Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 11 studies | 26% ± 10% | |
CD8-positive, alpha-beta T cell | 10 studies | 20% ± 5% | |
regulatory T cell | 10 studies | 19% ± 5% | |
glutamatergic neuron | 9 studies | 46% ± 23% | |
epithelial cell | 9 studies | 34% ± 13% | |
GABAergic neuron | 7 studies | 38% ± 19% | |
basal cell | 7 studies | 28% ± 15% | |
natural killer cell | 6 studies | 22% ± 6% | |
CD4-positive, alpha-beta T cell | 6 studies | 23% ± 7% | |
neuron | 6 studies | 33% ± 12% | |
interneuron | 6 studies | 36% ± 19% | |
retinal rod cell | 6 studies | 27% ± 5% | |
hematopoietic precursor cell | 5 studies | 29% ± 18% | |
oligodendrocyte precursor cell | 5 studies | 24% ± 8% | |
astrocyte | 5 studies | 27% ± 6% | |
ciliated cell | 4 studies | 29% ± 16% | |
effector CD8-positive, alpha-beta T cell | 4 studies | 23% ± 7% | |
fibroblast | 4 studies | 17% ± 1% | |
goblet cell | 4 studies | 26% ± 13% | |
T cell | 4 studies | 17% ± 2% | |
transit amplifying cell | 4 studies | 32% ± 16% | |
oligodendrocyte | 4 studies | 24% ± 6% | |
plasmablast | 3 studies | 46% ± 13% | |
neutrophil | 3 studies | 28% ± 6% | |
secretory cell | 3 studies | 34% ± 16% | |
CD16-negative, CD56-bright natural killer cell, human | 3 studies | 16% ± 0% | |
plasma cell | 3 studies | 30% ± 12% | |
lymphocyte | 3 studies | 22% ± 4% | |
memory B cell | 3 studies | 18% ± 3% | |
hepatocyte | 3 studies | 45% ± 23% | |
megakaryocyte-erythroid progenitor cell | 3 studies | 32% ± 17% | |
enteroendocrine cell | 3 studies | 17% ± 0% | |
intestinal crypt stem cell | 3 studies | 30% ± 4% | |
club cell | 3 studies | 19% ± 2% | |
macrophage | 3 studies | 16% ± 1% | |
CD4-positive, alpha-beta memory T cell | 3 studies | 18% ± 1% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
intestine | 100% | 2628.53 | 966 / 966 | 100% | 39.39 | 527 / 527 |
esophagus | 100% | 2532.96 | 1444 / 1445 | 100% | 32.84 | 183 / 183 |
breast | 100% | 1680.41 | 459 / 459 | 100% | 22.12 | 1116 / 1118 |
bladder | 100% | 2315.81 | 21 / 21 | 100% | 27.93 | 503 / 504 |
ovary | 100% | 1486.10 | 180 / 180 | 100% | 16.72 | 429 / 430 |
lung | 99% | 2486.40 | 575 / 578 | 100% | 24.15 | 1155 / 1155 |
uterus | 100% | 2003.18 | 170 / 170 | 99% | 20.50 | 455 / 459 |
stomach | 99% | 1649.95 | 356 / 359 | 99% | 38.04 | 284 / 286 |
pancreas | 100% | 2377.08 | 328 / 328 | 98% | 16.30 | 175 / 178 |
prostate | 100% | 1879.13 | 245 / 245 | 98% | 9.89 | 492 / 502 |
skin | 100% | 4692.36 | 1807 / 1809 | 94% | 15.42 | 445 / 472 |
thymus | 100% | 1505.41 | 651 / 653 | 94% | 7.51 | 567 / 605 |
brain | 92% | 1571.10 | 2442 / 2642 | 96% | 9.43 | 679 / 705 |
liver | 100% | 1584.76 | 225 / 226 | 87% | 9.01 | 355 / 406 |
kidney | 100% | 1877.15 | 89 / 89 | 85% | 7.75 | 769 / 901 |
adrenal gland | 98% | 1121.01 | 253 / 258 | 62% | 4.03 | 143 / 230 |
lymph node | 0% | 0 | 0 / 0 | 100% | 21.80 | 29 / 29 |
spleen | 100% | 3335.41 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 19.89 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 23.33 | 1 / 1 |
peripheral blood | 100% | 9013.05 | 928 / 929 | 0% | 0 | 0 / 0 |
adipose | 100% | 1587.60 | 1199 / 1204 | 0% | 0 | 0 / 0 |
muscle | 99% | 2242.12 | 797 / 803 | 0% | 0 | 0 / 0 |
blood vessel | 99% | 1391.74 | 1321 / 1335 | 0% | 0 | 0 / 0 |
heart | 88% | 973.54 | 756 / 861 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 81% | 7.44 | 65 / 80 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0018105 | Biological process | peptidyl-serine phosphorylation |
GO_0045071 | Biological process | negative regulation of viral genome replication |
GO_0007059 | Biological process | chromosome segregation |
GO_0045087 | Biological process | innate immune response |
GO_0050684 | Biological process | regulation of mRNA processing |
GO_0045070 | Biological process | positive regulation of viral genome replication |
