MGST2 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	42 studies	42% ± 18%	Explore
endothelial cell of lymphatic vessel	27 studies	54% ± 18%	Explore
macrophage	22 studies	29% ± 12%	Explore
basal cell	17 studies	36% ± 17%	Explore
conventional dendritic cell	17 studies	30% ± 14%	Explore
epithelial cell	16 studies	44% ± 20%	Explore
capillary endothelial cell	15 studies	37% ± 11%	Explore
plasmacytoid dendritic cell	15 studies	34% ± 13%	Explore
endothelial cell of vascular tree	14 studies	44% ± 14%	Explore
vein endothelial cell	13 studies	36% ± 8%	Explore
ciliated cell	11 studies	37% ± 19%	Explore
classical monocyte	10 studies	25% ± 10%	Explore
endothelial cell of artery	10 studies	49% ± 8%	Explore
myeloid cell	10 studies	24% ± 11%	Explore
secretory cell	9 studies	36% ± 16%	Explore
goblet cell	9 studies	34% ± 15%	Explore
pericyte	9 studies	25% ± 11%	Explore
monocyte	8 studies	23% ± 5%	Explore
dendritic cell	8 studies	42% ± 24%	Explore
microglial cell	8 studies	32% ± 10%	Explore
club cell	7 studies	30% ± 9%	Explore
epithelial cell of proximal tubule	7 studies	25% ± 7%	Explore
enterocyte	7 studies	41% ± 14%	Explore
respiratory goblet cell	6 studies	28% ± 17%	Explore
transit amplifying cell	6 studies	33% ± 9%	Explore
smooth muscle cell	6 studies	20% ± 2%	Explore
hematopoietic precursor cell	5 studies	34% ± 15%	Explore
mononuclear phagocyte	5 studies	30% ± 17%	Explore
enteroendocrine cell	5 studies	43% ± 13%	Explore
intestinal crypt stem cell	5 studies	35% ± 13%	Explore
hepatocyte	5 studies	43% ± 28%	Explore
duct epithelial cell	4 studies	21% ± 5%	Explore
glomerular endothelial cell	4 studies	57% ± 7%	Explore
progenitor cell	4 studies	49% ± 1%	Explore
fibroblast	4 studies	24% ± 6%	Explore
alveolar macrophage	4 studies	17% ± 2%	Explore
cardiac muscle cell	4 studies	18% ± 2%	Explore
endothelial cell of sinusoid	4 studies	31% ± 19%	Explore
erythroblast	4 studies	28% ± 8%	Explore
hematopoietic stem cell	4 studies	21% ± 2%	Explore
keratinocyte	4 studies	19% ± 2%	Explore
deuterosomal cell	3 studies	26% ± 4%	Explore
hillock cell	3 studies	26% ± 9%	Explore
pancreatic A cell	3 studies	29% ± 9%	Explore
type B pancreatic cell	3 studies	34% ± 3%	Explore
leukocyte	3 studies	25% ± 4%	Explore
abnormal cell	3 studies	34% ± 20%	Explore
serous secreting cell	3 studies	26% ± 7%	Explore
type I pneumocyte	3 studies	23% ± 10%	Explore
type II pneumocyte	3 studies	29% ± 14%	Explore
GABAergic neuron	3 studies	34% ± 10%	Explore
glutamatergic neuron	3 studies	33% ± 10%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	39% ± 20%	Explore
brush cell	3 studies	28% ± 8%	Explore
luminal hormone-sensing cell of mammary gland	3 studies	16% ± 0%	Explore
neuron	3 studies	33% ± 17%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	12 studies	25% ± 14%	Explore
intestine	9 studies	23% ± 9%	Explore
brain	6 studies	25% ± 10%	Explore
kidney	5 studies	21% ± 5%	Explore
liver	5 studies	31% ± 14%	Explore
prostate	4 studies	23% ± 8%	Explore
pancreas	3 studies	33% ± 6%	Explore
bone marrow	3 studies	17% ± 1%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
liver	100%	3298.26	226 / 226	100%	87.60	406 / 406
ovary	100%	776.28	180 / 180	100%	50.34	430 / 430
prostate	100%	1861.73	245 / 245	100%	91.90	502 / 502
kidney	100%	1647.10	89 / 89	100%	42.13	900 / 901
thymus	100%	1501.85	652 / 653	100%	38.30	605 / 605
