NUP98 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	20 studies	25% ± 10%	Explore
microglial cell	10 studies	25% ± 9%	Explore
adipocyte	9 studies	23% ± 8%	Explore
fibroblast	9 studies	27% ± 12%	Explore
astrocyte	9 studies	30% ± 14%	Explore
macrophage	9 studies	28% ± 11%	Explore
mast cell	8 studies	21% ± 6%	Explore
CD4-positive, alpha-beta T cell	8 studies	18% ± 3%	Explore
CD8-positive, alpha-beta T cell	8 studies	17% ± 1%	Explore
epithelial cell	8 studies	33% ± 20%	Explore
regulatory T cell	7 studies	19% ± 3%	Explore
myeloid cell	7 studies	22% ± 4%	Explore
CD8-positive, alpha-beta memory T cell	7 studies	20% ± 3%	Explore
oligodendrocyte	7 studies	28% ± 10%	Explore
natural killer cell	7 studies	17% ± 3%	Explore
dendritic cell	6 studies	27% ± 7%	Explore
effector memory CD8-positive, alpha-beta T cell	6 studies	18% ± 2%	Explore
ciliated cell	6 studies	23% ± 7%	Explore
smooth muscle cell	6 studies	20% ± 4%	Explore
mucosal invariant T cell	5 studies	21% ± 2%	Explore
CD16-negative, CD56-bright natural killer cell, human	5 studies	18% ± 1%	Explore
endothelial cell of lymphatic vessel	5 studies	26% ± 11%	Explore
GABAergic neuron	5 studies	42% ± 18%	Explore
oligodendrocyte precursor cell	5 studies	27% ± 10%	Explore
club cell	5 studies	25% ± 8%	Explore
T cell	5 studies	20% ± 1%	Explore
type II pneumocyte	5 studies	25% ± 5%	Explore
gamma-delta T cell	5 studies	21% ± 4%	Explore
CD16-positive, CD56-dim natural killer cell, human	4 studies	18% ± 4%	Explore
naive B cell	4 studies	21% ± 3%	Explore
cardiac muscle cell	4 studies	22% ± 3%	Explore
lymphocyte	4 studies	31% ± 12%	Explore
glutamatergic neuron	4 studies	56% ± 17%	Explore
monocyte	4 studies	29% ± 2%	Explore
pericyte	4 studies	29% ± 13%	Explore
type I pneumocyte	4 studies	22% ± 6%	Explore
basal cell	4 studies	28% ± 20%	Explore
interneuron	4 studies	41% ± 23%	Explore
classical monocyte	3 studies	19% ± 2%	Explore
hematopoietic precursor cell	3 studies	32% ± 11%	Explore
memory B cell	3 studies	19% ± 2%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	3 studies	20% ± 1%	Explore
non-classical monocyte	3 studies	18% ± 2%	Explore
Mueller cell	3 studies	25% ± 5%	Explore
hepatocyte	3 studies	42% ± 28%	Explore
B cell	3 studies	18% ± 3%	Explore
abnormal cell	3 studies	25% ± 11%	Explore
hematopoietic stem cell	3 studies	18% ± 2%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	33% ± 15%	Explore
myofibroblast cell	3 studies	21% ± 7%	Explore
alveolar macrophage	3 studies	30% ± 9%	Explore
muscle cell	3 studies	30% ± 17%	Explore
goblet cell	3 studies	36% ± 27%	Explore
transit amplifying cell	3 studies	39% ± 23%	Explore
mature NK T cell	3 studies	19% ± 4%	Explore
CD4-positive, alpha-beta memory T cell	3 studies	20% ± 3%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	10 studies	32% ± 18%	Explore
lung	5 studies	21% ± 6%	Explore
liver	4 studies	25% ± 11%	Explore
adipose	4 studies	21% ± 3%	Explore
peripheral blood	3 studies	18% ± 1%	Explore
heart	3 studies	21% ± 4%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	5453.59	1445 / 1445	100%	55.20	183 / 183
intestine	100%	5640.95	966 / 966	100%	40.79	527 / 527
lung	100%	7363.08	578 / 578	100%	40.64	1155 / 1155
prostate	100%	6240.69	245 / 245	100%	41.55	502 / 502
stomach	100%	4484.64	359 / 359	100%	43.82	286 / 286
breast	100%	6913.12	459 / 459	100%	48.48	1117 / 1118
bladder	100%	6477.76	21 / 21	100%	33.23	503 / 504
uterus	100%	6627.65	170 / 170	100%	33.05	458 / 459
skin	100%	7516.39	1809 / 1809	100%	42.55	470 / 472
ovary	100%	7285.51	180 / 180	100%	29.46	428 / 430
thymus	100%	6526.23	653 / 653	100%	39.73	602 / 605
kidney	100%	3736.67	89 / 89	98%	27.09	885 / 901
pancreas	98%	2858.49	321 / 328	99%	31.22	177 / 178
liver	100%	3128.94	225 / 226	97%	19.13	394 / 406
adrenal gland	100%	4325.21	258 / 258	95%	21.85	219 / 230
brain	94%	2402.42	2489 / 2642	100%	25.09	704 / 705
adipose	100%	6725.41	1204 / 1204	0%	0	0 / 0
blood vessel	100%	5926.88	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	38.14	29 / 29
muscle	100%	6770.93	803 / 803	0%	0	0 / 0
spleen	100%	6113.44	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	38.45	45 / 45
