SLBP | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
B cell	20 studies	24% ± 9%	Explore
T cell	18 studies	25% ± 9%	Explore
CD8-positive, alpha-beta T cell	16 studies	30% ± 12%	Explore
CD4-positive, alpha-beta T cell	15 studies	26% ± 11%	Explore
regulatory T cell	15 studies	24% ± 7%	Explore
natural killer cell	14 studies	28% ± 14%	Explore
memory B cell	11 studies	23% ± 7%	Explore
gamma-delta T cell	10 studies	25% ± 10%	Explore
CD16-negative, CD56-bright natural killer cell, human	9 studies	20% ± 2%	Explore
fibroblast	9 studies	20% ± 6%	Explore
CD8-positive, alpha-beta memory T cell	9 studies	23% ± 5%	Explore
naive B cell	8 studies	20% ± 4%	Explore
CD4-positive, alpha-beta memory T cell	7 studies	22% ± 6%	Explore
CD16-positive, CD56-dim natural killer cell, human	7 studies	20% ± 5%	Explore
effector memory CD8-positive, alpha-beta T cell	7 studies	22% ± 6%	Explore
endothelial cell	7 studies	22% ± 7%	Explore
epithelial cell	7 studies	30% ± 16%	Explore
effector CD8-positive, alpha-beta T cell	6 studies	25% ± 7%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	6 studies	20% ± 6%	Explore
mature NK T cell	6 studies	19% ± 4%	Explore
plasmacytoid dendritic cell	6 studies	22% ± 6%	Explore
plasmablast	5 studies	42% ± 14%	Explore
mucosal invariant T cell	5 studies	19% ± 2%	Explore
pro-B cell	5 studies	32% ± 11%	Explore
precursor B cell	5 studies	31% ± 12%	Explore
effector memory CD4-positive, alpha-beta T cell	5 studies	23% ± 4%	Explore
basal cell	5 studies	28% ± 12%	Explore
classical monocyte	4 studies	27% ± 7%	Explore
conventional dendritic cell	4 studies	42% ± 14%	Explore
non-classical monocyte	4 studies	32% ± 8%	Explore
erythroblast	4 studies	53% ± 25%	Explore
pericyte	4 studies	20% ± 4%	Explore
innate lymphoid cell	4 studies	18% ± 1%	Explore
germinal center B cell	4 studies	31% ± 11%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	22% ± 3%	Explore
abnormal cell	4 studies	19% ± 3%	Explore
CD4-positive, alpha-beta cytotoxic T cell	4 studies	23% ± 5%	Explore
leukocyte	3 studies	29% ± 8%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	3 studies	18% ± 2%	Explore
hematopoietic precursor cell	3 studies	46% ± 10%	Explore
neuron	3 studies	24% ± 9%	Explore
smooth muscle cell	3 studies	18% ± 2%	Explore
connective tissue cell	3 studies	20% ± 5%	Explore
myeloid cell	3 studies	26% ± 4%	Explore
plasma cell	3 studies	39% ± 3%	Explore
immature B cell	3 studies	18% ± 2%	Explore
ciliated cell	3 studies	32% ± 4%	Explore
T follicular helper cell	3 studies	22% ± 5%	Explore
exhausted T cell	3 studies	23% ± 5%	Explore
type I pneumocyte	3 studies	24% ± 6%	Explore
GABAergic neuron	3 studies	29% ± 7%	Explore
glutamatergic neuron	3 studies	38% ± 9%	Explore
erythrocyte	3 studies	40% ± 14%	Explore
transit amplifying cell	3 studies	27% ± 6%	Explore
hematopoietic stem cell	3 studies	24% ± 10%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	8 studies	24% ± 8%	Explore
lung	8 studies	22% ± 7%	Explore
lymph node	4 studies	17% ± 2%	Explore
bone marrow	3 studies	22% ± 8%	Explore
liver	3 studies	33% ± 25%	Explore
brain	3 studies	26% ± 4%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	2111.47	1445 / 1445	100%	101.66	183 / 183
intestine	100%	2011.30	966 / 966	100%	109.29	527 / 527
lung	100%	2168.44	578 / 578	100%	107.16	1155 / 1155
ovary	100%	1995.73	180 / 180	100%	125.28	430 / 430
stomach	100%	1619.91	359 / 359	100%	106.74	286 / 286
uterus	100%	1980.03	170 / 170	100%	150.40	459 / 459
breast	100%	2125.03	459 / 459	100%	104.18	1117 / 1118
bladder	100%	2216.95	21 / 21	100%	119.50	503 / 504
brain	100%	2107.59	2634 / 2642	100%	78.82	705 / 705
thymus	100%	1855.86	653 / 653	100%	89.36	603 / 605
prostate	100%	1756.41	245 / 245	100%	75.71	500 / 502
skin	100%	3090.44	1809 / 1809	99%	94.44	468 / 472
liver	100%	1123.50	226 / 226	99%	54.88	401 / 406
adrenal gland	100%	1891.51	258 / 258	99%	64.48	227 / 230
kidney	100%	2019.56	89 / 89	98%	57.60	887 / 901
pancreas	99%	989.31	326 / 328	99%	82.19	176 / 178
adipose	100%	2271.09	1204 / 1204	0%	0	0 / 0
blood vessel	100%	2284.99	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	192.19	29 / 29
spleen	100%	2116.48	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	144.63	45 / 45
ureter	0%	0	0 / 0	100%	55.37	1 / 1
muscle	98%	963.96	788 / 803	0%	0	0 / 0
peripheral blood	97%	2552.10	904 / 929	0%	0	0 / 0
heart	95%	837.89	816 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	94%	48.33	75 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0006398	Biological process	mRNA 3'-end processing by stem-loop binding and cleavage
GO_0051028	Biological process	mRNA transport
GO_0002191	Biological process	cap-dependent translational initiation
GO_0062073	Cellular component	histone mRNA stem-loop binding complex
GO_0005730	Cellular component	nucleolus
GO_0071204	Cellular component	histone pre-mRNA 3'end processing complex
GO_0005654	Cellular component	nucleoplasm
GO_0005829	Cellular component	cytosol
GO_1990904	Cellular component	ribonucleoprotein complex
GO_0005737	Cellular component	cytoplasm
GO_0005634	Cellular component	nucleus
GO_0071207	Molecular function	histone pre-mRNA stem-loop binding
GO_0071208	Molecular function	histone pre-mRNA DCP binding
GO_0042802	Molecular function	identical protein binding
GO_0005515	Molecular function	protein binding
GO_0003729	Molecular function	mRNA binding
GO_0003723	Molecular function	RNA binding

