RGCC | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	41 studies	42% ± 18%	Explore
CD4-positive, alpha-beta T cell	25 studies	39% ± 15%	Explore
CD8-positive, alpha-beta T cell	24 studies	34% ± 16%	Explore
fibroblast	22 studies	40% ± 18%	Explore
T cell	21 studies	41% ± 16%	Explore
conventional dendritic cell	19 studies	40% ± 13%	Explore
regulatory T cell	19 studies	39% ± 14%	Explore
capillary endothelial cell	18 studies	58% ± 19%	Explore
macrophage	16 studies	41% ± 19%	Explore
ciliated cell	16 studies	38% ± 13%	Explore
classical monocyte	15 studies	27% ± 13%	Explore
natural killer cell	13 studies	31% ± 11%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	13 studies	36% ± 15%	Explore
oligodendrocyte	13 studies	38% ± 14%	Explore
pericyte	12 studies	41% ± 23%	Explore
astrocyte	12 studies	28% ± 12%	Explore
dendritic cell	11 studies	35% ± 14%	Explore
endothelial cell of artery	11 studies	28% ± 10%	Explore
endothelial cell of vascular tree	11 studies	34% ± 13%	Explore
B cell	10 studies	22% ± 5%	Explore
smooth muscle cell	10 studies	28% ± 10%	Explore
type I pneumocyte	10 studies	46% ± 23%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	10 studies	32% ± 16%	Explore
gamma-delta T cell	10 studies	36% ± 10%	Explore
monocyte	9 studies	25% ± 9%	Explore
mature NK T cell	9 studies	32% ± 13%	Explore
basal cell	9 studies	41% ± 14%	Explore
alveolar macrophage	8 studies	55% ± 28%	Explore
plasma cell	8 studies	33% ± 9%	Explore
myeloid cell	8 studies	39% ± 7%	Explore
CD4-positive, alpha-beta memory T cell	7 studies	49% ± 23%	Explore
leukocyte	7 studies	40% ± 5%	Explore
vein endothelial cell	7 studies	31% ± 11%	Explore
mucosal invariant T cell	7 studies	34% ± 14%	Explore
myofibroblast cell	7 studies	36% ± 17%	Explore
innate lymphoid cell	7 studies	29% ± 7%	Explore
CD8-positive, alpha-beta memory T cell	7 studies	38% ± 16%	Explore
secretory cell	7 studies	35% ± 19%	Explore
oligodendrocyte precursor cell	7 studies	39% ± 17%	Explore
non-classical monocyte	6 studies	21% ± 10%	Explore
effector memory CD8-positive, alpha-beta T cell	6 studies	36% ± 14%	Explore
CD4-positive helper T cell	5 studies	43% ± 15%	Explore
mononuclear phagocyte	5 studies	32% ± 15%	Explore
CD16-negative, CD56-bright natural killer cell, human	5 studies	33% ± 5%	Explore
plasmablast	4 studies	20% ± 3%	Explore
connective tissue cell	4 studies	43% ± 11%	Explore
glial cell	4 studies	19% ± 3%	Explore
effector memory CD4-positive, alpha-beta T cell	4 studies	45% ± 11%	Explore
T follicular helper cell	4 studies	52% ± 12%	Explore
erythrocyte	4 studies	38% ± 8%	Explore
deuterosomal cell	3 studies	20% ± 0%	Explore
effector CD4-positive, alpha-beta T cell	3 studies	50% ± 21%	Explore
effector CD8-positive, alpha-beta T cell	3 studies	48% ± 6%	Explore
monocyte-derived dendritic cell	3 studies	50% ± 15%	Explore
platelet	3 studies	20% ± 5%	Explore
IgA plasma cell	3 studies	23% ± 3%	Explore
IgG plasma cell	3 studies	20% ± 3%	Explore
epithelial cell	3 studies	35% ± 6%	Explore
mucus secreting cell	3 studies	32% ± 1%	Explore
memory B cell	3 studies	25% ± 9%	Explore
intermediate monocyte	3 studies	36% ± 14%	Explore
luminal cell of prostate epithelium	3 studies	21% ± 3%	Explore
abnormal cell	3 studies	23% ± 7%	Explore
CD16-positive, CD56-dim natural killer cell, human	3 studies	22% ± 5%	Explore
progenitor cell of mammary luminal epithelium	3 studies	48% ± 8%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	17 studies	32% ± 10%	Explore
peripheral blood	8 studies	27% ± 13%	Explore
brain	8 studies	26% ± 10%	Explore
intestine	5 studies	25% ± 7%	Explore
uterus	4 studies	26% ± 5%	Explore
breast	4 studies	32% ± 11%	Explore
lymph node	4 studies	30% ± 9%	Explore
kidney	3 studies	24% ± 4%	Explore
prostate	3 studies	40% ± 3%	Explore
liver	3 studies	49% ± 20%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	100%	3795.72	2633 / 2642	100%	411.79	705 / 705
thymus	99%	6415.92	646 / 653	98%	196.29	593 / 605
lung	100%	28862.53	578 / 578	95%	109.41	1095 / 1155
breast	99%	5218.47	453 / 459	89%	66.12	998 / 1118
prostate	91%	2638.16	224 / 245	76%	55.56	382 / 502
