RAB8B | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	33 studies	27% ± 10%	Explore
macrophage	20 studies	30% ± 14%	Explore
fibroblast	19 studies	27% ± 9%	Explore
CD8-positive, alpha-beta T cell	18 studies	20% ± 4%	Explore
T cell	15 studies	23% ± 8%	Explore
classical monocyte	15 studies	25% ± 10%	Explore
B cell	14 studies	20% ± 5%	Explore
regulatory T cell	14 studies	22% ± 5%	Explore
dendritic cell	13 studies	40% ± 13%	Explore
CD16-positive, CD56-dim natural killer cell, human	13 studies	27% ± 7%	Explore
monocyte	12 studies	27% ± 8%	Explore
gamma-delta T cell	11 studies	27% ± 9%	Explore
endothelial cell	10 studies	26% ± 10%	Explore
pericyte	10 studies	25% ± 12%	Explore
CD16-negative, CD56-bright natural killer cell, human	10 studies	29% ± 8%	Explore
mature NK T cell	10 studies	23% ± 8%	Explore
myeloid cell	10 studies	31% ± 9%	Explore
mast cell	9 studies	22% ± 6%	Explore
naive B cell	9 studies	21% ± 5%	Explore
microglial cell	9 studies	25% ± 7%	Explore
oligodendrocyte precursor cell	9 studies	26% ± 11%	Explore
mucosal invariant T cell	9 studies	21% ± 6%	Explore
oligodendrocyte	9 studies	23% ± 7%	Explore
endothelial cell of lymphatic vessel	8 studies	28% ± 7%	Explore
non-classical monocyte	8 studies	26% ± 9%	Explore
CD4-positive, alpha-beta T cell	8 studies	21% ± 2%	Explore
effector memory CD8-positive, alpha-beta T cell	8 studies	22% ± 5%	Explore
GABAergic neuron	7 studies	34% ± 15%	Explore
leukocyte	6 studies	29% ± 9%	Explore
mononuclear phagocyte	6 studies	24% ± 8%	Explore
astrocyte	6 studies	26% ± 8%	Explore
CD8-positive, alpha-beta memory T cell	6 studies	28% ± 5%	Explore
innate lymphoid cell	5 studies	28% ± 10%	Explore
epithelial cell	5 studies	20% ± 7%	Explore
lymphocyte	5 studies	37% ± 15%	Explore
glutamatergic neuron	5 studies	35% ± 13%	Explore
interneuron	5 studies	33% ± 17%	Explore
neutrophil	4 studies	30% ± 13%	Explore
effector CD8-positive, alpha-beta T cell	4 studies	20% ± 5%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	4 studies	18% ± 2%	Explore
conventional dendritic cell	4 studies	28% ± 7%	Explore
neuron	4 studies	26% ± 10%	Explore
memory B cell	4 studies	20% ± 5%	Explore
smooth muscle cell	3 studies	19% ± 1%	Explore
hematopoietic precursor cell	3 studies	27% ± 13%	Explore
progenitor cell	3 studies	24% ± 6%	Explore
exhausted T cell	3 studies	16% ± 2%	Explore
CD4-positive, alpha-beta memory T cell	3 studies	24% ± 7%	Explore
adipocyte	3 studies	24% ± 4%	Explore
adventitial cell	3 studies	23% ± 6%	Explore
vein endothelial cell	3 studies	30% ± 16%	Explore
myofibroblast cell	3 studies	19% ± 3%	Explore
alveolar macrophage	3 studies	39% ± 10%	Explore
group 3 innate lymphoid cell	3 studies	35% ± 14%	Explore
double negative thymocyte	3 studies	20% ± 5%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	3 studies	25% ± 5%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	9 studies	27% ± 11%	Explore
lung	5 studies	27% ± 7%	Explore
peripheral blood	5 studies	25% ± 7%	Explore
liver	5 studies	17% ± 2%	Explore
adipose	3 studies	20% ± 2%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
prostate	100%	2247.56	244 / 245	100%	26.94	501 / 502
brain	99%	1684.49	2616 / 2642	100%	36.57	705 / 705
lung	100%	5289.27	578 / 578	99%	21.39	1142 / 1155
