PSMD2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0042176Biological processregulation of protein catabolic process
GO_0043161Biological processproteasome-mediated ubiquitin-dependent protein catabolic process
GO_0000502Cellular componentproteasome complex
GO_0034515Cellular componentproteasome storage granule
GO_1904813Cellular componentficolin-1-rich granule lumen
GO_0070062Cellular componentextracellular exosome
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0008540Cellular componentproteasome regulatory particle, base subcomplex
GO_0005576Cellular componentextracellular region
GO_0005838Cellular componentproteasome regulatory particle
GO_0022624Cellular componentproteasome accessory complex
GO_0016020Cellular componentmembrane
GO_0034774Cellular componentsecretory granule lumen
GO_0005634Cellular componentnucleus
GO_0030234Molecular functionenzyme regulator activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePSMD2
Protein name26S proteasome non-ATPase regulatory subunit 2 (26S proteasome regulatory subunit RPN1) (26S proteasome regulatory subunit S2) (26S proteasome subunit p97) (Protein 55.11) (Tumor necrosis factor type 1 receptor-associated protein 2)
Proteasome 26S subunit ubiquitin receptor, non-ATPase 2
SynonymsTRAP2
DescriptionFUNCTION: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. .; FUNCTION: Binds to the intracellular domain of tumor necrosis factor type 1 receptor. The binding domain of TRAP1 and TRAP2 resides outside the death domain of TNFR1.

FUNCTION: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. .

AccessionsENST00000432855.1
F8WBS8
ENST00000433010.5
ENST00000445558.6
H7C1H2
ENST00000435761.5 [Q13200-2]
Q13200
ENST00000417952.5
H7C2Q3
ENST00000310118.9 [Q13200-1]
C9JPC0
ENST00000439383.5 [Q13200-3]