GO_0035556 | Biological process | intracellular signal transduction |
GO_0008380 | Biological process | RNA splicing |
GO_0048024 | Biological process | regulation of mRNA splicing, via spliceosome |
GO_0035092 | Biological process | sperm DNA condensation |
GO_0006468 | Biological process | protein phosphorylation |
GO_0000245 | Biological process | spliceosomal complex assembly |
GO_0005886 | Cellular component | plasma membrane |
GO_0016607 | Cellular component | nuclear speck |
GO_0005654 | Cellular component | nucleoplasm |
GO_0016363 | Cellular component | nuclear matrix |
GO_0005783 | Cellular component | endoplasmic reticulum |
GO_0005829 | Cellular component | cytosol |
GO_0005737 | Cellular component | cytoplasm |
GO_0000785 | Cellular component | chromatin |
GO_0005634 | Cellular component | nucleus |
GO_0106310 | Molecular function | protein serine kinase activity |
GO_0004674 | Molecular function | protein serine/threonine kinase activity |
GO_0000287 | Molecular function | magnesium ion binding |
GO_0004672 | Molecular function | protein kinase activity |
GO_0005524 | Molecular function | ATP binding |
GO_0003723 | Molecular function | RNA binding |
GO_0005515 | Molecular function | protein binding |
Gene name | SRPK1 |
Protein name | non-specific serine/threonine protein kinase (EC 2.7.11.1) SRSF protein kinase 1 (EC 2.7.11.1) (SFRS protein kinase 1) (Serine/arginine-rich protein-specific kinase 1) (SR-protein-specific kinase 1) SRSF protein kinase 1 |
Synonyms | |
Description | FUNCTION: Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Plays a central role in the regulatory network for splicing, controlling the intranuclear distribution of splicing factors in interphase cells and the reorganization of nuclear speckles during mitosis. Can influence additional steps of mRNA maturation, as well as other cellular activities, such as chromatin reorganization in somatic and sperm cells and cell cycle progression. Isoform 2 phosphorylates SFRS2, ZRSR2, LBR and PRM1. Isoform 2 phosphorylates SRSF1 using a directional (C-terminal to N-terminal) and a dual-track mechanism incorporating both processive phosphorylation (in which the kinase stays attached to the substrate after each round of phosphorylation) and distributive phosphorylation steps (in which the kinase and substrate dissociate after each phosphorylation event). The RS domain of SRSF1 binds first to a docking groove in the large lobe of the kinase domain of SRPK1. This induces certain structural changes in SRPK1 and/or RRM2 domain of SRSF1, allowing RRM2 to bind the kinase and initiate phosphorylation. The cycles continue for several phosphorylation steps in a processive manner (steps 1-8) until the last few phosphorylation steps (approximately steps 9-12). During that time, a mechanical stress induces the unfolding of the beta-4 motif in RRM2, which then docks at the docking groove of SRPK1. This also signals RRM2 to begin to dissociate, which facilitates SRSF1 dissociation after phosphorylation is completed. Isoform 2 can mediate hepatitis B virus (HBV) core protein phosphorylation. It plays a negative role in the regulation of HBV replication through a mechanism not involving the phosphorylation of the core protein but by reducing the packaging efficiency of the pregenomic RNA (pgRNA) without affecting the formation of the viral core particles. Isoform 1 and isoform 2 can induce splicing of exon 10 in MAPT/TAU. The ratio of isoform 1/isoform 2 plays a decisive role in determining cell fate in K-562 leukaemic cell line: isoform 2 favors proliferation where as isoform 1 favors differentiation. . |
Accessions | D6RBF8 ENST00000423325.6 [Q96SB4-4] H3BLV9 ENST00000361690.7 D6RB98 ENST00000507909.1 ENST00000508473.5 H0Y932 Q96SB4 ENST00000512445.5 ENST00000373825.7 [Q96SB4-2] D6RDZ3 ENST00000510290.5 D6RBM8 ENST00000507292.1 |