Name | Number of supported studies | Average coverage | |
---|---|---|---|
macrophage | 19 studies | 44% ± 22% | |
oligodendrocyte precursor cell | 15 studies | 55% ± 21% | |
astrocyte | 14 studies | 42% ± 20% | |
microglial cell | 13 studies | 69% ± 18% | |
oligodendrocyte | 13 studies | 46% ± 19% | |
GABAergic neuron | 10 studies | 51% ± 20% | |
glutamatergic neuron | 10 studies | 41% ± 23% | |
myeloid cell | 10 studies | 46% ± 19% | |
non-classical monocyte | 9 studies | 28% ± 15% | |
endothelial cell | 9 studies | 27% ± 16% | |
dendritic cell | 8 studies | 43% ± 18% | |
natural killer cell | 7 studies | 33% ± 14% | |
epithelial cell | 6 studies | 37% ± 19% | |
interneuron | 6 studies | 59% ± 20% | |
monocyte | 6 studies | 51% ± 16% | |
T cell | 6 studies | 31% ± 4% | |
leukocyte | 5 studies | 54% ± 20% | |
CD16-positive, CD56-dim natural killer cell, human | 5 studies | 27% ± 13% | |
neuron | 5 studies | 45% ± 19% | |
type I pneumocyte | 5 studies | 33% ± 12% | |
type II pneumocyte | 5 studies | 33% ± 9% | |
classical monocyte | 4 studies | 29% ± 6% | |
platelet | 4 studies | 25% ± 8% | |
B cell | 4 studies | 28% ± 10% | |
CD8-positive, alpha-beta T cell | 4 studies | 35% ± 11% | |
Mueller cell | 4 studies | 45% ± 6% | |
retinal cone cell | 4 studies | 29% ± 8% | |
club cell | 4 studies | 33% ± 10% | |
differentiation-committed oligodendrocyte precursor | 3 studies | 55% ± 6% | |
GABAergic interneuron | 3 studies | 49% ± 6% | |
granule cell | 3 studies | 45% ± 11% | |
CD4-positive, alpha-beta T cell | 3 studies | 31% ± 9% | |
effector memory CD8-positive, alpha-beta T cell | 3 studies | 26% ± 5% | |
GABAergic amacrine cell | 3 studies | 25% ± 5% | |
hepatocyte | 3 studies | 54% ± 19% | |
amacrine cell | 3 studies | 18% ± 2% | |
retinal pigment epithelial cell | 3 studies | 27% ± 12% | |
alveolar macrophage | 3 studies | 54% ± 14% | |
respiratory goblet cell | 3 studies | 38% ± 17% | |
lymphocyte | 3 studies | 47% ± 6% | |
brush cell | 3 studies | 62% ± 25% | |
renal alpha-intercalated cell | 3 studies | 57% ± 30% | |
mucus secreting cell | 3 studies | 43% ± 19% | |
regulatory T cell | 3 studies | 44% ± 13% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
prostate | 100% | 2665.80 | 244 / 245 | 100% | 30.44 | 501 / 502 |
kidney | 100% | 3390.57 | 89 / 89 | 99% | 30.07 | 890 / 901 |
thymus | 100% | 4632.85 | 653 / 653 | 98% | 25.75 | 595 / 605 |
brain | 99% | 1939.09 | 2610 / 2642 | 99% | 23.53 | 701 / 705 |
stomach | 100% | 3352.89 | 358 / 359 | 98% | 22.36 | 281 / 286 |
intestine | 100% | 2622.73 | 966 / 966 | 97% | 20.77 | 512 / 527 |
liver | 100% | 2390.37 | 226 / 226 | 94% | 14.48 | 383 / 406 |
lung | 100% | 3055.75 | 576 / 578 | 94% | 17.35 | 1087 / 1155 |
pancreas | 98% | 1348.69 | 321 / 328 | 95% | 23.01 | 169 / 178 |
skin | 94% | 1228.12 | 1702 / 1809 | 99% | 61.46 | 465 / 472 |
breast | 95% | 1167.92 | 434 / 459 | 96% | 19.68 | 1078 / 1118 |
bladder | 100% | 1163.38 | 21 / 21 | 62% | 9.79 | 310 / 504 |
esophagus | 75% | 876.98 | 1083 / 1445 | 81% | 16.49 | 149 / 183 |
uterus | 73% | 590.54 | 124 / 170 | 67% | 7.53 | 307 / 459 |
adrenal gland | 76% | 664.49 | 197 / 258 | 61% | 11.36 | 141 / 230 |
ovary | 38% | 273.48 | 69 / 180 | 85% | 11.78 | 367 / 430 |
eye | 0% | 0 | 0 / 0 | 100% | 68.45 | 80 / 80 |
spleen | 100% | 7399.52 | 241 / 241 | 0% | 0 | 0 / 0 |
adipose | 98% | 1266.23 | 1180 / 1204 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 97% | 35.00 | 28 / 29 |
peripheral blood | 94% | 8013.40 | 874 / 929 | 0% | 0 | 0 / 0 |
blood vessel | 86% | 991.14 | 1154 / 1335 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 78% | 9.78 | 35 / 45 |
heart | 69% | 535.40 | 595 / 861 | 0% | 0 | 0 / 0 |
muscle | 37% | 370.81 | 300 / 803 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0010642 | Biological process | negative regulation of platelet-derived growth factor receptor signaling pathway |
GO_0019221 | Biological process | cytokine-mediated signaling pathway |
GO_0001525 | Biological process | angiogenesis |
GO_0008285 | Biological process | negative regulation of cell population proliferation |
GO_0050766 | Biological process | positive regulation of phagocytosis |
GO_0006470 | Biological process | protein dephosphorylation |
GO_0050850 | Biological process | positive regulation of calcium-mediated signaling |
GO_0042059 | Biological process | negative regulation of epidermal growth factor receptor signaling pathway |
GO_0007507 | Biological process | heart development |
GO_0050860 | Biological process | negative regulation of T cell receptor signaling pathway |
GO_0050918 | Biological process | positive chemotaxis |
GO_0043116 | Biological process | negative regulation of vascular permeability |
GO_0060242 | Biological process | contact inhibition |
