RBM22 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0071466Biological processcellular response to xenobiotic stimulus
GO_0033120Biological processpositive regulation of RNA splicing
GO_0042307Biological processpositive regulation of protein import into nucleus
GO_0046827Biological processpositive regulation of protein export from nucleus
GO_0000398Biological processmRNA splicing, via spliceosome
GO_0045292Biological processmRNA cis splicing, via spliceosome
GO_0005654Cellular componentnucleoplasm
GO_0071007Cellular componentU2-type catalytic step 2 spliceosome
GO_0000974Cellular componentPrp19 complex
GO_0071006Cellular componentU2-type catalytic step 1 spliceosome
GO_0005737Cellular componentcytoplasm
GO_0071013Cellular componentcatalytic step 2 spliceosome
GO_0005634Cellular componentnucleus
GO_0017070Molecular functionU6 snRNA binding
GO_0048306Molecular functioncalcium-dependent protein binding
GO_0046872Molecular functionmetal ion binding
GO_0003723Molecular functionRNA binding
GO_0036002Molecular functionpre-mRNA binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameRBM22
Protein namePre-mRNA-splicing factor RBM22 (RNA-binding motif protein 22) (Zinc finger CCCH domain-containing protein 16)
RNA binding motif protein 22
Synonyms199G4
ZC3H16
DescriptionFUNCTION: Required for pre-mRNA splicing as component of the activated spliceosome . Involved in the first step of pre-mRNA splicing. Binds directly to the internal stem-loop (ISL) domain of the U6 snRNA and to the pre-mRNA intron near the 5' splice site during the activation and catalytic phases of the spliceosome cycle. Involved in both translocations of the nuclear SLU7 to the cytoplasm and the cytosolic calcium-binding protein PDCD6 to the nucleus upon cellular stress responses. .

AccessionsE5RHA8
ENST00000521464.1
E5RJW4
ENST00000199814.9 [Q9NW64-1]
Q9NW64
ENST00000518917.5
ENST00000447771.6 [Q9NW64-2]