PPP6C | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
regulatory T cell	16 studies	22% ± 5%	Explore
endothelial cell	15 studies	24% ± 7%	Explore
B cell	12 studies	20% ± 4%	Explore
CD4-positive, alpha-beta T cell	12 studies	20% ± 3%	Explore
CD8-positive, alpha-beta T cell	12 studies	21% ± 4%	Explore
natural killer cell	12 studies	22% ± 4%	Explore
non-classical monocyte	10 studies	23% ± 10%	Explore
CD16-positive, CD56-dim natural killer cell, human	10 studies	22% ± 5%	Explore
naive B cell	10 studies	20% ± 3%	Explore
classical monocyte	9 studies	22% ± 8%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	9 studies	20% ± 3%	Explore
plasmacytoid dendritic cell	9 studies	22% ± 7%	Explore
memory B cell	8 studies	20% ± 3%	Explore
mucosal invariant T cell	8 studies	22% ± 3%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	8 studies	19% ± 4%	Explore
gamma-delta T cell	8 studies	25% ± 9%	Explore
CD16-negative, CD56-bright natural killer cell, human	7 studies	22% ± 4%	Explore
CD8-positive, alpha-beta memory T cell	7 studies	22% ± 9%	Explore
epithelial cell	6 studies	33% ± 12%	Explore
macrophage	6 studies	20% ± 2%	Explore
CD4-positive, alpha-beta memory T cell	6 studies	21% ± 3%	Explore
effector memory CD8-positive, alpha-beta T cell	5 studies	22% ± 3%	Explore
monocyte	5 studies	19% ± 3%	Explore
effector CD8-positive, alpha-beta T cell	5 studies	21% ± 4%	Explore
astrocyte	5 studies	24% ± 5%	Explore
goblet cell	5 studies	25% ± 11%	Explore
T cell	5 studies	22% ± 3%	Explore
mature NK T cell	5 studies	19% ± 2%	Explore
plasmablast	4 studies	43% ± 20%	Explore
lymphocyte	4 studies	17% ± 1%	Explore
precursor B cell	4 studies	27% ± 5%	Explore
fibroblast	4 studies	23% ± 5%	Explore
ciliated cell	4 studies	24% ± 5%	Explore
endothelial cell of vascular tree	4 studies	18% ± 4%	Explore
endothelial cell of lymphatic vessel	4 studies	21% ± 5%	Explore
type I pneumocyte	4 studies	20% ± 3%	Explore
GABAergic neuron	4 studies	37% ± 12%	Explore
glutamatergic neuron	4 studies	47% ± 17%	Explore
effector memory CD4-positive, alpha-beta T cell	4 studies	22% ± 4%	Explore
abnormal cell	4 studies	21% ± 3%	Explore
oligodendrocyte	4 studies	23% ± 2%	Explore
conventional dendritic cell	3 studies	36% ± 14%	Explore
pro-B cell	3 studies	25% ± 2%	Explore
T follicular helper cell	3 studies	22% ± 1%	Explore
exhausted T cell	3 studies	21% ± 3%	Explore
oligodendrocyte precursor cell	3 studies	24% ± 4%	Explore
dendritic cell	3 studies	39% ± 15%	Explore
smooth muscle cell	3 studies	17% ± 1%	Explore
basal cell	3 studies	35% ± 3%	Explore
transit amplifying cell	3 studies	21% ± 7%	Explore
adipocyte	3 studies	20% ± 4%	Explore
interneuron	3 studies	35% ± 15%	Explore
neuron	3 studies	30% ± 7%	Explore
double negative thymocyte	3 studies	30% ± 5%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	11 studies	22% ± 3%	Explore
brain	6 studies	33% ± 13%	Explore
lung	5 studies	21% ± 6%	Explore
bone marrow	3 studies	17% ± 2%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
breast	100%	4597.34	459 / 459	100%	79.43	1118 / 1118
esophagus	100%	3685.82	1445 / 1445	100%	55.21	183 / 183
intestine	100%	3709.43	966 / 966	100%	51.11	527 / 527
lung	100%	3717.38	578 / 578	100%	50.95	1155 / 1155
ovary	100%	3003.16	180 / 180	100%	41.76	430 / 430
pancreas	100%	2501.29	328 / 328	100%	45.16	178 / 178
prostate	100%	3129.47	245 / 245	100%	58.90	502 / 502
stomach	100%	3060.02	359 / 359	100%	49.12	286 / 286
uterus	100%	3427.45	170 / 170	100%	54.32	459 / 459
brain	100%	3358.12	2641 / 2642	100%	66.88	705 / 705
kidney	100%	3241.34	89 / 89	100%	50.03	900 / 901
thymus	100%	4124.73	653 / 653	100%	64.65	604 / 605
bladder	100%	3144.10	21 / 21	100%	47.17	503 / 504
skin	100%	4348.17	1809 / 1809	100%	48.75	471 / 472
adrenal gland	100%	4279.10	258 / 258	100%	52.61	229 / 230
liver	100%	1719.73	226 / 226	99%	27.55	402 / 406
blood vessel	100%	4594.08	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	63.79	29 / 29
muscle	100%	7414.63	803 / 803	0%	0	0 / 0
spleen	100%	3887.58	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	59.29	45 / 45
ureter	0%	0	0 / 0	100%	28.88	1 / 1
adipose	100%	4848.18	1203 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	99%	45.52	79 / 80
peripheral blood	99%	3747.55	916 / 929	0%	0	0 / 0
heart	98%	2447.52	847 / 861	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0160049	Biological process	negative regulation of cGAS/STING signaling pathway
GO_0006470	Biological process	protein dephosphorylation
GO_0048208	Biological process	COPII vesicle coating
GO_0000082	Biological process	G1/S transition of mitotic cell cycle
GO_0045087	Biological process	innate immune response
GO_0005654	Cellular component	nucleoplasm
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0005739	Cellular component	mitochondrion
GO_0046872	Molecular function	metal ion binding
GO_0005515	Molecular function	protein binding
GO_0017018	Molecular function	myosin phosphatase activity
GO_0004722	Molecular function	protein serine/threonine phosphatase activity

IV. Literature review

[source]

Gene name	PPP6C
Protein name	Serine/threonine-protein phosphatase 6 catalytic subunit (PP6C) (EC 3.1.3.16) [Cleaved into: Serine/threonine-protein phosphatase 6 catalytic subunit, N-terminally processed] Protein phosphatase 6 catalytic subunit isoform 2 Serine/threonine-protein phosphatase (EC 3.1.3.16)
Synonyms	PPP6
Description	FUNCTION: Catalytic subunit of protein phosphatase 6 (PP6) . PP6 is a component of a signaling pathway regulating cell cycle progression in response to IL2 receptor stimulation . N-terminal domain restricts G1 to S phase progression in cancer cells, in part through control of cyclin D1 . During mitosis, regulates spindle positioning . Down-regulates MAP3K7 kinase activation of the IL1 signaling pathway by dephosphorylation of MAP3K7 . Participates also in the innate immune defense against viruses by desphosphorylating RIGI, an essential step that triggers RIGI-mediated signaling activation . Also regulates innate immunity by acting as a negative regulator of the cGAS-STING pathway: mediates dephosphorylation and inactivation of CGAS and STING1 . CGAS dephosphorylation at 'Ser-435' impairs its ability to bind GTP, thereby inactivating it . .
Accessions	O00743 ENST00000451402.5 [O00743-3] A0A024R861 A0A0S2Z482 ENST00000415905.5 [O00743-2] Q5T1S7 ENST00000373547.9 [O00743-1] ENST00000456642.1

PPP6C report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review