PCBD1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
epithelial cell	17 studies	48% ± 25%	Explore
macrophage	16 studies	26% ± 12%	Explore
ciliated cell	15 studies	42% ± 20%	Explore
fibroblast	15 studies	23% ± 10%	Explore
basal cell	14 studies	33% ± 19%	Explore
smooth muscle cell	12 studies	26% ± 4%	Explore
endothelial cell of lymphatic vessel	10 studies	37% ± 14%	Explore
conventional dendritic cell	9 studies	28% ± 12%	Explore
goblet cell	9 studies	43% ± 20%	Explore
type II pneumocyte	8 studies	48% ± 22%	Explore
abnormal cell	8 studies	37% ± 21%	Explore
pericyte	8 studies	21% ± 4%	Explore
type I pneumocyte	7 studies	31% ± 19%	Explore
secretory cell	7 studies	34% ± 16%	Explore
epithelial cell of proximal tubule	7 studies	48% ± 14%	Explore
connective tissue cell	7 studies	21% ± 3%	Explore
myofibroblast cell	7 studies	20% ± 4%	Explore
kidney loop of Henle epithelial cell	6 studies	33% ± 8%	Explore
enterocyte	6 studies	29% ± 15%	Explore
progenitor cell	6 studies	49% ± 19%	Explore
endothelial cell	6 studies	30% ± 9%	Explore
club cell	5 studies	30% ± 12%	Explore
classical monocyte	5 studies	23% ± 7%	Explore
renal alpha-intercalated cell	5 studies	57% ± 4%	Explore
enteroendocrine cell	5 studies	49% ± 26%	Explore
intestinal crypt stem cell	5 studies	38% ± 13%	Explore
transit amplifying cell	5 studies	33% ± 12%	Explore
myeloid cell	5 studies	26% ± 10%	Explore
pancreatic A cell	4 studies	68% ± 17%	Explore
type B pancreatic cell	4 studies	55% ± 15%	Explore
non-classical monocyte	4 studies	23% ± 4%	Explore
kidney distal convoluted tubule epithelial cell	4 studies	55% ± 9%	Explore
mesothelial cell	4 studies	36% ± 15%	Explore
hematopoietic stem cell	4 studies	27% ± 8%	Explore
plasma cell	4 studies	25% ± 5%	Explore
neuron	4 studies	52% ± 16%	Explore
acinar cell	4 studies	39% ± 22%	Explore
dendritic cell	4 studies	42% ± 14%	Explore
hematopoietic precursor cell	3 studies	33% ± 14%	Explore
deuterosomal cell	3 studies	19% ± 4%	Explore
duct epithelial cell	3 studies	18% ± 4%	Explore
ionocyte	3 studies	30% ± 4%	Explore
pancreatic D cell	3 studies	60% ± 19%	Explore
natural killer cell	3 studies	17% ± 1%	Explore
neural crest cell	3 studies	30% ± 1%	Explore
retinal ganglion cell	3 studies	49% ± 25%	Explore
renal principal cell	3 studies	47% ± 9%	Explore
neuroendocrine cell	3 studies	52% ± 29%	Explore
retina horizontal cell	3 studies	27% ± 5%	Explore
retinal cone cell	3 studies	33% ± 10%	Explore
serous secreting cell	3 studies	25% ± 2%	Explore
Mueller cell	3 studies	32% ± 7%	Explore
intermediate monocyte	3 studies	23% ± 5%	Explore
luminal cell of prostate epithelium	3 studies	26% ± 6%	Explore
endothelial cell of vascular tree	3 studies	20% ± 2%	Explore
pancreatic ductal cell	3 studies	56% ± 11%	Explore
brush cell	3 studies	22% ± 9%	Explore
hepatocyte	3 studies	58% ± 30%	Explore
luminal hormone-sensing cell of mammary gland	3 studies	31% ± 5%	Explore
progenitor cell of mammary luminal epithelium	3 studies	31% ± 8%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	13 studies	27% ± 15%	Explore
kidney	8 studies	25% ± 7%	Explore
intestine	8 studies	26% ± 9%	Explore
