PPP6R3 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	26 studies	45% ± 18%	Explore
astrocyte	19 studies	45% ± 19%	Explore
oligodendrocyte	15 studies	43% ± 17%	Explore
oligodendrocyte precursor cell	15 studies	45% ± 19%	Explore
microglial cell	14 studies	51% ± 16%	Explore
pericyte	12 studies	40% ± 18%	Explore
macrophage	12 studies	42% ± 18%	Explore
fibroblast	12 studies	45% ± 15%	Explore
GABAergic neuron	11 studies	46% ± 22%	Explore
glutamatergic neuron	11 studies	46% ± 24%	Explore
mast cell	11 studies	29% ± 10%	Explore
smooth muscle cell	11 studies	35% ± 12%	Explore
epithelial cell	10 studies	40% ± 20%	Explore
B cell	10 studies	30% ± 12%	Explore
adipocyte	9 studies	50% ± 11%	Explore
basal cell	9 studies	39% ± 23%	Explore
natural killer cell	8 studies	28% ± 11%	Explore
myeloid cell	8 studies	30% ± 10%	Explore
ciliated cell	8 studies	32% ± 13%	Explore
endothelial cell of lymphatic vessel	8 studies	45% ± 18%	Explore
type I pneumocyte	8 studies	38% ± 16%	Explore
CD4-positive, alpha-beta T cell	7 studies	27% ± 9%	Explore
dendritic cell	7 studies	38% ± 11%	Explore
T cell	7 studies	33% ± 13%	Explore
CD16-positive, CD56-dim natural killer cell, human	6 studies	20% ± 8%	Explore
neuron	6 studies	49% ± 21%	Explore
interneuron	6 studies	60% ± 20%	Explore
naive B cell	6 studies	16% ± 1%	Explore
CD8-positive, alpha-beta T cell	6 studies	25% ± 9%	Explore
type II pneumocyte	6 studies	39% ± 14%	Explore
CD16-negative, CD56-bright natural killer cell, human	5 studies	23% ± 9%	Explore
effector memory CD8-positive, alpha-beta T cell	5 studies	25% ± 9%	Explore
cardiac muscle cell	5 studies	52% ± 13%	Explore
mesothelial cell	5 studies	34% ± 13%	Explore
retina horizontal cell	5 studies	44% ± 18%	Explore
monocyte	5 studies	44% ± 8%	Explore
goblet cell	5 studies	35% ± 30%	Explore
club cell	5 studies	44% ± 13%	Explore
regulatory T cell	5 studies	27% ± 10%	Explore
classical monocyte	4 studies	21% ± 5%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	4 studies	25% ± 10%	Explore
granule cell	4 studies	42% ± 4%	Explore
plasma cell	4 studies	39% ± 9%	Explore
capillary endothelial cell	4 studies	37% ± 14%	Explore
endothelial cell of artery	4 studies	24% ± 8%	Explore
lymphocyte	4 studies	43% ± 21%	Explore
Mueller cell	4 studies	49% ± 14%	Explore
amacrine cell	4 studies	44% ± 12%	Explore
retinal cone cell	4 studies	39% ± 12%	Explore
retinal rod cell	4 studies	41% ± 8%	Explore
abnormal cell	4 studies	31% ± 20%	Explore
respiratory goblet cell	4 studies	46% ± 15%	Explore
CD8-positive, alpha-beta memory T cell	4 studies	19% ± 5%	Explore
hematopoietic precursor cell	3 studies	33% ± 14%	Explore
non-classical monocyte	3 studies	28% ± 7%	Explore
GABAergic interneuron	3 studies	45% ± 6%	Explore
glial cell	3 studies	33% ± 13%	Explore
progenitor cell	3 studies	38% ± 6%	Explore
endocardial cell	3 studies	33% ± 13%	Explore
mononuclear phagocyte	3 studies	31% ± 11%	Explore
mucosal invariant T cell	3 studies	28% ± 9%	Explore
vein endothelial cell	3 studies	47% ± 23%	Explore
retinal bipolar neuron	3 studies	32% ± 11%	Explore
GABAergic amacrine cell	3 studies	39% ± 12%	Explore
OFF-bipolar cell	3 studies	37% ± 15%	Explore
ON-bipolar cell	3 studies	39% ± 17%	Explore
glycinergic amacrine cell	3 studies	40% ± 6%	Explore
retinal ganglion cell	3 studies	34% ± 14%	Explore
rod bipolar cell	3 studies	38% ± 18%	Explore
endothelial cell of vascular tree	3 studies	48% ± 23%	Explore
hepatocyte	3 studies	65% ± 18%	Explore
retinal pigment epithelial cell	3 studies	49% ± 28%	Explore
ependymal cell	3 studies	53% ± 16%	Explore
alveolar macrophage	3 studies	50% ± 12%	Explore
myofibroblast cell	3 studies	45% ± 21%	Explore
gamma-delta T cell	3 studies	21% ± 7%	Explore
muscle cell	3 studies	55% ± 27%	Explore
leukocyte	3 studies	60% ± 4%	Explore
transit amplifying cell	3 studies	44% ± 34%	Explore
renal principal cell	3 studies	31% ± 14%	Explore
mural cell	3 studies	56% ± 13%	Explore
mucus secreting cell	3 studies	44% ± 13%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	17 studies	46% ± 21%	Explore
lung	7 studies	34% ± 13%	Explore
heart	5 studies	38% ± 13%	Explore
eye	5 studies	50% ± 19%	Explore
peripheral blood	3 studies	21% ± 1%	Explore
liver	3 studies	43% ± 17%	Explore
intestine	3 studies	19% ± 1%	Explore
adipose	3 studies	46% ± 14%	Explore
kidney	3 studies	33% ± 7%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
bladder	100%	6411.05	21 / 21	100%	40.56	504 / 504
breast	100%	5939.09	459 / 459	100%	54.47	1118 / 1118
esophagus	100%	5897.60	1445 / 1445	100%	58.81	183 / 183
intestine	100%	6440.42	966 / 966	100%	37.11	527 / 527
liver	100%	2919.67	226 / 226	100%	22.82	406 / 406
lung	100%	6073.72	578 / 578	100%	41.87	1155 / 1155
ovary	100%	6862.43	180 / 180	100%	32.27	430 / 430
pancreas	100%	2775.21	328 / 328	100%	34.09	178 / 178
prostate	100%	6349.48	245 / 245	100%	44.79	502 / 502
stomach	100%	4668.60	359 / 359	100%	39.81	286 / 286
thymus	100%	8683.30	653 / 653	100%	43.29	605 / 605
uterus	100%	6450.10	170 / 170	100%	38.32	459 / 459
kidney	100%	3953.46	89 / 89	100%	32.64	899 / 901
brain	100%	3273.86	2633 / 2642	100%	33.49	705 / 705
adrenal gland	100%	5784.59	258 / 258	98%	23.91	226 / 230
skin	100%	5271.62	1809 / 1809	96%	34.77	455 / 472
adipose	100%	5417.79	1204 / 1204	0%	0	0 / 0
blood vessel	100%	5386.18	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	34.30	29 / 29
muscle	100%	5697.00	803 / 803	0%	0	0 / 0
spleen	100%	6321.86	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	35.75	45 / 45
ureter	0%	0	0 / 0	100%	33.28	1 / 1
heart	99%	3784.27	853 / 861	0%	0	0 / 0
peripheral blood	94%	3749.23	874 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	81%	16.33	65 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0043666	Biological process	regulation of phosphoprotein phosphatase activity
GO_0005654	Cellular component	nucleoplasm
GO_0005829	Cellular component	cytosol
GO_0005886	Cellular component	plasma membrane
GO_0005634	Cellular component	nucleus
GO_0019888	Molecular function	protein phosphatase regulator activity
GO_0005515	Molecular function	protein binding
GO_0019903	Molecular function	protein phosphatase binding

