Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 26 studies | 40% ± 15% | |
astrocyte | 19 studies | 59% ± 20% | |
ciliated cell | 18 studies | 58% ± 19% | |
oligodendrocyte | 14 studies | 36% ± 13% | |
oligodendrocyte precursor cell | 14 studies | 51% ± 17% | |
microglial cell | 13 studies | 48% ± 11% | |
glutamatergic neuron | 12 studies | 63% ± 22% | |
GABAergic neuron | 11 studies | 56% ± 22% | |
pericyte | 10 studies | 32% ± 15% | |
macrophage | 9 studies | 37% ± 13% | |
fibroblast | 9 studies | 31% ± 12% | |
epithelial cell | 8 studies | 34% ± 19% | |
mast cell | 8 studies | 26% ± 8% | |
neuron | 7 studies | 50% ± 24% | |
endothelial cell of lymphatic vessel | 7 studies | 42% ± 11% | |
interneuron | 6 studies | 66% ± 15% | |
smooth muscle cell | 6 studies | 27% ± 8% | |
B cell | 5 studies | 35% ± 9% | |
T cell | 5 studies | 25% ± 7% | |
monocyte | 5 studies | 25% ± 6% | |
type I pneumocyte | 5 studies | 28% ± 6% | |
type II pneumocyte | 5 studies | 26% ± 6% | |
granule cell | 4 studies | 60% ± 18% | |
adipocyte | 4 studies | 21% ± 2% | |
dendritic cell | 4 studies | 22% ± 4% | |
mesothelial cell | 4 studies | 31% ± 8% | |
Mueller cell | 4 studies | 50% ± 27% | |
amacrine cell | 4 studies | 38% ± 21% | |
retinal cone cell | 4 studies | 48% ± 22% | |
retinal rod cell | 4 studies | 52% ± 16% | |
enteroendocrine cell | 4 studies | 43% ± 22% | |
club cell | 4 studies | 28% ± 8% | |
differentiation-committed oligodendrocyte precursor | 3 studies | 51% ± 4% | |
GABAergic interneuron | 3 studies | 53% ± 6% | |
progenitor cell | 3 studies | 47% ± 20% | |
CD4-positive, alpha-beta T cell | 3 studies | 20% ± 1% | |
CD8-positive, alpha-beta T cell | 3 studies | 21% ± 4% | |
vein endothelial cell | 3 studies | 45% ± 26% | |
GABAergic amacrine cell | 3 studies | 50% ± 20% | |
glycinergic amacrine cell | 3 studies | 42% ± 19% | |
retina horizontal cell | 3 studies | 46% ± 23% | |
abnormal cell | 3 studies | 29% ± 15% | |
myeloid cell | 3 studies | 23% ± 0% | |
endothelial cell of vascular tree | 3 studies | 46% ± 21% | |
retinal pigment epithelial cell | 3 studies | 33% ± 19% | |
ependymal cell | 3 studies | 86% ± 8% | |
capillary endothelial cell | 3 studies | 36% ± 5% | |
endothelial cell of artery | 3 studies | 39% ± 15% | |
natural killer cell | 3 studies | 25% ± 3% | |
lymphocyte | 3 studies | 37% ± 9% | |
basal cell | 3 studies | 33% ± 16% | |
mucus secreting cell | 3 studies | 22% ± 5% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
brain | 100% | 1611.82 | 2639 / 2642 | 100% | 13.46 | 702 / 705 |
prostate | 100% | 1292.74 | 244 / 245 | 97% | 8.86 | 486 / 502 |
ovary | 100% | 1428.46 | 180 / 180 | 86% | 4.87 | 370 / 430 |
thymus | 100% | 1150.34 | 652 / 653 | 85% | 4.05 | 517 / 605 |
breast | 100% | 1420.86 | 459 / 459 | 84% | 5.22 | 940 / 1118 |
intestine | 100% | 1051.40 | 965 / 966 | 75% | 3.20 | 397 / 527 |
kidney | 100% | 656.54 | 89 / 89 | 73% | 3.34 | 655 / 901 |
pancreas | 95% | 472.28 | 313 / 328 | 75% | 3.03 | 134 / 178 |
stomach | 99% | 658.01 | 355 / 359 | 72% | 3.28 | 205 / 286 |
esophagus | 99% | 741.24 | 1426 / 1445 | 70% | 3.32 | 129 / 183 |
lung | 100% | 1641.86 | 577 / 578 | 69% | 3.21 | 797 / 1155 |
adrenal gland | 98% | 525.89 | 253 / 258 | 67% | 3.49 | 153 / 230 |
uterus | 100% | 1748.35 | 170 / 170 | 62% | 3.23 | 284 / 459 |
skin | 98% | 713.95 | 1774 / 1809 | 59% | 2.60 | 278 / 472 |
bladder | 100% | 878.48 | 21 / 21 | 57% | 2.50 | 287 / 504 |
spleen | 100% | 1251.78 | 241 / 241 | 0% | 0 | 0 / 0 |
adipose | 100% | 1162.68 | 1203 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 99% | 754.99 | 1325 / 1335 | 0% | 0 | 0 / 0 |
