RAB5IF | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	29 studies	30% ± 11%	Explore
classical monocyte	20 studies	43% ± 15%	Explore
conventional dendritic cell	19 studies	27% ± 15%	Explore
non-classical monocyte	19 studies	37% ± 15%	Explore
CD8-positive, alpha-beta T cell	19 studies	28% ± 11%	Explore
monocyte	17 studies	35% ± 10%	Explore
macrophage	17 studies	29% ± 13%	Explore
T cell	16 studies	25% ± 6%	Explore
regulatory T cell	15 studies	24% ± 7%	Explore
B cell	13 studies	21% ± 7%	Explore
CD4-positive, alpha-beta T cell	13 studies	26% ± 12%	Explore
plasmacytoid dendritic cell	12 studies	30% ± 10%	Explore
gamma-delta T cell	12 studies	32% ± 13%	Explore
epithelial cell	12 studies	37% ± 18%	Explore
mature NK T cell	11 studies	28% ± 5%	Explore
endothelial cell	11 studies	25% ± 10%	Explore
CD16-positive, CD56-dim natural killer cell, human	10 studies	40% ± 13%	Explore
plasma cell	9 studies	31% ± 10%	Explore
myeloid cell	9 studies	28% ± 9%	Explore
plasmablast	8 studies	43% ± 22%	Explore
CD8-positive, alpha-beta memory T cell	8 studies	32% ± 13%	Explore
dendritic cell	8 studies	38% ± 18%	Explore
CD16-negative, CD56-bright natural killer cell, human	8 studies	32% ± 4%	Explore
secretory cell	7 studies	26% ± 9%	Explore
mucosal invariant T cell	7 studies	23% ± 4%	Explore
club cell	6 studies	22% ± 4%	Explore
effector CD8-positive, alpha-beta T cell	6 studies	30% ± 9%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	6 studies	22% ± 4%	Explore
endothelial cell of lymphatic vessel	6 studies	19% ± 3%	Explore
CD4-positive, alpha-beta memory T cell	5 studies	28% ± 7%	Explore
basal cell	5 studies	35% ± 15%	Explore
effector memory CD8-positive, alpha-beta T cell	5 studies	28% ± 6%	Explore
fibroblast	5 studies	25% ± 9%	Explore
effector memory CD4-positive, alpha-beta T cell	5 studies	26% ± 11%	Explore
alveolar macrophage	4 studies	27% ± 5%	Explore
hematopoietic precursor cell	4 studies	31% ± 8%	Explore
neutrophil	4 studies	26% ± 7%	Explore
respiratory goblet cell	4 studies	31% ± 10%	Explore
squamous epithelial cell	4 studies	45% ± 21%	Explore
leukocyte	4 studies	28% ± 8%	Explore
mononuclear phagocyte	4 studies	29% ± 15%	Explore
exhausted T cell	4 studies	32% ± 6%	Explore
epithelial cell of proximal tubule	4 studies	19% ± 4%	Explore
smooth muscle cell	4 studies	18% ± 4%	Explore
innate lymphoid cell	4 studies	25% ± 6%	Explore
ciliated cell	4 studies	35% ± 7%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	24% ± 7%	Explore
enterocyte	4 studies	19% ± 4%	Explore
T follicular helper cell	4 studies	20% ± 2%	Explore
memory B cell	4 studies	18% ± 2%	Explore
duct epithelial cell	3 studies	26% ± 9%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	3 studies	19% ± 2%	Explore
endothelial cell of artery	3 studies	20% ± 3%	Explore
vein endothelial cell	3 studies	17% ± 1%	Explore
common myeloid progenitor	3 studies	32% ± 9%	Explore
myofibroblast cell	3 studies	19% ± 4%	Explore
pericyte	3 studies	21% ± 4%	Explore
capillary endothelial cell	3 studies	20% ± 3%	Explore
intraepithelial lymphocyte	3 studies	25% ± 7%	Explore
intermediate monocyte	3 studies	52% ± 18%	Explore
neuron	3 studies	26% ± 15%	Explore
enteroendocrine cell	3 studies	26% ± 10%	Explore
group 3 innate lymphoid cell	3 studies	24% ± 8%	Explore
