MVP report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0008283Biological processcell population proliferation
GO_0051028Biological processmRNA transport
GO_0042059Biological processnegative regulation of epidermal growth factor receptor signaling pathway
GO_0038127Biological processERBB signaling pathway
GO_0061099Biological processnegative regulation of protein tyrosine kinase activity
GO_0015031Biological processprotein transport
GO_0031953Biological processnegative regulation of protein autophosphorylation
GO_0072376Biological processprotein activation cascade
GO_0005856Cellular componentcytoskeleton
GO_0005643Cellular componentnuclear pore
GO_0005576Cellular componentextracellular region
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0016020Cellular componentmembrane
GO_0070062Cellular componentextracellular exosome
GO_0034774Cellular componentsecretory granule lumen
GO_1904813Cellular componentficolin-1-rich granule lumen
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_1990904Cellular componentribonucleoprotein complex
GO_0005634Cellular componentnucleus
GO_0019903Molecular functionprotein phosphatase binding
GO_0019901Molecular functionprotein kinase binding
GO_0042802Molecular functionidentical protein binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameMVP
Protein nameMajor vault protein
Major vault protein isoform G
Major vault protein isoform F
Major vault protein isoform H
Major vault protein (MVP) (Lung resistance-related protein)
Major vault protein isoform E
SynonymsLRP
hCG_1985644
DescriptionFUNCTION: Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates IFNG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases. .

FUNCTION: Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates IFNG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases. .

FUNCTION: Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates IFNG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases. .

FUNCTION: Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates IFNG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases. .

FUNCTION: Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates IFNG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases. .

AccessionsI3L155
ENST00000566859.5
H3BUK7
ENST00000569887.1
ENST00000629059.1
X5DP24
X5DNU0
X5D7R7
X5D7K9
ENST00000566252.1
X5DP17
X5D7S8
X5DRI7
H3BP76
ENST00000566066.5
H3BNF6
X5D2M8
H3BQE7
H3BRL2
ENST00000562463.5
ENST00000357402.10
ENST00000563915.5
H3BNF2
Q14764
ENST00000563123.1
ENST00000395353.5
H3BQK6
ENST00000565164.1
ENST00000563558.5
ENST00000570234.5
H3BUP3
H3BPZ2