PTPRJ report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0010642Biological processnegative regulation of platelet-derived growth factor receptor signaling pathway
GO_0019221Biological processcytokine-mediated signaling pathway
GO_0001525Biological processangiogenesis
GO_0008285Biological processnegative regulation of cell population proliferation
GO_0050766Biological processpositive regulation of phagocytosis
GO_0006470Biological processprotein dephosphorylation
GO_0050850Biological processpositive regulation of calcium-mediated signaling
GO_0042059Biological processnegative regulation of epidermal growth factor receptor signaling pathway
GO_0007507Biological processheart development
GO_0050860Biological processnegative regulation of T cell receptor signaling pathway
GO_0050918Biological processpositive chemotaxis
GO_0043116Biological processnegative regulation of vascular permeability
GO_0060242Biological processcontact inhibition
GO_0060369Biological processpositive regulation of Fc receptor mediated stimulatory signaling pathway
GO_0001570Biological processvasculogenesis
GO_0035335Biological processpeptidyl-tyrosine dephosphorylation
GO_0045785Biological processpositive regulation of cell adhesion
GO_0007596Biological processblood coagulation
GO_0043410Biological processpositive regulation of MAPK cascade
GO_0050852Biological processT cell receptor signaling pathway
GO_0046627Biological processnegative regulation of insulin receptor signaling pathway
GO_0010759Biological processpositive regulation of macrophage chemotaxis
GO_0051898Biological processnegative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0048008Biological processplatelet-derived growth factor receptor signaling pathway
GO_0050731Biological processpositive regulation of peptidyl-tyrosine phosphorylation
GO_0051894Biological processpositive regulation of focal adhesion assembly
GO_0048709Biological processoligodendrocyte differentiation
GO_0043407Biological processnegative regulation of MAP kinase activity
GO_0051897Biological processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0030336Biological processnegative regulation of cell migration
GO_0010572Biological processpositive regulation of platelet activation
GO_0030155Biological processregulation of cell adhesion
GO_0030220Biological processplatelet formation
GO_0032760Biological processpositive regulation of tumor necrosis factor production
GO_0030183Biological processB cell differentiation
GO_0042593Biological processglucose homeostasis
GO_0030308Biological processnegative regulation of cell growth
GO_0001772Cellular componentimmunological synapse
GO_0032587Cellular componentruffle membrane
GO_0035579Cellular componentspecific granule membrane
GO_0005886Cellular componentplasma membrane
GO_0070062Cellular componentextracellular exosome
GO_0005911Cellular componentcell-cell junction
GO_0009986Cellular componentcell surface
GO_0070097Molecular functiondelta-catenin binding
GO_0005161Molecular functionplatelet-derived growth factor receptor binding
GO_0045296Molecular functioncadherin binding
GO_0019901Molecular functionprotein kinase binding
GO_0008013Molecular functionbeta-catenin binding
GO_0051019Molecular functionmitogen-activated protein kinase binding
GO_0045295Molecular functiongamma-catenin binding
GO_0016791Molecular functionphosphatase activity
GO_0005515Molecular functionprotein binding
GO_0004725Molecular functionprotein tyrosine phosphatase activity

IV. Literature review

[source]
Gene namePTPRJ
Protein nameProtein tyrosine phosphatase receptor type J
protein-tyrosine-phosphatase (EC 3.1.3.48)
Receptor-type tyrosine-protein phosphatase eta (Protein-tyrosine phosphatase eta) (R-PTP-eta) (EC 3.1.3.48) (Density-enhanced phosphatase 1) (DEP-1) (HPTP eta) (Protein-tyrosine phosphatase receptor type J) (R-PTP-J) (CD antigen CD148)
SynonymsDEP1
DescriptionFUNCTION: Tyrosine phosphatase which dephosphorylates or contributes to the dephosphorylation of CTNND1, FLT3, PDGFRB, MET, KDR, LYN, SRC, MAPK1, MAPK3, EGFR, TJP1, OCLN, PIK3R1 and PIK3R2 . Plays a role in cell adhesion, migration, proliferation and differentiation . Involved in vascular development (By similarity). Regulator of macrophage adhesion and spreading (By similarity). Positively affects cell-matrix adhesion (By similarity). Positive regulator of platelet activation and thrombosis. Negative regulator of cell proliferation . Negative regulator of PDGF-stimulated cell migration; through dephosphorylation of PDGFR . Positive regulator of endothelial cell survival, as well as of VEGF-induced SRC and AKT activation; through KDR dephosphorylation . Negative regulator of EGFR signaling pathway; through EGFR dephosphorylation . Enhances the barrier function of epithelial junctions during reassembly . Negatively regulates T-cell receptor (TCR) signaling . Upon T-cell TCR activation, it is up-regulated and excluded from the immunological synapses, while upon T-cell-antigen presenting cells (APC) disengagement, it is no longer excluded and can dephosphorylate PLCG1 and LAT to down-regulate prolongation of signaling . .; FUNCTION: [Isoform 2]: Activates angiogenesis and cell migration . Downregulates the expression of the endothelial adhesion molecules ICAM1 and VCAM1 . .

AccessionsE9PJ83
ENST00000534219.5
ENST00000418331.7 [Q12913-1]
ENST00000527952.1
Q12913
ENST00000698881.1
E9PPH3
A0A8V8TP51
ENST00000440289.6 [Q12913-2]