SPG7 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	25 studies	26% ± 10%	Explore
fibroblast	14 studies	21% ± 5%	Explore
oligodendrocyte precursor cell	12 studies	33% ± 14%	Explore
ciliated cell	11 studies	25% ± 8%	Explore
natural killer cell	10 studies	18% ± 4%	Explore
T cell	9 studies	19% ± 3%	Explore
B cell	9 studies	22% ± 9%	Explore
glutamatergic neuron	9 studies	38% ± 23%	Explore
macrophage	9 studies	27% ± 12%	Explore
type I pneumocyte	9 studies	23% ± 7%	Explore
adipocyte	9 studies	23% ± 4%	Explore
astrocyte	9 studies	25% ± 9%	Explore
oligodendrocyte	9 studies	25% ± 8%	Explore
CD8-positive, alpha-beta T cell	8 studies	19% ± 4%	Explore
epithelial cell	8 studies	36% ± 17%	Explore
endothelial cell of lymphatic vessel	8 studies	23% ± 8%	Explore
CD16-negative, CD56-bright natural killer cell, human	7 studies	20% ± 5%	Explore
CD16-positive, CD56-dim natural killer cell, human	7 studies	19% ± 3%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	7 studies	19% ± 5%	Explore
capillary endothelial cell	7 studies	20% ± 2%	Explore
microglial cell	7 studies	27% ± 7%	Explore
regulatory T cell	7 studies	17% ± 2%	Explore
myeloid cell	7 studies	24% ± 8%	Explore
GABAergic neuron	7 studies	37% ± 21%	Explore
CD8-positive, alpha-beta memory T cell	6 studies	18% ± 2%	Explore
basal cell	6 studies	32% ± 12%	Explore
CD4-positive, alpha-beta T cell	6 studies	21% ± 6%	Explore
effector memory CD8-positive, alpha-beta T cell	6 studies	21% ± 7%	Explore
neuron	6 studies	35% ± 15%	Explore
smooth muscle cell	6 studies	18% ± 2%	Explore
gamma-delta T cell	6 studies	19% ± 7%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	5 studies	20% ± 9%	Explore
cardiac muscle cell	5 studies	20% ± 2%	Explore
dendritic cell	5 studies	27% ± 15%	Explore
abnormal cell	5 studies	24% ± 14%	Explore
type II pneumocyte	5 studies	20% ± 6%	Explore
club cell	5 studies	21% ± 6%	Explore
pericyte	5 studies	20% ± 5%	Explore
interneuron	5 studies	36% ± 21%	Explore
plasmacytoid dendritic cell	5 studies	22% ± 5%	Explore
respiratory goblet cell	4 studies	18% ± 3%	Explore
secretory cell	4 studies	30% ± 7%	Explore
non-classical monocyte	4 studies	28% ± 12%	Explore
naive B cell	4 studies	18% ± 1%	Explore
lymphocyte	4 studies	27% ± 8%	Explore
myofibroblast cell	4 studies	24% ± 8%	Explore
goblet cell	4 studies	32% ± 17%	Explore
classical monocyte	3 studies	31% ± 10%	Explore
mature NK T cell	3 studies	19% ± 2%	Explore
glomerular endothelial cell	3 studies	22% ± 5%	Explore
amacrine cell	3 studies	23% ± 3%	Explore
progenitor cell	3 studies	19% ± 4%	Explore
mast cell	3 studies	32% ± 13%	Explore
mononuclear phagocyte	3 studies	21% ± 4%	Explore
vein endothelial cell	3 studies	28% ± 15%	Explore
T follicular helper cell	3 studies	17% ± 0%	Explore
endothelial cell of vascular tree	3 studies	27% ± 12%	Explore
innate lymphoid cell	3 studies	16% ± 1%	Explore
hepatocyte	3 studies	34% ± 17%	Explore
effector memory CD4-positive, alpha-beta T cell	3 studies	22% ± 9%	Explore
alveolar macrophage	3 studies	23% ± 8%	Explore
monocyte	3 studies	24% ± 4%	Explore
transit amplifying cell	3 studies	31% ± 20%	Explore
brush cell	3 studies	18% ± 3%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	14 studies	29% ± 16%	Explore
lung	7 studies	25% ± 8%	Explore
intestine	4 studies	21% ± 6%	Explore
adipose	4 studies	22% ± 4%	Explore
peripheral blood	3 studies	38% ± 6%	Explore
eye	3 studies	28% ± 14%	Explore
heart	3 studies	19% ± 2%	Explore
liver	3 studies	30% ± 15%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	5627.51	1445 / 1445	100%	7.92	183 / 183
intestine	100%	7225.32	966 / 966	100%	7.95	527 / 527
thymus	100%	12582.91	653 / 653	100%	10.70	604 / 605
brain	100%	6080.06	2637 / 2642	100%	11.16	705 / 705
bladder	100%	6519.95	21 / 21	100%	8.91	503 / 504
prostate	100%	7906.01	245 / 245	100%	7.55	501 / 502
uterus	100%	7445.82	170 / 170	100%	8.31	458 / 459
lung	100%	5858.99	578 / 578	100%	7.91	1152 / 1155
skin	100%	6415.24	1809 / 1809	100%	7.52	470 / 472
adrenal gland	100%	8502.70	258 / 258	100%	8.29	229 / 230
kidney	100%	6828.93	89 / 89	100%	9.53	897 / 901
breast	100%	6650.24	459 / 459	100%	6.70	1113 / 1118
liver	100%	5519.77	226 / 226	99%	5.40	402 / 406
pancreas	100%	4003.26	328 / 328	99%	8.72	176 / 178
stomach	100%	5028.51	359 / 359	99%	6.99	282 / 286
ovary	100%	8640.57	180 / 180	96%	4.93	411 / 430
adipose	100%	6279.67	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	7.53	29 / 29
muscle	100%	5466.79	803 / 803	0%	0	0 / 0
spleen	100%	8536.70	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	6.68	45 / 45
ureter	0%	0	0 / 0	100%	18.19	1 / 1
blood vessel	100%	4570.44	1334 / 1335	0%	0	0 / 0
heart	99%	5665.45	855 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	98%	8.15	78 / 80
peripheral blood	94%	3266.64	874 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0034982	Biological process	mitochondrial protein processing
GO_0008089	Biological process	anterograde axonal transport
GO_1902686	Biological process	mitochondrial outer membrane permeabilization involved in programmed cell death
GO_0006508	Biological process	proteolysis
GO_0046902	Biological process	regulation of mitochondrial membrane permeability
GO_0110097	Biological process	regulation of calcium import into the mitochondrion
GO_0007399	Biological process	nervous system development
GO_0005739	Cellular component	mitochondrion
GO_0005745	Cellular component	m-AAA complex
GO_0005743	Cellular component	mitochondrial inner membrane
GO_0005757	Cellular component	mitochondrial permeability transition pore complex
GO_1904115	Cellular component	axon cytoplasm
GO_0008233	Molecular function	peptidase activity
GO_0004176	Molecular function	ATP-dependent peptidase activity
GO_0051082	Molecular function	unfolded protein binding
GO_0008270	Molecular function	zinc ion binding
GO_0005524	Molecular function	ATP binding
GO_0004222	Molecular function	metalloendopeptidase activity
GO_0005515	Molecular function	protein binding
GO_0016887	Molecular function	ATP hydrolysis activity