muscle | 98% | 822.50 | 785 / 803 | 0% | 0 | 0 / 0 |
peripheral blood | 92% | 900.99 | 857 / 929 | 0% | 0 | 0 / 0 |
heart | 84% | 395.28 | 726 / 861 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 69% | 2.67 | 20 / 29 |
tonsil | 0% | 0 | 0 / 0 | 58% | 2.39 | 26 / 45 |
liver | 25% | 70.27 | 56 / 226 | 14% | 0.51 | 58 / 406 |
eye | 0% | 0 | 0 / 0 | 25% | 0.75 | 20 / 80 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0060271 | Biological process | cilium assembly |
GO_0050796 | Biological process | regulation of insulin secretion |
GO_0060287 | Biological process | epithelial cilium movement involved in determination of left/right asymmetry |
GO_0006357 | Biological process | regulation of transcription by RNA polymerase II |
GO_0060285 | Biological process | cilium-dependent cell motility |
GO_0072560 | Biological process | type B pancreatic cell maturation |
GO_2000078 | Biological process | positive regulation of type B pancreatic cell development |
GO_0006351 | Biological process | DNA-templated transcription |
GO_0045893 | Biological process | positive regulation of DNA-templated transcription |
GO_0006355 | Biological process | regulation of DNA-templated transcription |
GO_0031018 | Biological process | endocrine pancreas development |
GO_0048469 | Biological process | cell maturation |
GO_0045892 | Biological process | negative regulation of DNA-templated transcription |
GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
GO_0005576 | Cellular component | extracellular region |
GO_0000785 | Cellular component | chromatin |
GO_0005667 | Cellular component | transcription regulator complex |
GO_0005634 | Cellular component | nucleus |
GO_0003677 | Molecular function | DNA binding |
GO_0000978 | Molecular function | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
GO_0000981 | Molecular function | DNA-binding transcription factor activity, RNA polymerase II-specific |
GO_0000976 | Molecular function | transcription cis-regulatory region binding |
GO_1990837 | Molecular function | sequence-specific double-stranded DNA binding |
GO_0003700 | Molecular function | DNA-binding transcription factor activity |
GO_0005515 | Molecular function | protein binding |
Gene name | RFX3 |
Protein name | Regulatory factor X3 Transcription factor RFX3 (Regulatory factor X 3) |
Synonyms | |
Description | FUNCTION: Transcription factor required for ciliogenesis and islet cell differentiation during endocrine pancreas development. Essential for the differentiation of nodal monocilia and left-right asymmetry specification during embryogenesis. Required for the biogenesis of motile cilia by governing growth and beating efficiency of motile cells. Also required for ciliated ependymal cell differentiation. Regulates the expression of genes involved in ciliary assembly (DYNC2LI1, FOXJ1 and BBS4) and genes involved in ciliary motility (DNAH11, DNAH9 and DNAH5) (By similarity). Together with RFX6, participates in the differentiation of 4 of the 5 islet cell types during endocrine pancreas development, with the exception of pancreatic PP (polypeptide-producing) cells. Regulates transcription by forming a heterodimer with another RFX protein and binding to the X-box in the promoter of target genes . Represses transcription of MAP1A in non-neuronal cells but not in neuronal cells . . |
Accessions | H0Y7Z4 ENST00000442560.5 ENST00000449234.1 F6XM74 ENST00000458034.1 ENST00000358730.6 [P48380-2] P48380 ENST00000382004.7 [P48380-1] ENST00000420720.5 ENST00000451859.5 ENST00000381984.2 ENST00000457373.5 F6UV76 H0Y790 F6UGA0 ENST00000302303.5 [P48380-3] A9Z1Z2 ENST00000449190.5 ENST00000617270.5 [P48380-1] H0Y7W5 F6USP3 |