uterus	80%	1736.51	136 / 170	77%	54.74	355 / 459
bladder	90%	1523.86	19 / 21	64%	42.86	323 / 504
esophagus	63%	1104.55	914 / 1445	87%	63.17	159 / 183
kidney	78%	1873.57	69 / 89	72%	182.49	649 / 901
stomach	66%	972.48	238 / 359	75%	49.53	214 / 286
intestine	66%	1107.79	642 / 966	61%	42.49	323 / 527
skin	83%	2524.40	1504 / 1809	31%	16.31	146 / 472
pancreas	13%	140.07	41 / 328	94%	87.06	167 / 178
adrenal gland	30%	534.34	78 / 258	73%	99.20	167 / 230
adipose	100%	5984.23	1203 / 1204	0%	0	0 / 0
ovary	8%	129.32	15 / 180	88%	89.97	379 / 430
heart	95%	2470.72	817 / 861	0%	0	0 / 0
lymph node	0%	0	0 / 0	93%	74.05	27 / 29
tonsil	0%	0	0 / 0	89%	101.90	40 / 45
blood vessel	86%	2599.38	1144 / 1335	0%	0	0 / 0
spleen	80%	1384.46	193 / 241	0%	0	0 / 0
muscle	57%	888.50	461 / 803	0%	0	0 / 0
liver	3%	30.07	7 / 226	46%	22.46	186 / 406
peripheral blood	34%	485.72	315 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	8%	2.79	6 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0008285	Biological process	negative regulation of cell population proliferation
GO_0072537	Biological process	fibroblast activation
GO_0051091	Biological process	positive regulation of DNA-binding transcription factor activity
GO_0051496	Biological process	positive regulation of stress fiber assembly
GO_0090272	Biological process	negative regulation of fibroblast growth factor production
GO_0001100	Biological process	negative regulation of exit from mitosis
GO_0010628	Biological process	positive regulation of gene expression
GO_0003331	Biological process	positive regulation of extracellular matrix constituent secretion
GO_0045737	Biological process	positive regulation of cyclin-dependent protein serine/threonine kinase activity
GO_0006956	Biological process	complement activation
GO_0043537	Biological process	negative regulation of blood vessel endothelial cell migration
GO_0016525	Biological process	negative regulation of angiogenesis
GO_1900087	Biological process	positive regulation of G1/S transition of mitotic cell cycle
GO_1901203	Biological process	positive regulation of extracellular matrix assembly
GO_0001937	Biological process	negative regulation of endothelial cell proliferation
GO_0032967	Biological process	positive regulation of collagen biosynthetic process
GO_2000573	Biological process	positive regulation of DNA biosynthetic process
GO_0001818	Biological process	negative regulation of cytokine production
GO_0010718	Biological process	positive regulation of epithelial to mesenchymal transition
GO_1901991	Biological process	negative regulation of mitotic cell cycle phase transition
GO_0001819	Biological process	positive regulation of cytokine production
GO_2000048	Biological process	negative regulation of cell-cell adhesion mediated by cadherin
GO_2000353	Biological process	positive regulation of endothelial cell apoptotic process
GO_0045840	Biological process	positive regulation of mitotic nuclear division
GO_0071456	Biological process	cellular response to hypoxia
GO_0045944	Biological process	positive regulation of transcription by RNA polymerase II
GO_0005730	Cellular component	nucleolus
GO_0005813	Cellular component	centrosome
GO_0005654	Cellular component	nucleoplasm
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0005634	Cellular component	nucleus
GO_0070412	Molecular function	R-SMAD binding
GO_0019901	Molecular function	protein kinase binding
GO_0030295	Molecular function	protein kinase activator activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	RGCC
Protein name	Regulator of cell cycle RGCC (Response gene to complement 32 protein) (RGC-32)
Synonyms	RGC32 C13orf15
Description	FUNCTION: Modulates the activity of cell cycle-specific kinases. Enhances CDK1 activity. May contribute to the regulation of the cell cycle. May inhibit growth of glioma cells by promoting arrest of mitotic progression at the G2/M transition. Fibrogenic factor contributing to the pathogenesis of renal fibrosis through fibroblast activation. .
Accessions	ENST00000379359.4 [Q9H4X1-1] Q9H4X1

RGCC report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review