PSMB5 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006979Biological processresponse to oxidative stress
GO_0006508Biological processproteolysis
GO_0043161Biological processproteasome-mediated ubiquitin-dependent protein catabolic process
GO_0000502Cellular componentproteasome complex
GO_0005813Cellular componentcentrosome
GO_0070062Cellular componentextracellular exosome
GO_0005839Cellular componentproteasome core complex
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0019774Cellular componentproteasome core complex, beta-subunit complex
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0008233Molecular functionpeptidase activity
GO_0004175Molecular functionendopeptidase activity
GO_0005515Molecular functionprotein binding
GO_0004298Molecular functionthreonine-type endopeptidase activity

IV. Literature review

[source]
Gene namePSMB5
Protein nameProteasome subunit beta type-5 (EC 3.4.25.1) (Macropain epsilon chain) (Multicatalytic endopeptidase complex epsilon chain) (Proteasome chain 6) (Proteasome epsilon chain) (Proteasome subunit MB1) (Proteasome subunit X)
Proteasome 20S subunit beta 5
SynonymsMB1
X
LMPX
DescriptionFUNCTION: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Within the 20S core complex, PSMB5 displays a chymotrypsin-like activity. .

AccessionsENST00000493471.2 [P28074-2]
ENST00000555895.5
G3V3K3
ENST00000460922.2
ENST00000425762.2 [P28074-3]
ENST00000334454.10
G8JLC2
H0YJM8
P28074
ENST00000361611.11 [P28074-1]