IV. Literature review

[source]

Gene name	SLBP
Protein name	Stem-loop (Histone) binding protein (cDNA, FLJ96722, Homo sapiens stem-loop (histone) binding protein (SLBP), mRNA) Stem-loop (Histone) binding protein, isoform CRA_d (cDNA FLJ35995 fis, clone TESTI2014979, highly similar to Histone RNA hairpin-binding protein) Histone RNA hairpin-binding protein (Histone stem-loop-binding protein) Stem-loop binding protein
Synonyms	hCG_19671 HBP
Description	FUNCTION: RNA-binding protein involved in the histone pre-mRNA processing . Binds the stem-loop structure of replication-dependent histone pre-mRNAs and contributes to efficient 3'-end processing by stabilizing the complex between histone pre-mRNA and U7 small nuclear ribonucleoprotein (snRNP), via the histone downstream element (HDE) . Plays an important role in targeting mature histone mRNA from the nucleus to the cytoplasm and to the translation machinery . Stabilizes mature histone mRNA and could be involved in cell-cycle regulation of histone gene expression . Involved in the mechanism by which growing oocytes accumulate histone proteins that support early embryogenesis (By similarity). Binds to the 5' side of the stem-loop structure of histone pre-mRNAs (By similarity). .
Accessions	ENST00000483348.5 H0YAE8 H7C4H8 E7EUV9 Q53XR2 ENST00000489418.6 [Q14493-1] ENST00000318386.8 ENST00000429429.6 [Q14493-2] B3KSC5 ENST00000480936.1 Q14493 ENST00000488267.5 F8W8D3

SLBP report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review