IV. Literature review

[source]

Gene name	SPG7
Protein name	SPG7 matrix AAA peptidase subunit, paraplegin Paraplegin (EC 3.4.24.-) (Cell matrix adhesion regulator) (Spastic paraplegia 7 protein)
Synonyms	PGN CMAR CAR
Description	FUNCTION: ATP-dependent zinc metalloprotease. Plays a role in the formation and regulation of the mitochondrial permeability transition pore (mPTP) and its proteolytic activity is dispensable for this function . .
Accessions	H3BTY6 ENST00000642334.1 ENST00000646445.1 A0A2R8Y7N2 ENST00000646716.1 A0A2R8YG79 A0A2R8Y530 ENST00000643307.1 ENST00000643649.1 ENST00000566371.6 A0A2R8Y4Y7 Q9UQ90 ENST00000646303.1 ENST00000561911.5 ENST00000645897.1 ENST00000646589.1 A0A2R8YDQ1 ENST00000268704.7 ENST00000646399.1 H3BTR8 A0A2R8YGV4 ENST00000644671.1 J3KRF6 ENST00000567138.3 ENST00000646930.1 A0A2R8YFW4 ENST00000643954.1 ENST00000647032.1 ENST00000646531.1 ENST00000643957.1 ENST00000565891.2 A0A2R8Y6E8 A0A2R8Y6K2 A0A2R8YFF4 ENST00000646263.1 [Q9UQ90-2] A0A2R8YG90 ENST00000566221.5 A0A2R8YFN9 A0A2R8Y4Z7 ENST00000644044.1 ENST00000644498.1 A0A2R8YFQ9 A0A2R8Y856 A0A2R8Y4L7 ENST00000645354.1 ENST00000644901.1 H3BNE4 A0A2R8Y3M4 ENST00000341316.6 [Q9UQ90-2] A0A2R8YDW8 ENST00000645533.1 ENST00000645258.1 ENST00000643668.1 A0A2R8Y617 A0A2R8YGZ0 ENST00000564409.2 ENST00000569820.6 A0A2U3TZH1 A0A2R8YCU3 A0A2R8Y4M8 ENST00000645063.1 A0A2R8YEH4 ENST00000647227.1 A0A2R8Y7B8 ENST00000643370.1 ENST00000647079.1 ENST00000645818.2 [Q9UQ90-1] A0A2R8YDS3 ENST00000646826.1 ENST00000643724.1 ENST00000643105.1 ENST00000566682.2 ENST00000643345.1 A0A2R8Y632 A0A087X0F5 ENST00000642371.1 A0A2R8Y726 A0A2R8Y4M0 A0A2R8Y7E2 H3BMP1 A0A2R8Y729 ENST00000645886.1 A0A2R8YDM8 A0A2R8Y6Z7 A0A2R8YDU1 ENST00000645042.1 A0A2R8Y4L0 ENST00000644781.1 A0A2R8YFJ7 ENST00000644751.1 ENST00000644210.1

SPG7 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review