pancreas	4 studies	58% ± 18%	Explore
eye	4 studies	24% ± 4%	Explore
liver	4 studies	24% ± 3%	Explore
uterus	3 studies	35% ± 19%	Explore
prostate	3 studies	22% ± 6%	Explore
brain	3 studies	16% ± 1%	Explore
breast	3 studies	21% ± 1%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	2658.85	1445 / 1445	100%	130.77	183 / 183
liver	100%	8317.01	226 / 226	100%	308.77	406 / 406
ovary	100%	2145.93	180 / 180	100%	320.09	430 / 430
pancreas	100%	3096.10	328 / 328	100%	149.67	178 / 178
stomach	100%	2823.59	359 / 359	100%	232.86	286 / 286
intestine	100%	3036.87	965 / 966	100%	242.44	527 / 527
thymus	100%	2771.18	653 / 653	100%	177.02	604 / 605
prostate	100%	2620.11	245 / 245	100%	265.73	501 / 502
kidney	100%	6035.02	89 / 89	100%	176.90	897 / 901
bladder	100%	2923.24	21 / 21	99%	194.29	501 / 504
lung	100%	2170.68	576 / 578	100%	156.98	1150 / 1155
breast	100%	2423.94	459 / 459	99%	165.20	1109 / 1118
adrenal gland	100%	4202.90	258 / 258	99%	286.96	228 / 230
uterus	100%	2066.75	170 / 170	99%	131.97	454 / 459
skin	99%	1144.31	1789 / 1809	98%	85.51	461 / 472
brain	100%	2139.06	2637 / 2642	83%	56.89	585 / 705
adipose	100%	2471.41	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	136.55	80 / 80
lymph node	0%	0	0 / 0	100%	78.67	29 / 29
spleen	100%	1095.56	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	118.60	1 / 1
blood vessel	100%	2369.99	1332 / 1335	0%	0	0 / 0
muscle	100%	1897.76	800 / 803	0%	0	0 / 0
heart	98%	3014.93	842 / 861	0%	0	0 / 0
tonsil	0%	0	0 / 0	98%	81.16	44 / 45
peripheral blood	38%	658.78	352 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0019293	Biological process	tyrosine biosynthetic process, by oxidation of phenylalanine
GO_0045893	Biological process	positive regulation of DNA-templated transcription
GO_0006729	Biological process	tetrahydrobiopterin biosynthetic process
GO_0070062	Cellular component	extracellular exosome
GO_0005654	Cellular component	nucleoplasm
GO_0005829	Cellular component	cytosol
GO_0008124	Molecular function	4-alpha-hydroxytetrahydrobiopterin dehydratase activity
GO_0003713	Molecular function	transcription coactivator activity
GO_0004505	Molecular function	phenylalanine 4-monooxygenase activity
GO_0042802	Molecular function	identical protein binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	PCBD1
Protein name	Pterin-4-alpha-carbinolamine dehydratase (PHS) (EC 4.2.1.96) (4-alpha-hydroxy-tetrahydropterin dehydratase) (Dimerization cofactor of hepatocyte nuclear factor 1-alpha) (DCoH) (Dimerization cofactor of HNF1) (Phenylalanine hydroxylase-stimulating protein) (Pterin carbinolamine dehydratase) (PCD)
Synonyms	DCOH PCBD
Description	FUNCTION: Involved in tetrahydrobiopterin biosynthesis (By similarity). Seems to both prevent the formation of 7-pterins and accelerate the formation of quinonoid-BH2. Coactivator for HNF1A-dependent transcription (By similarity). Regulates the dimerization of homeodomain protein HNF1A and enhances its transcriptional activity (By similarity). Also acts as a coactivator for HNF1B-dependent transcription . .
Accessions	ENST00000299299.4 P61457

PCBD1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review