IV. Literature review

[source]

Gene name	PPP6R3
Protein name	Serine/threonine-protein phosphatase 6 regulatory subunit 3 (SAPS domain family member 3) (Sporulation-induced transcript 4-associated protein SAPL) Protein phosphatase 6 regulatory subunit 3
Synonyms	SAPL SAPS3 C11orf23 KIAA1558 PP6R3
Description	FUNCTION: Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. May have an important role in maintaining immune self-tolerance. .
Accessions	E9PQP7 ENST00000529907.5 E9PKG4 ENST00000525421.5 H0YEV0 ENST00000524845.5 [Q5H9R7-6] H0YEN2 E9PNN8 ENST00000531244.1 ENST00000534190.5 ENST00000526593.1 E9PK08 ENST00000393800.7 [Q5H9R7-1] ENST00000527403.6 Q5H9R7 H0YDW1 ENST00000529710.5 [Q5H9R7-3] ENST00000530734.1 H0YDK9 ENST00000528635.5 H7BXH2 E9PKF6 ENST00000534534.5 ENST00000524904.5 [Q5H9R7-2] ENST00000265636.9 [Q5H9R7-4] ENST00000533127.5 ENST00000393801.7 [Q5H9R7-5] ENST00000265637.8 ENST00000529344.5 A0A1D5RMU2 E9PJD8

PPP6R3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review