PDS5B report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0008285Biological processnegative regulation of cell population proliferation
GO_0006281Biological processDNA repair
GO_0051301Biological processcell division
GO_0008283Biological processcell population proliferation
GO_0042127Biological processregulation of cell population proliferation
GO_0007064Biological processmitotic sister chromatid cohesion
GO_0000775Cellular componentchromosome, centromeric region
GO_0005694Cellular componentchromosome
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePDS5B
Protein nameSister chromatid cohesion protein PDS5 homolog B (Androgen-induced proliferation inhibitor) (Androgen-induced prostate proliferative shutoff-associated protein AS3)
PDS5 cohesin associated factor B
SynonymsAPRIN
KIAA0979
AS3
DescriptionFUNCTION: Regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Plays a role in androgen-induced proliferative arrest in prostate cells. .

AccessionsQ9NTI5
ENST00000450460.5 [Q9NTI5-2]
ENST00000315596.15 [Q9NTI5-1]
ENST00000447833.1
A9IYQ1