NGDN report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0140245Biological processregulation of translation at postsynapse
GO_1903077Biological processnegative regulation of protein localization to plasma membrane
GO_0099170Biological processpostsynaptic modulation of chemical synaptic transmission
GO_0000462Biological processmaturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO_0042274Biological processribosomal small subunit biogenesis
GO_0000775Cellular componentchromosome, centromeric region
GO_0098978Cellular componentglutamatergic synapse
GO_0005730Cellular componentnucleolus
GO_0030175Cellular componentfilopodium
GO_0030424Cellular componentaxon
GO_0005739Cellular componentmitochondrion
GO_0005654Cellular componentnucleoplasm
GO_0030425Cellular componentdendrite
GO_0098794Cellular componentpostsynapse
GO_0140240Cellular componentperforant pathway to dendrate granule cell synapse
GO_0032040Cellular componentsmall-subunit processome
GO_0005515Molecular functionprotein binding
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene nameNGDN
Protein nameNeuroguidin
Neuroguidin (Centromere accumulated nuclear protein 1) (CANu1) (EIF4E-binding protein)
SynonymsC14orf120
DescriptionFUNCTION: Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Its dissociation from the complex determines the transition from state pre-A1 to state pre-A1* . Inhibits mRNA translation in a cytoplasmic polyadenylation element (CPE)-dependent manner (By similarity). .

AccessionsENST00000408901.8 [Q8NEJ9-1]
ENST00000397154.7 [Q8NEJ9-2]
ENST00000556483.5
Q8NEJ9
H0YJQ1
A0A8V8TQS3
A0A8V8TRJ3
ENST00000555128.6
H0YJ17
ENST00000703257.1
ENST00000556699.2
G3V4G1
ENST00000703256.1