R3HDM2 report

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I. Expression across cell types

Cell ontologyData table

Name	Number of supported studies	Average coverage
endothelial cell	21 studies	34% ± 13%	Explore
fibroblast	16 studies	26% ± 11%	Explore
astrocyte	15 studies	40% ± 18%	Explore
B cell	12 studies	28% ± 8%	Explore
smooth muscle cell	12 studies	26% ± 11%	Explore
glutamatergic neuron	12 studies	59% ± 26%	Explore
macrophage	12 studies	35% ± 13%	Explore
oligodendrocyte	12 studies	41% ± 14%	Explore
microglial cell	11 studies	42% ± 12%	Explore
oligodendrocyte precursor cell	11 studies	41% ± 18%	Explore
GABAergic neuron	10 studies	54% ± 25%	Explore
epithelial cell	10 studies	35% ± 18%	Explore
natural killer cell	9 studies	24% ± 7%	Explore
adipocyte	9 studies	45% ± 15%	Explore
T cell	8 studies	26% ± 7%	Explore
mast cell	8 studies	27% ± 13%	Explore
neuron	8 studies	41% ± 18%	Explore
amacrine cell	8 studies	34% ± 8%	Explore
myeloid cell	8 studies	34% ± 11%	Explore
pericyte	8 studies	29% ± 10%	Explore
endothelial cell of lymphatic vessel	7 studies	25% ± 7%	Explore
CD4-positive, alpha-beta T cell	7 studies	23% ± 5%	Explore
CD8-positive, alpha-beta T cell	7 studies	21% ± 5%	Explore
retinal ganglion cell	7 studies	41% ± 15%	Explore
basal cell	7 studies	32% ± 14%	Explore
retinal cone cell	7 studies	36% ± 10%	Explore
ciliated cell	7 studies	32% ± 9%	Explore
interneuron	6 studies	61% ± 24%	Explore
retina horizontal cell	6 studies	35% ± 5%	Explore
dendritic cell	6 studies	28% ± 8%	Explore
Mueller cell	6 studies	26% ± 7%	Explore
type I pneumocyte	6 studies	26% ± 7%	Explore
effector memory CD8-positive, alpha-beta T cell	5 studies	26% ± 5%	Explore
abnormal cell	5 studies	27% ± 18%	Explore
retinal bipolar neuron	5 studies	36% ± 8%	Explore
cardiac muscle cell	5 studies	49% ± 16%	Explore
retinal rod cell	5 studies	31% ± 10%	Explore
monocyte	5 studies	39% ± 8%	Explore
club cell	5 studies	31% ± 9%	Explore
type II pneumocyte	5 studies	30% ± 6%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	4 studies	26% ± 7%	Explore
non-classical monocyte	4 studies	30% ± 7%	Explore
CD16-positive, CD56-dim natural killer cell, human	4 studies	24% ± 4%	Explore
granule cell	4 studies	40% ± 8%	Explore
lymphocyte	4 studies	42% ± 8%	Explore
OFF-bipolar cell	4 studies	36% ± 3%	Explore
ON-bipolar cell	4 studies	35% ± 4%	Explore
endothelial cell of vascular tree	4 studies	23% ± 10%	Explore
connective tissue cell	4 studies	24% ± 7%	Explore
respiratory goblet cell	4 studies	36% ± 13%	Explore
naive B cell	4 studies	19% ± 2%	Explore
leukocyte	3 studies	30% ± 12%	Explore
CD16-negative, CD56-bright natural killer cell, human	3 studies	24% ± 4%	Explore
mature NK T cell	3 studies	24% ± 7%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	3 studies	25% ± 6%	Explore
GABAergic interneuron	3 studies	51% ± 8%	Explore
glial cell	3 studies	24% ± 3%	Explore
progenitor cell	3 studies	28% ± 4%	Explore
mononuclear phagocyte	3 studies	23% ± 3%	Explore
mucosal invariant T cell	3 studies	23% ± 6%	Explore
vein endothelial cell	3 studies	24% ± 11%	Explore
GABAergic amacrine cell	3 studies	38% ± 3%	Explore
glycinergic amacrine cell	3 studies	36% ± 1%	Explore
rod bipolar cell	3 studies	52% ± 7%	Explore
hepatocyte	3 studies	67% ± 19%	Explore
retinal pigment epithelial cell	3 studies	35% ± 17%	Explore
ependymal cell	3 studies	44% ± 13%	Explore
adventitial cell	3 studies	19% ± 4%	Explore
myofibroblast cell	3 studies	29% ± 8%	Explore
alveolar macrophage	3 studies	41% ± 10%	Explore
CD8-positive, alpha-beta memory T cell	3 studies	22% ± 3%	Explore
gamma-delta T cell	3 studies	22% ± 4%	Explore
regulatory T cell	3 studies	20% ± 1%	Explore
goblet cell	3 studies	35% ± 20%	Explore
transit amplifying cell	3 studies	35% ± 23%	Explore
mesothelial cell	3 studies	36% ± 5%	Explore
mural cell	3 studies	35% ± 15%	Explore
mucus secreting cell	3 studies	27% ± 6%	Explore

II. Expression across tissues

sc-RNAseq dataData table

Name	Number of supported studies	Average coverage
brain	17 studies	46% ± 23%	Explore
lung	8 studies	27% ± 10%	Explore
eye	8 studies	33% ± 11%	Explore
heart	5 studies	33% ± 14%	Explore
peripheral blood	4 studies	27% ± 8%	Explore
intestine	4 studies	19% ± 3%	Explore
liver	3 studies	39% ± 18%	Explore
adipose	3 studies	43% ± 15%	Explore
kidney	3 studies	26% ± 8%	Explore

Bulk RNAseq dataData table

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
adrenal gland	100%	4465.62	258 / 258	100%	24.63	230 / 230
esophagus	100%	3847.34	1445 / 1445	100%	20.85	183 / 183
ovary	100%	6633.37	180 / 180	100%	21.15	430 / 430
prostate	100%	5590.35	245 / 245	100%	29.38	502 / 502
stomach	100%	3233.87	359 / 359	100%	18.59	286 / 286
thymus	100%	5176.61	653 / 653	100%	23.35	605 / 605
brain	100%	5480.08	2640 / 2642	100%	23.12	705 / 705
breast	100%	4916.05	459 / 459	100%	22.61	1117 / 1118
skin	100%	5412.13	1809 / 1809	100%	17.11	471 / 472
uterus	100%	5469.26	170 / 170	100%	19.21	458 / 459
intestine	100%	4489.84	966 / 966	100%	18.22	525 / 527
bladder	100%	4073.95	21 / 21	100%	18.93	502 / 504
lung	100%	4503.41	578 / 578	100%	19.29	1150 / 1155
liver	100%	3903.27	226 / 226	100%	15.41	404 / 406
kidney	100%	3624.37	89 / 89	99%	17.79	895 / 901
pancreas	99%	2529.47	326 / 328	99%	19.05	177 / 178
adipose	100%	4652.30	1204 / 1204	0%	0	0 / 0
blood vessel	100%	3939.26	1335 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	100%	21.74	80 / 80
lymph node	0%	0	0 / 0	100%	12.58	29 / 29
muscle	100%	4018.38	803 / 803	0%	0	0 / 0
spleen	100%	5224.68	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	15.51	45 / 45
ureter	0%	0	0 / 0	100%	10.53	1 / 1
heart	98%	3494.07	846 / 861	0%	0	0 / 0
peripheral blood	96%	2867.90	896 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0