NINJ1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0051260Biological processprotein homooligomerization
GO_0001525Biological processangiogenesis
GO_0012501Biological processprogrammed cell death
GO_0045766Biological processpositive regulation of angiogenesis
GO_0042692Biological processmuscle cell differentiation
GO_0070269Biological processpyroptotic inflammatory response
GO_0007155Biological processcell adhesion
GO_0034113Biological processheterotypic cell-cell adhesion
GO_0042246Biological processtissue regeneration
GO_0031640Biological processkilling of cells of another organism
GO_0034145Biological processpositive regulation of toll-like receptor 4 signaling pathway
GO_0002232Biological processleukocyte chemotaxis involved in inflammatory response
GO_0050729Biological processpositive regulation of inflammatory response
GO_0007399Biological processnervous system development
GO_0005576Cellular componentextracellular region
GO_0005886Cellular componentplasma membrane
GO_0097060Cellular componentsynaptic membrane
GO_0140912Molecular functionmembrane destabilizing activity
GO_0098631Molecular functioncell adhesion mediator activity
GO_0001530Molecular functionlipopolysaccharide binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameNINJ1
Protein nameNinjurin 1
Ninjurin-1 (hNINJ1) (Nerve injury-induced protein 1) [Cleaved into: Secreted ninjurin-1 (Soluble ninjurin-1)]
Synonyms
DescriptionFUNCTION: [Ninjurin-1]: Effector of necroptotic and pyroptotic programmed cell death that mediates plasma membrane rupture (cytolysis) . Acts downstream of Gasdermin (GSDMA, GSDMB, GSDMC, GSDMD, or GSDME) or MLKL during pyroptosis or necroptosis, respectively: oligomerizes in response to death stimuli and promotes plasma membrane rupture by introducing hydrophilic faces of 2 alpha helices into the hydrophobic membrane, leading to release intracellular molecules named damage-associated molecular patterns (DAMPs) that propagate the inflammatory response . Acts as a regulator of Toll-like receptor 4 (TLR4) signaling triggered by lipopolysaccharide (LPS) during systemic inflammation; directly binds LPS . Involved in leukocyte migration during inflammation by promoting transendothelial migration of macrophages via homotypic binding (By similarity). Promotes the migration of monocytes across the brain endothelium to central nervous system inflammatory lesions . Also acts as a homophilic transmembrane adhesion molecule involved in various processes such as axonal growth, cell chemotaxis and angiogenesis . Promotes cell adhesion by mediating homophilic interactions via its extracellular N-terminal adhesion motif (N-NAM) . Involved in the progression of the inflammatory stress by promoting cell-to-cell interactions between immune cells and endothelial cells . Plays a role in nerve regeneration by promoting maturation of Schwann cells . Acts as a regulator of angiogenesis . Promotes the formation of new vessels by mediating the interaction between capillary pericyte cells and endothelial cells (By similarity). Promotes osteoclasts development by enhancing the survival of prefusion osteoclasts (By similarity). Also involved in striated muscle growth and differentiation (By similarity). .; FUNCTION: [Secreted ninjurin-1]: Secreted form generated by cleavage, which has chemotactic activity (By similarity). Acts as an anti-inflammatory mediator by promoting monocyte recruitment, thereby ameliorating atherosclerosis . .

AccessionsQ92982
ENST00000375446.5
A0A0F6X1D7