RFX3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0060271Biological processcilium assembly
GO_0050796Biological processregulation of insulin secretion
GO_0060287Biological processepithelial cilium movement involved in determination of left/right asymmetry
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0060285Biological processcilium-dependent cell motility
GO_0072560Biological processtype B pancreatic cell maturation
GO_2000078Biological processpositive regulation of type B pancreatic cell development
GO_0006351Biological processDNA-templated transcription
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0006355Biological processregulation of DNA-templated transcription
GO_0031018Biological processendocrine pancreas development
GO_0048469Biological processcell maturation
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005576Cellular componentextracellular region
GO_0000785Cellular componentchromatin
GO_0005667Cellular componenttranscription regulator complex
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0000976Molecular functiontranscription cis-regulatory region binding
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0003700Molecular functionDNA-binding transcription factor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameRFX3
Protein nameRegulatory factor X3
Transcription factor RFX3 (Regulatory factor X 3)
Synonyms
DescriptionFUNCTION: Transcription factor required for ciliogenesis and islet cell differentiation during endocrine pancreas development. Essential for the differentiation of nodal monocilia and left-right asymmetry specification during embryogenesis. Required for the biogenesis of motile cilia by governing growth and beating efficiency of motile cells. Also required for ciliated ependymal cell differentiation. Regulates the expression of genes involved in ciliary assembly (DYNC2LI1, FOXJ1 and BBS4) and genes involved in ciliary motility (DNAH11, DNAH9 and DNAH5) (By similarity). Together with RFX6, participates in the differentiation of 4 of the 5 islet cell types during endocrine pancreas development, with the exception of pancreatic PP (polypeptide-producing) cells. Regulates transcription by forming a heterodimer with another RFX protein and binding to the X-box in the promoter of target genes . Represses transcription of MAP1A in non-neuronal cells but not in neuronal cells . .

AccessionsH0Y7Z4
ENST00000442560.5
ENST00000449234.1
F6XM74
ENST00000458034.1
ENST00000358730.6 [P48380-2]
P48380
ENST00000382004.7 [P48380-1]
ENST00000420720.5
ENST00000451859.5
ENST00000381984.2
ENST00000457373.5
F6UV76
H0Y790
F6UGA0
ENST00000302303.5 [P48380-3]
A9Z1Z2
ENST00000449190.5
ENST00000617270.5 [P48380-1]
H0Y7W5
F6USP3