MIA3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0035459Biological processvesicle cargo loading
GO_2000402Biological processnegative regulation of lymphocyte migration
GO_0090110Biological processCOPII-coated vesicle cargo loading
GO_0002042Biological processcell migration involved in sprouting angiogenesis
GO_0007029Biological processendoplasmic reticulum organization
GO_0007162Biological processnegative regulation of cell adhesion
GO_0042060Biological processwound healing
GO_0070973Biological processprotein localization to endoplasmic reticulum exit site
GO_0006887Biological processexocytosis
GO_0002687Biological processpositive regulation of leukocyte migration
GO_0042953Biological processlipoprotein transport
GO_0030336Biological processnegative regulation of cell migration
GO_0015031Biological processprotein transport
GO_1903038Biological processnegative regulation of leukocyte cell-cell adhesion
GO_0006888Biological processendoplasmic reticulum to Golgi vesicle-mediated transport
GO_0140052Biological processcellular response to oxidised low-density lipoprotein particle stimulus
GO_0009306Biological processprotein secretion
GO_0016020Cellular componentmembrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0070971Cellular componentendoplasmic reticulum exit site
GO_0005788Cellular componentendoplasmic reticulum lumen
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0038024Molecular functioncargo receptor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameMIA3
Protein nameTransport and Golgi organization protein 1 homolog (TANGO1) (C219-reactive peptide) (D320) (Melanoma inhibitory activity protein 3)
MIA SH3 domain ER export factor 3
SynonymsKIAA0268
UNQ6077/PRO20088
TANGO
DescriptionFUNCTION: Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum. This protein is required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers. It may participate in cargo loading of COL7A1 at endoplasmic reticulum exit sites by binding to COPII coat subunits Sec23/24 and guiding SH3-bound COL7A1 into a growing carrier. Does not play a role in global protein secretion and is apparently specific to COL7A1 cargo loading. However, it may participate in secretion of other proteins in cells that do not secrete COL7A1. It is also specifically required for the secretion of lipoproteins by participating in their export from the endoplasmic reticulum . Required for correct assembly of COPII coat components at endoplasmic reticulum exit sites (ERES) and for the localization of SEC16A and membrane-bound ER-resident complexes consisting of MIA2 and PREB/SEC12 to ERES . .

AccessionsQ5JRA6
ENST00000344922.10 [Q5JRA6-1]
ENST00000354906.7
A0A0A0MRH6
ENST00000340535.11 [Q5JRA6-4]