transit amplifying cell	3 studies	20% ± 5%	Explore
T-helper 17 cell	3 studies	33% ± 19%	Explore
luminal hormone-sensing cell of mammary gland	3 studies	17% ± 1%	Explore
hepatocyte	3 studies	39% ± 18%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	12 studies	29% ± 8%	Explore
lung	10 studies	25% ± 8%	Explore
kidney	4 studies	22% ± 2%	Explore
intestine	4 studies	24% ± 11%	Explore
liver	4 studies	30% ± 20%	Explore
lymph node	3 studies	24% ± 10%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	3662.62	1443 / 1445	100%	23.75	183 / 183
ovary	99%	1038.39	179 / 180	100%	27.58	429 / 430
stomach	100%	1893.37	359 / 359	96%	30.96	274 / 286
intestine	100%	2304.33	966 / 966	84%	32.24	444 / 527
lung	100%	2539.27	576 / 578	73%	5.33	842 / 1155
bladder	100%	1797.19	21 / 21	68%	13.96	345 / 504
uterus	100%	1315.72	170 / 170	63%	4.08	291 / 459
pancreas	98%	1168.31	323 / 328	57%	2.28	101 / 178
liver	100%	3342.24	226 / 226	46%	2.01	186 / 406
brain	97%	1361.04	2575 / 2642	36%	1.62	257 / 705
breast	100%	1781.18	459 / 459	29%	1.07	326 / 1118
kidney	100%	2593.08	89 / 89	29%	1.33	262 / 901
skin	100%	2368.60	1805 / 1809	27%	1.02	127 / 472
adrenal gland	100%	2452.62	258 / 258	24%	0.68	56 / 230
prostate	100%	1623.80	244 / 245	22%	0.65	110 / 502
thymus	100%	1541.69	651 / 653	20%	1.12	123 / 605
adipose	100%	1967.30	1204 / 1204	0%	0	0 / 0
muscle	100%	5768.11	803 / 803	0%	0	0 / 0
peripheral blood	100%	7069.72	929 / 929	0%	0	0 / 0
spleen	100%	3135.27	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	2.20	1 / 1
blood vessel	99%	1448.52	1324 / 1335	0%	0	0 / 0
heart	93%	1423.74	802 / 861	0%	0	0 / 0
lymph node	0%	0	0 / 0	59%	2.59	17 / 29
tonsil	0%	0	0 / 0	47%	2.74	21 / 45
eye	0%	0	0 / 0	36%	1.15	29 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0160063	Biological process	multi-pass transmembrane protein insertion into ER membrane
GO_0097250	Biological process	mitochondrial respirasome assembly
GO_0005746	Cellular component	mitochondrial respirasome
GO_0160064	Cellular component	multi-pass translocon complex
GO_0005789	Cellular component	endoplasmic reticulum membrane
GO_0005515	Molecular function	protein binding
GO_0003674	Molecular function	molecular_function

IV. Literature review

[source]

Gene name	RAB5IF
Protein name	GEL complex subunit OPTI (Obligate partner of TMCO1 insertase) (Rab5-interacting protein) (RIP5) (Respirasome Complex Assembly Factor 1)
Synonyms	RCAF1 PNAS-11 OPTI C20orf24
Description	FUNCTION: Component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes . The MPT complex takes over after the SEC61 complex: following membrane insertion of the first few transmembrane segments of proteins by the SEC61 complex, the MPT complex occludes the lateral gate of the SEC61 complex to promote insertion of subsequent transmembrane regions . Within the MPT complex, the GEL subcomplex may mediate insertion of transmembrane regions into the membrane . In addition to its role in multi-pass membrane insertion, RAB5IF/OPTI also acts as an assembly factor for mitochondrial respiratory complexes . .
Accessions	ENST00000344795.8 [Q9BUV8-2] ENST00000373852.9 [Q9BUV8-1] Q9BUV8 ENST00000492721.5 [Q9BUV8-4] ENST00000483815.5 [Q9BUV8-4] ENST00000342422.3 [Q9BUV8-5]

RAB5IF report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review