SHKBP1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
classical monocyte	23 studies	32% ± 14%	Explore
non-classical monocyte	19 studies	32% ± 15%	Explore
monocyte	16 studies	24% ± 9%	Explore
B cell	15 studies	23% ± 6%	Explore
natural killer cell	14 studies	23% ± 5%	Explore
CD8-positive, alpha-beta T cell	13 studies	21% ± 5%	Explore
conventional dendritic cell	12 studies	31% ± 17%	Explore
regulatory T cell	12 studies	23% ± 4%	Explore
CD16-positive, CD56-dim natural killer cell, human	10 studies	24% ± 5%	Explore
CD4-positive, alpha-beta T cell	10 studies	20% ± 4%	Explore
gamma-delta T cell	10 studies	23% ± 8%	Explore
memory B cell	9 studies	22% ± 5%	Explore
macrophage	9 studies	21% ± 7%	Explore
CD16-negative, CD56-bright natural killer cell, human	9 studies	22% ± 4%	Explore
naive B cell	9 studies	19% ± 4%	Explore
dendritic cell	7 studies	36% ± 18%	Explore
CD8-positive, alpha-beta memory T cell	6 studies	22% ± 10%	Explore
mature NK T cell	6 studies	21% ± 2%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	6 studies	19% ± 2%	Explore
mucosal invariant T cell	6 studies	19% ± 2%	Explore
T cell	6 studies	23% ± 6%	Explore
plasmacytoid dendritic cell	6 studies	21% ± 6%	Explore
CD4-positive, alpha-beta memory T cell	5 studies	21% ± 2%	Explore
effector memory CD8-positive, alpha-beta T cell	5 studies	23% ± 2%	Explore
precursor B cell	5 studies	26% ± 10%	Explore
hematopoietic precursor cell	4 studies	26% ± 8%	Explore
exhausted T cell	4 studies	24% ± 6%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	4 studies	17% ± 1%	Explore
myeloid cell	4 studies	26% ± 11%	Explore
endothelial cell	4 studies	23% ± 8%	Explore
T follicular helper cell	4 studies	19% ± 1%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	24% ± 5%	Explore
effector CD8-positive, alpha-beta T cell	4 studies	23% ± 6%	Explore
effector memory CD4-positive, alpha-beta T cell	4 studies	24% ± 4%	Explore
plasmablast	3 studies	54% ± 3%	Explore
neutrophil	3 studies	24% ± 6%	Explore
epithelial cell	3 studies	27% ± 1%	Explore
immature B cell	3 studies	23% ± 8%	Explore
germinal center B cell	3 studies	23% ± 3%	Explore
hematopoietic stem cell	3 studies	19% ± 3%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	3 studies	21% ± 6%	Explore
double negative thymocyte	3 studies	26% ± 5%	Explore
abnormal cell	3 studies	20% ± 5%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	13 studies	26% ± 8%	Explore
lung	3 studies	23% ± 3%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	2946.53	1445 / 1445	100%	80.80	183 / 183
ovary	100%	2194.93	180 / 180	100%	95.96	430 / 430
thymus	100%	3529.40	653 / 653	100%	64.81	604 / 605
stomach	100%	2678.23	359 / 359	100%	78.09	285 / 286
intestine	100%	3111.08	966 / 966	100%	74.53	525 / 527
uterus	100%	3236.68	170 / 170	99%	87.17	456 / 459
skin	100%	3063.68	1808 / 1809	99%	73.78	469 / 472
lung	100%	5064.52	578 / 578	99%	75.62	1144 / 1155
kidney	100%	3048.44	89 / 89	99%	47.75	892 / 901
pancreas	99%	1685.99	326 / 328	99%	75.99	177 / 178
prostate	100%	3182.06	245 / 245	99%	36.75	496 / 502
breast	100%	2799.69	459 / 459	99%	52.07	1102 / 1118
bladder	100%	3239.48	21 / 21	98%	85.71	496 / 504
adrenal gland	100%	2675.06	258 / 258	95%	34.34	219 / 230
liver	97%	1253.47	219 / 226	94%	32.49	383 / 406
brain	65%	624.43	1718 / 2642	90%	27.57	633 / 705
adipose	100%	2950.77	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	163.91	29 / 29
peripheral blood	100%	30293.08	929 / 929	0%	0	0 / 0
spleen	100%	10697.56	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	84.76	45 / 45
ureter	0%	0	0 / 0	100%	32.01	1 / 1
blood vessel	100%	3050.45	1332 / 1335	0%	0	0 / 0
heart	98%	1370.62	842 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	98%	39.05	78 / 80
muscle	68%	783.28	545 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0051260	Biological process	protein homooligomerization
GO_0045742	Biological process	positive regulation of epidermal growth factor receptor signaling pathway
GO_0005764	Cellular component	lysosome
GO_0042802	Molecular function	identical protein binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	SHKBP1
Protein name	SH3KBP1-binding protein 1 (SETA-binding protein 1) SH3KBP1 binding protein 1, isoform CRA_b (cDNA FLJ41701 fis, clone HCHON2006250, highly similar to Homo sapiens SH3KBP1 binding protein 1 (SHKBP1), mRNA) SH3KBP1 binding protein 1
Synonyms	hCG_1995509 PP203 SB1
Description	FUNCTION: Inhibits CBL-SH3KBP1 complex mediated down-regulation of EGFR signaling by sequestration of SH3KBP1. Binds to SH3KBP1 and prevents its interaction with CBL and inhibits translocation of SH3KBP1 to EGFR containing vesicles upon EGF stimulation. .
Accessions	M0QYB1 M0QYJ9 M0QZF4 M0QX42 M0R0E3 Q8TBC3 M0R0S2 M0QZF2 M0QXA4 ENST00000595726.1 M0R0K4 M0R204 ENST00000593764.5 M0QZE8 ENST00000595945.5 ENST00000596163.5 ENST00000595631.5 ENST00000597396.5 B3KVX8 ENST00000595523.5 ENST00000595803.5 ENST00000594862.1 M0R2P6 ENST00000291842.10 [Q8TBC3-1] ENST00000600718.5 ENST00000600733.5 M0R0S1 M0R2U6 ENST00000594298.5 ENST00000599575.5 ENST00000600320.5 M0R1G0 ENST00000602011.5

SHKBP1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review