PNPLA2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0036155Biological processacylglycerol acyl-chain remodeling
GO_1905691Biological processlipid droplet disassembly
GO_0010898Biological processpositive regulation of triglyceride catabolic process
GO_0010891Biological processnegative regulation of sequestering of triglyceride
GO_0160077Biological processlipid droplet fusion
GO_0019433Biological processtriglyceride catabolic process
GO_0019915Biological processlipid storage
GO_0042572Biological processretinol metabolic process
GO_0006651Biological processdiacylglycerol biosynthetic process
GO_0055088Biological processlipid homeostasis
GO_0035356Biological processintracellular triglyceride homeostasis
GO_0005886Cellular componentplasma membrane
GO_0005811Cellular componentlipid droplet
GO_0016020Cellular componentmembrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0005654Cellular componentnucleoplasm
GO_0005788Cellular componentendoplasmic reticulum lumen
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0051264Molecular functionmono-olein transacylation activity
GO_0004465Molecular functionlipoprotein lipase activity
GO_0004806Molecular functiontriglyceride lipase activity
GO_0004623Molecular functionphospholipase A2 activity
GO_0016411Molecular functionacylglycerol O-acyltransferase activity
GO_0051265Molecular functiondiolein transacylation activity
GO_0050253Molecular functionretinyl-palmitate esterase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePNPLA2
Protein namePatatin-like phospholipase domain-containing protein 2 (EC 3.1.1.3)
Patatin-like phospholipase domain containing 2 (EC 3.1.1.3)
Patatin-like phospholipase domain-containing protein 2 (EC 3.1.1.3) (Adipose triglyceride lipase) (Calcium-independent phospholipase A2-zeta) (iPLA2-zeta) (EC 3.1.1.4) (Desnutrin) (Pigment epithelium-derived factor receptor) (PEDF-R) (TTS2.2) (Transport-secretion protein 2) (TTS2)
Patatin-like phospholipase domain containing 2 variant (EC 3.1.1.3)
Mutant patatin-like phospholipase domain containing 2 (EC 3.1.1.3)
SynonymsFP17548
ATGL
DescriptionFUNCTION: Catalyzes the initial step in triglyceride hydrolysis in adipocyte and non-adipocyte lipid droplets . Exhibits a strong preference for the hydrolysis of long-chain fatty acid esters at the sn-2 position of the glycerol backbone and acts coordinately with LIPE/HLS and DGAT2 within the lipolytic cascade (By similarity). Also possesses acylglycerol transacylase and phospholipase A2 activities . Transfers fatty acid from triglyceride to retinol, hydrolyzes retinylesters, and generates 1,3-diacylglycerol from triglycerides . Regulates adiposome size and may be involved in the degradation of adiposomes . May play an important role in energy homeostasis (By similarity). May play a role in the response of the organism to starvation, enhancing hydrolysis of triglycerides and providing free fatty acids to other tissues to be oxidized in situations of energy depletion (By similarity). Catalyzes the formation of an ester bond between hydroxy fatty acids and fatty acids derived from triglycerides or diglycerides to generate fatty acid esters of hydroxy fatty acids (FAHFAs) in adipocytes . .

AccessionsG4WMG7
A0A0U1WL47
A0A1W6R6W1
A0A0K0L4Y0
ENST00000336615.9 [Q96AD5-1]
A0A142EFS1
A0A0K0L4Y8
Q96AD5