
endothelial cell	3 studies	27% ± 7%	Explore
precursor B cell	3 studies	22% ± 2%	Explore
pro-B cell	3 studies	25% ± 3%	Explore
ciliated cell	3 studies	21% ± 4%	Explore
effector memory CD4-positive, alpha-beta T cell	3 studies	18% ± 1%	Explore
astrocyte	3 studies	22% ± 4%	Explore
transit amplifying cell	3 studies	25% ± 3%	Explore
erythroblast	3 studies	27% ± 11%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	3 studies	19% ± 4%	Explore
double negative thymocyte	3 studies	32% ± 7%	Explore
oligodendrocyte precursor cell	3 studies	22% ± 7%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	6 studies	19% ± 4%	Explore
brain	6 studies	21% ± 5%	Explore
bone marrow	3 studies	17% ± 2%	Explore
liver	3 studies	25% ± 9%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	7488.85	1445 / 1445	100%	71.88	183 / 183
ovary	100%	10308.59	180 / 180	100%	74.28	430 / 430
pancreas	100%	4957.72	328 / 328	100%	69.89	178 / 178
skin	100%	8761.30	1809 / 1809	100%	95.56	472 / 472
stomach	100%	6345.82	359 / 359	100%	75.97	286 / 286
uterus	100%	10648.83	170 / 170	100%	113.16	459 / 459
liver	100%	5466.90	226 / 226	100%	48.03	405 / 406
thymus	100%	10598.53	653 / 653	100%	78.46	603 / 605
intestine	100%	8235.20	966 / 966	100%	87.83	525 / 527
bladder	100%	7503.62	21 / 21	100%	93.24	502 / 504
prostate	100%	11475.27	245 / 245	100%	91.09	500 / 502
lung	100%	7704.77	578 / 578	99%	76.58	1149 / 1155
breast	100%	8333.82	459 / 459	99%	84.78	1111 / 1118
adrenal gland	100%	8630.54	258 / 258	99%	55.95	228 / 230
brain	99%	5351.44	2618 / 2642	100%	89.15	705 / 705
kidney	100%	7318.97	89 / 89	99%	52.28	888 / 901
adipose	100%	7170.82	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	66.53	80 / 80
lymph node	0%	0	0 / 0	100%	139.41	29 / 29
spleen	100%	11033.78	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	103.67	45 / 45
ureter	0%	0	0 / 0	100%	53.60	1 / 1
blood vessel	100%	6504.53	1334 / 1335	0%	0	0 / 0
muscle	100%	4314.67	799 / 803	0%	0	0 / 0
heart	99%	4139.49	851 / 861	0%	0	0 / 0
peripheral blood	95%	5577.18	884 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0050769	Biological process	positive regulation of neurogenesis
GO_0097150	Biological process	neuronal stem cell population maintenance
GO_0006397	Biological process	mRNA processing
GO_0046685	Biological process	response to arsenic-containing substance
GO_0006355	Biological process	regulation of DNA-templated transcription
GO_0031053	Biological process	primary miRNA processing
GO_0032991	Cellular component	protein-containing complex
GO_0005654	Cellular component	nucleoplasm
GO_1990904	Cellular component	ribonucleoprotein complex
GO_0016604	Cellular component	nuclear body
GO_0005737	Cellular component	cytoplasm
GO_0140262	Molecular function	mRNA cap binding complex binding
GO_0003677	Molecular function	DNA binding
GO_0030674	Molecular function	protein-macromolecule adaptor activity
GO_0005515	Molecular function	protein binding
GO_0003723	Molecular function	RNA binding

IV. Literature review

[source]

Gene name	SRRT
Protein name	Serrate, RNA effector molecule Arsenite-resistance protein 2 Serrate RNA effector molecule homolog (Arsenite-resistance protein 2)
Synonyms	ARS2 ASR2
Description	FUNCTION: Acts as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing machinery during cell proliferation. Contributes to the stability and delivery of capped primary miRNA transcripts to the primary miRNA processing complex containing DGCR8 and DROSHA, thereby playing a role in RNA-mediated gene silencing (RNAi) by miRNAs. Binds capped RNAs (m7GpppG-capped RNA); however interaction is probably mediated via its interaction with NCBP1/CBP80 component of the CBC complex. Involved in cell cycle progression at S phase. Does not directly confer arsenite resistance but rather modulates arsenic sensitivity. Independently of its activity on miRNAs, necessary and sufficient to promote neural stem cell self-renewal. Does so by directly binding SOX2 promoter and positively regulating its transcription (By similarity). .
Accessions	ENST00000614370.4 ENST00000445337.1 ENST00000448764.5 ENST00000449389.1 ENST00000641476.1 H7C3A1 H7C1K0 ENST00000423692.5 ENST00000614484.4 [Q9BXP5-3] A0A286YEP7 ENST00000618411.4 [Q9BXP5-4] A0A0A0MSP6 ENST00000611405.5 [Q9BXP5-1] ENST00000618262.4 [Q9BXP5-2] H7C0U8 A0A087X0F4 C9JUL9 ENST00000431645.1 Q9BXP5

SRRT report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review