SETD2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0010569Biological processregulation of double-strand break repair via homologous recombination
GO_0010793Biological processregulation of mRNA export from nucleus
GO_0001525Biological processangiogenesis
GO_0010468Biological processregulation of gene expression
GO_1902850Biological processmicrotubule cytoskeleton organization involved in mitosis
GO_0010038Biological processresponse to metal ion
GO_0035441Biological processcell migration involved in vasculogenesis
GO_0060039Biological processpericardium development
GO_0030900Biological processforebrain development
GO_0051607Biological processdefense response to virus
GO_0060669Biological processembryonic placenta morphogenesis
GO_0043279Biological processresponse to alkaloid
GO_0006368Biological processtranscription elongation by RNA polymerase II
GO_0035987Biological processendodermal cell differentiation
GO_0014070Biological processresponse to organic cyclic compound
GO_0048864Biological processstem cell development
GO_0032727Biological processpositive regulation of interferon-alpha production
GO_0048332Biological processmesoderm morphogenesis
GO_0001763Biological processmorphogenesis of a branching structure
GO_0010508Biological processpositive regulation of autophagy
GO_0006355Biological processregulation of DNA-templated transcription
GO_0001843Biological processneural tube closure
GO_0048701Biological processembryonic cranial skeleton morphogenesis
GO_0048863Biological processstem cell differentiation
GO_0006298Biological processmismatch repair
GO_0034728Biological processnucleosome organization
GO_0045778Biological processpositive regulation of ossification
GO_0018023Biological processpeptidyl-lysine trimethylation
GO_1905634Biological processregulation of protein localization to chromatin
GO_0034340Biological processresponse to type I interferon
GO_0032465Biological processregulation of cytokinesis
GO_0060977Biological processcoronary vasculature morphogenesis
GO_0005654Cellular componentnucleoplasm
GO_0005737Cellular componentcytoplasm
GO_0005694Cellular componentchromosome
GO_0005634Cellular componentnucleus
GO_0140955Molecular functionhistone H3K36 trimethyltransferase activity
GO_0043014Molecular functionalpha-tubulin binding
GO_0016279Molecular functionprotein-lysine N-methyltransferase activity
GO_0046872Molecular functionmetal ion binding
GO_0140938Molecular functionhistone H3 methyltransferase activity
GO_0046975Molecular functionhistone H3K36 methyltransferase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSETD2
Protein nameSET domain containing 2, histone lysine methyltransferase
[histone H3]-lysine(36) N-trimethyltransferase (EC 2.1.1.359) (SET domain-containing protein 2)
Histone-lysine N-methyltransferase SETD2 (EC 2.1.1.359) (HIF-1) (Huntingtin yeast partner B) (Huntingtin-interacting protein 1) (HIP-1) (Huntingtin-interacting protein B) (Lysine N-methyltransferase 3A) (Protein-lysine N-methyltransferase SETD2) (EC 2.1.1.-) (SET domain-containing protein 2) (hSET2) (p231HBP)
SynonymsHYPB
KMT3A
KIAA1732
HSPC069
HIF1
SET2
DescriptionFUNCTION: Histone methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using dimethylated 'Lys-36' (H3K36me2) as substrate . It is capable of trimethylating unmethylated H3K36 (H3K36me0) in vitro . Represents the main enzyme generating H3K36me3, a specific tag for epigenetic transcriptional activation (By similarity). Plays a role in chromatin structure modulation during elongation by coordinating recruitment of the FACT complex and by interacting with hyperphosphorylated POLR2A . Acts as a key regulator of DNA mismatch repair in G1 and early S phase by generating H3K36me3, a mark required to recruit MSH6 subunit of the MutS alpha complex: early recruitment of the MutS alpha complex to chromatin to be replicated allows a quick identification of mismatch DNA to initiate the mismatch repair reaction . Required for DNA double-strand break repair in response to DNA damage: acts by mediating formation of H3K36me3, promoting recruitment of RAD51 and DNA repair via homologous recombination (HR) . Acts as a tumor suppressor . H3K36me3 also plays an essential role in the maintenance of a heterochromatic state, by recruiting DNA methyltransferase DNMT3A . H3K36me3 is also enhanced in intron-containing genes, suggesting that SETD2 recruitment is enhanced by splicing and that splicing is coupled to recruitment of elongating RNA polymerase . Required during angiogenesis (By similarity). Required for endoderm development by promoting embryonic stem cell differentiation toward endoderm: acts by mediating formation of H3K36me3 in distal promoter regions of FGFR3, leading to regulate transcription initiation of FGFR3 (By similarity). In addition to histones, also mediates methylation of other proteins, such as tubulins and STAT1 . Trimethylates 'Lys-40' of alpha-tubulins such as TUBA1B (alpha-TubK40me3); alpha-TubK40me3 is required for normal mitosis and cytokinesis and may be a specific tag in cytoskeletal remodeling . Involved in interferon-alpha-induced antiviral defense by mediating both monomethylation of STAT1 at 'Lys-525' and catalyzing H3K36me3 on promoters of some interferon-stimulated genes (ISGs) to activate gene transcription . .; FUNCTION: (Microbial infection) Recruited to the promoters of adenovirus 12 E1A gene in case of infection, possibly leading to regulate its expression. .

AccessionsENST00000690157.1
H7C3H4
ENST00000409792.4 [Q9BYW2-1]
ENST00000685505.1
ENST00000686876.1
H7BZ93
A0A8I5KV15
A0A8I5KSB8
A0A8I5KQS3
ENST00000693321.1
A0A8I5KNR2
ENST00000638947.2
ENST00000445387.5
H7BXT4
ENST00000685399.1
ENST00000692883.1
ENST00000431180.5
A0A8I5KYR1
ENST00000412450.1
ENST00000688290.1
ENST00000691902.1
ENST00000686773.1
ENST00000685005.1
A0A8I5QJW6
Q9BYW2
A0A8I5KPS6
ENST00000330022.11
A0A8I5KWD0
C9JG86
A0A1W2PPX9
A0A8I5KW81
ENST00000690461.1
ENST00000691544.1