ureter	0%	0	0 / 0	100%	16.81	1 / 1
peripheral blood	99%	7503.03	922 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	99%	31.66	79 / 80
heart	97%	3870.59	838 / 861	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0006405	Biological process	RNA export from nucleus
GO_0006999	Biological process	nuclear pore organization
GO_0051028	Biological process	mRNA transport
GO_0034398	Biological process	telomere tethering at nuclear periphery
GO_0051292	Biological process	nuclear pore complex assembly
GO_0048026	Biological process	positive regulation of mRNA splicing, via spliceosome
GO_0045893	Biological process	positive regulation of DNA-templated transcription
GO_0006508	Biological process	proteolysis
GO_0006606	Biological process	protein import into nucleus
GO_0006913	Biological process	nucleocytoplasmic transport
GO_0000973	Biological process	post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery
GO_0042405	Cellular component	nuclear inclusion body
GO_0005643	Cellular component	nuclear pore
GO_0000776	Cellular component	kinetochore
GO_0005654	Cellular component	nucleoplasm
GO_0005635	Cellular component	nuclear envelope
GO_0044615	Cellular component	nuclear pore nuclear basket
GO_0016604	Cellular component	nuclear body
GO_0005829	Cellular component	cytosol
GO_0031080	Cellular component	nuclear pore outer ring
GO_0044614	Cellular component	nuclear pore cytoplasmic filaments
GO_1990904	Cellular component	ribonucleoprotein complex
GO_0031965	Cellular component	nuclear membrane
GO_0034399	Cellular component	nuclear periphery
GO_1990841	Molecular function	promoter-specific chromatin binding
GO_0008139	Molecular function	nuclear localization sequence binding
GO_0017056	Molecular function	structural constituent of nuclear pore
GO_0003729	Molecular function	mRNA binding
GO_0008236	Molecular function	serine-type peptidase activity
GO_0140693	Molecular function	molecular condensate scaffold activity
GO_0003723	Molecular function	RNA binding
GO_0003713	Molecular function	transcription coactivator activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	NUP98
Protein name	Nuclear pore complex protein Nup98-Nup96 Nucleoporin NUP98 Nucleoporin 98 and 96 precursor NUP98/NSD1 fusion protein Nuclear pore complex protein Nup98-Nup96 (EC 3.4.21.-) [Cleaved into: Nuclear pore complex protein Nup98 (98 kDa nucleoporin) (Nucleoporin Nup98) (Nup98); Nuclear pore complex protein Nup96 (96 kDa nucleoporin) (Nucleoporin Nup96) (Nup96)]
Synonyms	fusion ADAR2 NSD1
Description	FUNCTION: Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. NUP98 and NUP96 are involved in the bidirectional transport across the NPC . May anchor NUP153 and TPR to the NPC. In cooperation with DHX9, plays a role in transcription and alternative splicing activation of a subset of genes . Involved in the localization of DHX9 in discrete intranuclear foci (GLFG-body) . .; FUNCTION: (Microbial infection) Interacts with HIV-1 capsid protein P24 and nucleocapsid protein P7 and may thereby promote the integration of the virus in the host nucleus (in vitro) . Binding affinity to HIV-1 CA-NC complexes bearing the capsid change Asn-74-Asp is reduced (in vitro) . .
Accessions	E9PNN0 A0A8V8TRD0 ENST00000700597.1 H7BYP8 ENST00000524563.1 ENST00000529379.2 A0A1D8GZ55 A0A1D8GZ56 ENST00000700605.1 A0A1D8GZ64 H7C3P6 ENST00000700601.1 ENST00000527104.6 ENST00000397007.10 [P52948-3] ENST00000700608.1 A0A8V8TPX8 ENST00000359171.8 [P52948-1] ENST00000355260.8 [P52948-2] A0A3B3ITD8 A0A8V8TPX4 ENST00000700602.1 ENST00000700598.1 ENST00000429801.5 A0A8V8TQG5 Q9HDC8 A0A8V8TR23 A0A8V8TQG1 H0YEN4 H0YDA1 H0YCR0 ENST00000700607.1 H0YCT1 ENST00000397004.9 [P52948-4] A0A8V8TR21 A0A8V8TRC7 ENST00000532475.1 H0YDF4 ENST00000700595.1 A0A8V8TPW9 ENST00000700603.1 ENST00000529063.2 ENST00000397013.2 ENST00000700600.1 ENST00000700609.1 ENST00000324932.12 [P52948-5] P52948 ENST00000533346.5 A0A8V8TQF7 ENST00000650171.1 ENST00000700606.1 [P52948-4]

NUP98 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review