PCSK7 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	35 studies	31% ± 13%	Explore
T cell	28 studies	27% ± 9%	Explore
B cell	25 studies	27% ± 11%	Explore
smooth muscle cell	25 studies	23% ± 8%	Explore
CD8-positive, alpha-beta T cell	25 studies	26% ± 12%	Explore
CD4-positive, alpha-beta T cell	22 studies	27% ± 11%	Explore
regulatory T cell	21 studies	23% ± 5%	Explore
endothelial cell	17 studies	24% ± 7%	Explore
gamma-delta T cell	16 studies	24% ± 8%	Explore
CD16-positive, CD56-dim natural killer cell, human	15 studies	30% ± 11%	Explore
memory B cell	15 studies	21% ± 5%	Explore
mature NK T cell	14 studies	26% ± 10%	Explore
CD16-negative, CD56-bright natural killer cell, human	13 studies	29% ± 10%	Explore
pericyte	13 studies	23% ± 9%	Explore
mucosal invariant T cell	12 studies	21% ± 4%	Explore
CD4-positive, alpha-beta memory T cell	10 studies	22% ± 4%	Explore
CD8-positive, alpha-beta memory T cell	10 studies	25% ± 4%	Explore
effector memory CD8-positive, alpha-beta T cell	10 studies	29% ± 14%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	10 studies	24% ± 10%	Explore
fibroblast	8 studies	26% ± 15%	Explore
myofibroblast cell	8 studies	25% ± 9%	Explore
naive B cell	8 studies	22% ± 5%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	7 studies	24% ± 12%	Explore
goblet cell	7 studies	25% ± 7%	Explore
epithelial cell	7 studies	35% ± 9%	Explore
oligodendrocyte	7 studies	24% ± 7%	Explore
glutamatergic neuron	6 studies	38% ± 22%	Explore
T follicular helper cell	6 studies	23% ± 7%	Explore
oligodendrocyte precursor cell	6 studies	27% ± 9%	Explore
type I pneumocyte	5 studies	21% ± 2%	Explore
adipocyte	5 studies	21% ± 4%	Explore
effector memory CD4-positive, alpha-beta T cell	5 studies	30% ± 20%	Explore
macrophage	5 studies	22% ± 3%	Explore
GABAergic neuron	5 studies	36% ± 19%	Explore
leukocyte	4 studies	18% ± 2%	Explore
exhausted T cell	4 studies	29% ± 16%	Explore
non-classical monocyte	4 studies	34% ± 18%	Explore
microglial cell	4 studies	20% ± 3%	Explore
connective tissue cell	4 studies	20% ± 5%	Explore
lymphocyte	4 studies	38% ± 9%	Explore
effector CD8-positive, alpha-beta T cell	4 studies	18% ± 3%	Explore
innate lymphoid cell	4 studies	22% ± 3%	Explore
muscle cell	4 studies	38% ± 14%	Explore
astrocyte	4 studies	29% ± 8%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	24% ± 6%	Explore
double negative thymocyte	4 studies	28% ± 8%	Explore
endothelial cell of lymphatic vessel	3 studies	18% ± 2%	Explore
classical monocyte	3 studies	35% ± 13%	Explore
conventional dendritic cell	3 studies	32% ± 18%	Explore
amacrine cell	3 studies	31% ± 11%	Explore
retinal bipolar neuron	3 studies	25% ± 3%	Explore
monocyte	3 studies	26% ± 2%	Explore
cardiac muscle cell	3 studies	21% ± 4%	Explore
effector CD4-positive, alpha-beta T cell	3 studies	21% ± 3%	Explore
CD4-positive helper T cell	3 studies	23% ± 0%	Explore
basal cell	3 studies	33% ± 4%	Explore
endothelial cell of vascular tree	3 studies	24% ± 6%	Explore
dendritic cell	3 studies	38% ± 21%	Explore
alveolar macrophage	3 studies	22% ± 5%	Explore
transit amplifying cell	3 studies	26% ± 12%	Explore
T-helper 17 cell	3 studies	30% ± 3%	Explore
interneuron	3 studies	33% ± 20%	Explore
neuron	3 studies	33% ± 10%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	19% ± 3%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	9 studies	30% ± 14%	Explore
brain	9 studies	28% ± 16%	Explore
lung	7 studies	24% ± 6%	Explore
eye	4 studies	22% ± 6%	Explore
liver	4 studies	25% ± 7%	Explore
intestine	4 studies	21% ± 5%	Explore
uterus	3 studies	20% ± 3%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	2209.53	1444 / 1445	100%	6.23	183 / 183
intestine	100%	2786.02	966 / 966	100%	6.27	526 / 527
stomach	100%	2073.08	359 / 359	100%	6.08	285 / 286
pancreas	100%	922.75	327 / 328	98%	4.16	175 / 178
lung	100%	1774.19	576 / 578	98%	3.95	1130 / 1155
breast	100%	1618.43	459 / 459	95%	3.07	1059 / 1118
skin	100%	1520.20	1805 / 1809	94%	3.03	446 / 472
bladder	100%	1896.00	21 / 21	94%	3.63	474 / 504
ovary	99%	1061.93	179 / 180	93%	3.23	402 / 430
prostate	100%	1757.97	244 / 245	92%	2.69	460 / 502
kidney	99%	970.76	88 / 89	92%	2.81	832 / 901
thymus	100%	1416.87	651 / 653	88%	2.27	531 / 605
uterus	100%	2164.14	170 / 170	84%	2.56	386 / 459
brain	82%	549.29	2176 / 2642	98%	3.79	690 / 705
adrenal gland	100%	1110.30	257 / 258	68%	1.51	156 / 230
liver	93%	673.12	211 / 226	65%	1.32	263 / 406
adipose	100%	1697.98	1204 / 1204	0%	0	0 / 0
blood vessel	100%	3675.70	1335 / 1335	0%	0	0 / 0
spleen	100%	1758.84	241 / 241	0%	0	0 / 0
muscle	98%	712.26	783 / 803	0%	0	0 / 0
peripheral blood	96%	1626.63	894 / 929	0%	0	0 / 0
tonsil	0%	0	0 / 0	93%	2.32	42 / 45
heart	93%	830.06	799 / 861	0%	0	0 / 0
lymph node	0%	0	0 / 0	86%	4.32	25 / 29
eye	0%	0	0 / 0	85%	1.99	68 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0016486	Biological process	peptide hormone processing
GO_0016485	Biological process	protein processing
GO_0005802	Cellular component	trans-Golgi network
GO_0000139	Cellular component	Golgi membrane
GO_0008233	Molecular function	peptidase activity
GO_0005515	Molecular function	protein binding
GO_0004252	Molecular function	serine-type endopeptidase activity

IV. Literature review

[source]

Gene name	PCSK7
Protein name	Proprotein convertase subtilisin/kexin type 7 Proprotein convertase subtilisin/kexin type 7 (EC 3.4.21.-) (Lymphoma proprotein convertase) (Prohormone convertase 7) (Proprotein convertase 7) (PC7) (Proprotein convertase 8) (PC8) (hPC8) (Subtilisin/kexin-like protease PC7)
Synonyms	LPC PC8 PC7 SPC7
Description	FUNCTION: Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif. Likely functions in the constitutive secretory pathway.
Accessions	Q16549 ENST00000320934.8 E9PLM0 E9PIW7 ENST00000524507 ENST00000676339.1 ENST00000524507.6 ENST00000530269.1 ENST00000525027.1 A0A1B0GX40 ENST00000532301.5 E9PMC0

PCSK7 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review