pancreas	100%	1000.51	327 / 328	100%	60.83	178 / 178
stomach	100%	1243.75	359 / 359	100%	55.06	285 / 286
uterus	100%	1188.20	170 / 170	100%	55.29	457 / 459
intestine	100%	1738.17	965 / 966	99%	63.29	524 / 527
bladder	100%	1661.57	21 / 21	99%	70.59	500 / 504
adrenal gland	100%	2831.21	258 / 258	99%	55.56	228 / 230
lung	99%	1362.35	575 / 578	99%	38.35	1148 / 1155
esophagus	100%	2498.25	1444 / 1445	98%	39.13	180 / 183
breast	100%	1932.77	459 / 459	98%	38.68	1098 / 1118
skin	94%	1762.47	1692 / 1809	82%	24.17	387 / 472
brain	90%	532.82	2369 / 2642	73%	14.18	513 / 705
adipose	100%	1791.87	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	66.42	80 / 80
spleen	100%	1894.26	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	46.06	45 / 45
ureter	0%	0	0 / 0	100%	66.61	1 / 1
heart	100%	1947.46	859 / 861	0%	0	0 / 0
blood vessel	99%	1174.80	1321 / 1335	0%	0	0 / 0
muscle	97%	981.80	782 / 803	0%	0	0 / 0
lymph node	0%	0	0 / 0	97%	19.51	28 / 29
peripheral blood	73%	539.56	674 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0098869	Biological process	cellular oxidant detoxification
GO_0019370	Biological process	leukotriene biosynthetic process
GO_0006750	Biological process	glutathione biosynthetic process
GO_0010243	Biological process	response to organonitrogen compound
GO_0046466	Biological process	membrane lipid catabolic process
GO_0050729	Biological process	positive regulation of inflammatory response
GO_0006629	Biological process	lipid metabolic process
GO_0032496	Biological process	response to lipopolysaccharide
GO_0005886	Cellular component	plasma membrane
GO_0016020	Cellular component	membrane
GO_0005789	Cellular component	endoplasmic reticulum membrane
GO_0005635	Cellular component	nuclear envelope
GO_0005783	Cellular component	endoplasmic reticulum
GO_0043231	Cellular component	intracellular membrane-bounded organelle
GO_0008047	Molecular function	enzyme activator activity
GO_0004602	Molecular function	glutathione peroxidase activity
GO_0042802	Molecular function	identical protein binding
GO_0043295	Molecular function	glutathione binding
GO_0004364	Molecular function	glutathione transferase activity
GO_0005515	Molecular function	protein binding
GO_0004464	Molecular function	leukotriene-C4 synthase activity

IV. Literature review

[source]

Gene name	MGST2
Protein name	Microsomal glutathione S-transferase 2 (Microsomal GST-2) (EC 2.5.1.18) (Glutathione peroxidase MGST2) (EC 1.11.1.-) (Leukotriene C4 synthase MGST2) (EC 4.4.1.20) (Microsomal glutathione S-transferase II) (Microsomal GST-II)
Synonyms	GST2
Description	FUNCTION: Catalyzes several different glutathione-dependent reactions . Catalyzes the glutathione-dependent reduction of lipid hydroperoxides, such as 5-HPETE . Has glutathione transferase activity, toward xenobiotic electrophiles, such as 1-chloro-2, 4-dinitrobenzene (CDNB) . Catalyzes also the conjugation of leukotriene A4 with reduced glutathione to form leukotriene C4 (LTC4) . Involved in oxidative DNA damage induced by ER stress and anticancer agents by activating LTC4 biosynthetic machinery in nonimmune cells . .
Accessions	ENST00000616265.4 [Q99735-1] ENST00000265498.6 [Q99735-1] ENST00000506797.5 [Q99735-2] Q99735 ENST00000503816.1 [Q99735-1]

MGST2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review