Tissue | GTEx Coverage  | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| breast | 100% | 6593.87 | 459 / 459 | 99% | 84.58 | 1111 / 1118 |
| brain | 100% | 5408.68 | 2642 / 2642 | 99% | 32.18 | 699 / 705 |
| prostate | 100% | 3998.77 | 245 / 245 | 99% | 81.55 | 495 / 502 |
| stomach | 100% | 3947.23 | 359 / 359 | 98% | 36.69 | 281 / 286 |
| lung | 100% | 6228.45 | 577 / 578 | 98% | 39.86 | 1136 / 1155 |
| intestine | 100% | 3773.05 | 966 / 966 | 98% | 34.28 | 517 / 527 |
| esophagus | 100% | 4110.16 | 1443 / 1445 | 98% | 43.53 | 179 / 183 |
| pancreas | 100% | 3590.65 | 328 / 328 | 97% | 35.09 | 173 / 178 |
| kidney | 100% | 7855.07 | 89 / 89 | 97% | 37.76 | 874 / 901 |
| bladder | 100% | 4052.81 | 21 / 21 | 96% | 31.69 | 482 / 504 |
| thymus | 100% | 4365.70 | 653 / 653 | 91% | 31.56 | 552 / 605 |
| uterus | 99% | 2295.36 | 169 / 170 | 91% | 28.89 | 417 / 459 |
| ovary | 97% | 1636.38 | 175 / 180 | 80% | 13.99 | 342 / 430 |
| adrenal gland | 100% | 2670.58 | 258 / 258 | 68% | 11.37 | 157 / 230 |
| liver | 100% | 2097.77 | 226 / 226 | 58% | 10.48 | 234 / 406 |
| skin | 100% | 4740.98 | 1809 / 1809 | 38% | 5.54 | 177 / 472 |
| adipose | 100% | 3258.09 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| spleen | 100% | 2220.39 | 241 / 241 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 100% | 8.31 | 1 / 1 |
| blood vessel | 100% | 2685.39 | 1331 / 1335 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 93% | 31.26 | 42 / 45 |
| heart | 83% | 1088.27 | 718 / 861 | 0% | 0 | 0 / 0 |
| muscle | 36% | 379.58 | 289 / 803 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 28% | 4.46 | 8 / 29 |
| eye | 0% | 0 | 0 / 0 | 23% | 2.57 | 18 / 80 |
| peripheral blood | 19% | 1137.61 | 178 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0007605 | Biological process | sensory perception of sound |
| GO_0006897 | Biological process | endocytosis |
| GO_0030048 | Biological process | actin filament-based movement |
| GO_0042491 | Biological process | inner ear auditory receptor cell differentiation |
| GO_0006886 | Biological process | intracellular protein transport |
| GO_0007015 | Biological process | actin filament organization |
| GO_0051046 | Biological process | regulation of secretion |
| GO_0042472 | Biological process | inner ear morphogenesis |
| GO_0008104 | Biological process | protein localization |
| GO_0009410 | Biological process | response to xenobiotic stimulus |
| GO_0030330 | Biological process | DNA damage response, signal transduction by p53 class mediator |
| GO_0001726 | Cellular component | ruffle |
| GO_0032587 | Cellular component | ruffle membrane |
| GO_0005902 | Cellular component | microvillus |
| GO_0031941 | Cellular component | filamentous actin |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0031410 | Cellular component | cytoplasmic vesicle |
| GO_0030139 | Cellular component | endocytic vesicle |
| GO_0048471 | Cellular component | perinuclear region of cytoplasm |
| GO_0016020 | Cellular component | membrane |
| GO_0070062 | Cellular component | extracellular exosome |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0005794 | Cellular component | Golgi apparatus |
| GO_0016461 | Cellular component | unconventional myosin complex |
| GO_0005884 | Cellular component | actin filament |
| GO_0030175 | Cellular component | filopodium |
| GO_0015629 | Cellular component | actin cytoskeleton |
| GO_0005829 | Cellular component | cytosol |
| GO_0005938 | Cellular component | cell cortex |
| GO_0005776 | Cellular component | autophagosome |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0045334 | Cellular component | clathrin-coated endocytic vesicle |
| GO_0005905 | Cellular component | clathrin-coated pit |
| GO_0005768 | Cellular component | endosome |
| GO_0031965 | Cellular component | nuclear membrane |
| GO_0030665 | Cellular component | clathrin-coated vesicle membrane |
| GO_0045177 | Cellular component | apical part of cell |
| GO_0005765 | Cellular component | lysosomal membrane |
| GO_0005634 | Cellular component | nucleus |
| GO_0043531 | Molecular function | ADP binding |
| GO_0060001 | Molecular function | minus-end directed microfilament motor activity |
| GO_0051015 | Molecular function | actin filament binding |
| GO_0003774 | Molecular function | cytoskeletal motor activity |
| GO_0000146 | Molecular function | microfilament motor activity |
| GO_0005524 | Molecular function | ATP binding |
| GO_0005516 | Molecular function | calmodulin binding |
| GO_0005515 | Molecular function | protein binding |
| GO_0003779 | Molecular function | actin binding |
| Gene name | MYO6 |
| Protein name | Unconventional myosin-VI (Unconventional myosin-6) Myosin VI |
| Synonyms | KIAA0389 Myo6-007 |
| Description | FUNCTION: Myosins are actin-based motor molecules with ATPase activity (By similarity). Unconventional myosins serve in intracellular movements (By similarity). Myosin 6 is a reverse-direction motor protein that moves towards the minus-end of actin filaments . Has slow rate of actin-activated ADP release due to weak ATP binding (By similarity). Functions in a variety of intracellular processes such as vesicular membrane trafficking and cell migration (By similarity). Required for the structural integrity of the Golgi apparatus via the p53-dependent pro-survival pathway . Appears to be involved in a very early step of clathrin-mediated endocytosis in polarized epithelial cells . Together with TOM1, mediates delivery of endocytic cargo to autophagosomes thereby promoting autophagosome maturation and driving fusion with lysosomes . Links TOM1 with autophagy receptors, such as TAX1BP1; CALCOCO2/NDP52 and OPTN . May act as a regulator of F-actin dynamics (By similarity). As part of the DISP complex, may regulate the association of septins with actin and thereby regulate the actin cytoskeleton . May play a role in transporting DAB2 from the plasma membrane to specific cellular targets (By similarity). May play a role in the extension and network organization of neurites (By similarity). Required for structural integrity of inner ear hair cells (By similarity). Modulates RNA polymerase II-dependent transcription . . |
| Accessions | ENST00000662603.1 A0A590UJY4 A0A1Y0BRN3 A0A590UK86 A0A590UK71 A0A590UKB0 ENST00000671923.1 ENST00000660420.1 ENST00000627432.3 ENST00000672093.1 ENST00000369977.8 [Q9UM54-1] ENST00000663400.1 A0A5F9ZI03 ENST00000664640.1 Q9UM54 A0A590UJ48 A0A0A0MRM8 A0A590UJ75 ENST00000369975.6 ENST00000662184.1 ENST00000430435.1 ENST00000653423.1 A0A590UJW9 A0A590UJ40 ENST00000369985.9 [Q9UM54-2] Q5JVM0 A0A590UK22 A0A0D9SGC1 ENST00000615563.4 [Q9UM54-2] ENST00000653917.1 ENST00000462633.3 ENST00000664209.1 |