GO_0060369 | Biological process | positive regulation of Fc receptor mediated stimulatory signaling pathway |
GO_0001570 | Biological process | vasculogenesis |
GO_0035335 | Biological process | peptidyl-tyrosine dephosphorylation |
GO_0045785 | Biological process | positive regulation of cell adhesion |
GO_0007596 | Biological process | blood coagulation |
GO_0043410 | Biological process | positive regulation of MAPK cascade |
GO_0050852 | Biological process | T cell receptor signaling pathway |
GO_0046627 | Biological process | negative regulation of insulin receptor signaling pathway |
GO_0010759 | Biological process | positive regulation of macrophage chemotaxis |
GO_0051898 | Biological process | negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction |
GO_0048008 | Biological process | platelet-derived growth factor receptor signaling pathway |
GO_0050731 | Biological process | positive regulation of peptidyl-tyrosine phosphorylation |
GO_0051894 | Biological process | positive regulation of focal adhesion assembly |
GO_0048709 | Biological process | oligodendrocyte differentiation |
GO_0043407 | Biological process | negative regulation of MAP kinase activity |
GO_0051897 | Biological process | positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction |
GO_0030336 | Biological process | negative regulation of cell migration |
GO_0010572 | Biological process | positive regulation of platelet activation |
GO_0030155 | Biological process | regulation of cell adhesion |
GO_0030220 | Biological process | platelet formation |
GO_0032760 | Biological process | positive regulation of tumor necrosis factor production |
GO_0030183 | Biological process | B cell differentiation |
GO_0042593 | Biological process | glucose homeostasis |
GO_0030308 | Biological process | negative regulation of cell growth |
GO_0001772 | Cellular component | immunological synapse |
GO_0032587 | Cellular component | ruffle membrane |
GO_0035579 | Cellular component | specific granule membrane |
GO_0005886 | Cellular component | plasma membrane |
GO_0070062 | Cellular component | extracellular exosome |
GO_0005911 | Cellular component | cell-cell junction |
GO_0009986 | Cellular component | cell surface |
GO_0070097 | Molecular function | delta-catenin binding |
GO_0005161 | Molecular function | platelet-derived growth factor receptor binding |
GO_0045296 | Molecular function | cadherin binding |
GO_0019901 | Molecular function | protein kinase binding |
GO_0008013 | Molecular function | beta-catenin binding |
GO_0051019 | Molecular function | mitogen-activated protein kinase binding |
GO_0045295 | Molecular function | gamma-catenin binding |
GO_0016791 | Molecular function | phosphatase activity |
GO_0005515 | Molecular function | protein binding |
GO_0004725 | Molecular function | protein tyrosine phosphatase activity |
Gene name | PTPRJ |
Protein name | Protein tyrosine phosphatase receptor type J protein-tyrosine-phosphatase (EC 3.1.3.48) Receptor-type tyrosine-protein phosphatase eta (Protein-tyrosine phosphatase eta) (R-PTP-eta) (EC 3.1.3.48) (Density-enhanced phosphatase 1) (DEP-1) (HPTP eta) (Protein-tyrosine phosphatase receptor type J) (R-PTP-J) (CD antigen CD148) |
Synonyms | DEP1 |
Description | FUNCTION: Tyrosine phosphatase which dephosphorylates or contributes to the dephosphorylation of CTNND1, FLT3, PDGFRB, MET, KDR, LYN, SRC, MAPK1, MAPK3, EGFR, TJP1, OCLN, PIK3R1 and PIK3R2 . Plays a role in cell adhesion, migration, proliferation and differentiation . Involved in vascular development (By similarity). Regulator of macrophage adhesion and spreading (By similarity). Positively affects cell-matrix adhesion (By similarity). Positive regulator of platelet activation and thrombosis. Negative regulator of cell proliferation . Negative regulator of PDGF-stimulated cell migration; through dephosphorylation of PDGFR . Positive regulator of endothelial cell survival, as well as of VEGF-induced SRC and AKT activation; through KDR dephosphorylation . Negative regulator of EGFR signaling pathway; through EGFR dephosphorylation . Enhances the barrier function of epithelial junctions during reassembly . Negatively regulates T-cell receptor (TCR) signaling . Upon T-cell TCR activation, it is up-regulated and excluded from the immunological synapses, while upon T-cell-antigen presenting cells (APC) disengagement, it is no longer excluded and can dephosphorylate PLCG1 and LAT to down-regulate prolongation of signaling . .; FUNCTION: [Isoform 2]: Activates angiogenesis and cell migration . Downregulates the expression of the endothelial adhesion molecules ICAM1 and VCAM1 . . |
Accessions | E9PJ83 ENST00000534219.5 ENST00000418331.7 [Q12913-1] ENST00000527952.1 Q12913 ENST00000698881.1 E9PPH3 A0A8V8TP51 ENST00000440289.6 [Q12913-2] |