breast	100%	2837.06	459 / 459	99%	22.76	1102 / 1118
thymus	100%	2210.83	651 / 653	99%	21.74	598 / 605
bladder	100%	3315.00	21 / 21	98%	18.19	493 / 504
kidney	100%	1579.92	89 / 89	97%	28.40	878 / 901
esophagus	98%	1769.71	1422 / 1445	98%	18.08	180 / 183
uterus	100%	2736.31	170 / 170	96%	15.95	440 / 459
adrenal gland	100%	1927.30	258 / 258	95%	17.86	218 / 230
skin	99%	2417.66	1783 / 1809	95%	30.50	448 / 472
intestine	100%	2374.57	964 / 966	91%	14.14	478 / 527
ovary	100%	3489.39	180 / 180	86%	8.77	369 / 430
stomach	94%	1368.78	336 / 359	92%	16.44	262 / 286
liver	75%	703.19	170 / 226	77%	10.63	313 / 406
pancreas	42%	335.13	138 / 328	98%	26.13	175 / 178
adipose	100%	3829.21	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	47.33	29 / 29
spleen	100%	3682.06	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	15.08	1 / 1
blood vessel	100%	2854.10	1334 / 1335	0%	0	0 / 0
peripheral blood	100%	6734.41	926 / 929	0%	0	0 / 0
tonsil	0%	0	0 / 0	96%	17.34	43 / 45
heart	85%	1456.05	735 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	65%	7.17	52 / 80
muscle	63%	636.27	508 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0060271	Biological process	cilium assembly
GO_0150115	Biological process	cell-substrate junction organization
GO_0045046	Biological process	protein import into peroxisome membrane
GO_0009306	Biological process	protein secretion
GO_0031346	Biological process	positive regulation of cell projection organization
GO_0032456	Biological process	endocytic recycling
GO_0006887	Biological process	exocytosis
GO_0019882	Biological process	antigen processing and presentation
GO_0051461	Biological process	positive regulation of corticotropin secretion
GO_0005778	Cellular component	peroxisomal membrane
GO_0005886	Cellular component	plasma membrane
GO_0048471	Cellular component	perinuclear region of cytoplasm
GO_0051286	Cellular component	cell tip
GO_0070062	Cellular component	extracellular exosome
GO_0055038	Cellular component	recycling endosome membrane
GO_0008021	Cellular component	synaptic vesicle
GO_0045335	Cellular component	phagocytic vesicle
GO_0030140	Cellular component	trans-Golgi network transport vesicle
GO_0030670	Cellular component	phagocytic vesicle membrane
GO_0010008	Cellular component	endosome membrane
GO_0005768	Cellular component	endosome
GO_0019003	Molecular function	GDP binding
GO_0030911	Molecular function	TPR domain binding
GO_0005102	Molecular function	signaling receptor binding
GO_0005525	Molecular function	GTP binding
GO_0005515	Molecular function	protein binding
GO_0003924	Molecular function	GTPase activity

IV. Literature review

[source]

Gene name	RAB8B
Protein name	Ras-related protein Rab-8B
Synonyms
Description	FUNCTION: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab may be involved in polarized vesicular trafficking and neurotransmitter release. May participate in cell junction dynamics in Sertoli cells (By similarity). May participate in the export of a subset of neosynthesized proteins through a Rab8-Rab10-Rab11-dependent endososomal export route . .
Accessions	ENST00000321437.9 H0YMN7 ENST00000558990.5 ENST00000558119.5 ENST00000559006.1 Q92930 H0YNE9 H0YL94 ENST00000559927.1 H0YLJ8

RAB8B report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review