NCOA3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0043697Biological processcell dedifferentiation
GO_0071392Biological processcellular response to estradiol stimulus
GO_0035624Biological processreceptor transactivation
GO_0032870Biological processcellular response to hormone stimulus
GO_0006338Biological processchromatin remodeling
GO_1902459Biological processpositive regulation of stem cell population maintenance
GO_2000035Biological processregulation of stem cell division
GO_0045618Biological processpositive regulation of keratinocyte differentiation
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0070062Cellular componentextracellular exosome
GO_0032991Cellular componentprotein-containing complex
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0046966Molecular functionnuclear thyroid hormone receptor binding
GO_0016922Molecular functionnuclear receptor binding
GO_0000993Molecular functionRNA polymerase II complex binding
GO_0004402Molecular functionhistone acetyltransferase activity
GO_0003713Molecular functiontranscription coactivator activity
GO_0046983Molecular functionprotein dimerization activity
GO_0030374Molecular functionnuclear receptor coactivator activity
GO_0005515Molecular functionprotein binding
GO_0097718Molecular functiondisordered domain specific binding

IV. Literature review

[source]
Gene nameNCOA3
Protein nameNuclear receptor coactivator
Nuclear receptor coactivator 3 (NCoA-3) (EC 2.3.1.48) (ACTR) (Amplified in breast cancer 1 protein) (AIB-1) (CBP-interacting protein) (pCIP) (Class E basic helix-loop-helix protein 42) (bHLHe42) (Receptor-associated coactivator 3) (RAC-3) (Steroid receptor coactivator protein 3) (SRC-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1)
SynonymsAIB1
BHLHE42
TRAM1
RAC3
DescriptionFUNCTION: Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Displays histone acetyltransferase activity. Also involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit.

AccessionsQ569F6
Q9Y6Q9
ENST00000371998.8 [Q9Y6Q9-1]
ENST00000372004.7 [Q9Y6Q9-5]
Q0IIN7
ENST00000371997.3 [Q9Y6Q9-3]