MYO1G report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0031589Biological processcell-substrate adhesion
GO_0006897Biological processendocytosis
GO_0030048Biological processactin filament-based movement
GO_0051649Biological processestablishment of localization in cell
GO_0006887Biological processexocytosis
GO_0007015Biological processactin filament organization
GO_0002456Biological processT cell mediated immunity
GO_0072678Biological processT cell migration
GO_0120117Biological processT cell meandering migration
GO_0071976Biological processcell gliding
GO_0038096Biological processFc-gamma receptor signaling pathway involved in phagocytosis
GO_0005902Cellular componentmicrovillus
GO_0031256Cellular componentleading edge membrane
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0070062Cellular componentextracellular exosome
GO_0005654Cellular componentnucleoplasm
GO_0030175Cellular componentfilopodium
GO_0015629Cellular componentactin cytoskeleton
GO_0001891Cellular componentphagocytic cup
GO_0005737Cellular componentcytoplasm
GO_0030027Cellular componentlamellipodium
GO_0016459Cellular componentmyosin complex
GO_0005547Molecular functionphosphatidylinositol-3,4,5-trisphosphate binding
GO_0043325Molecular functionphosphatidylinositol-3,4-bisphosphate binding
GO_0005546Molecular functionphosphatidylinositol-4,5-bisphosphate binding
GO_0051015Molecular functionactin filament binding
GO_0000146Molecular functionmicrofilament motor activity
GO_0005524Molecular functionATP binding
GO_0005516Molecular functioncalmodulin binding

IV. Literature review

[source]
Gene nameMYO1G
Protein nameUnconventional myosin-Ig [Cleaved into: Minor histocompatibility antigen HA-2 (mHag HA-2)]
Myosin IG
SynonymsHA2
DescriptionFUNCTION: Unconventional myosin required during immune response for detection of rare antigen-presenting cells by regulating T-cell migration. Unconventional myosins are actin-based motor molecules with ATPase activity and serve in intracellular movements. Acts as a regulator of T-cell migration by generating membrane tension, enforcing cell-intrinsic meandering search, thereby enhancing detection of rare antigens during lymph-node surveillance, enabling pathogen eradication. Also required in B-cells, where it regulates different membrane/cytoskeleton-dependent processes. Involved in Fc-gamma receptor (Fc-gamma-R) phagocytosis. .; FUNCTION: [Minor histocompatibility antigen HA-2]: Constitutes the minor histocompatibility antigen HA-2. More generally, minor histocompatibility antigens (mHags) refer to immunogenic peptide which, when complexed with MHC, can generate an immune response after recognition by specific T-cells. The peptides are derived from polymorphic intracellular proteins, which are cleaved by normal pathways of antigen processing. The binding of these peptides to MHC class I or class II molecules and their expression on the cell surface can stimulate T-cell responses and thereby trigger graft rejection or graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation from HLA-identical sibling donor. GVHD is a frequent complication after bone marrow transplantation (BMT), due to mismatch of minor histocompatibility antigen in HLA-matched sibling marrow transplants. HA-2 is restricted to MHC class I HLA-A*0201. .

AccessionsF8WAS7
B0I1T2
F8WEW9
A0A3B3IU30
ENST00000648014.1
ENST00000258787.12 [B0I1T2-1]
ENST00000464434.1
ENST00000495831.5