MED28 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0051123Biological processRNA polymerase II preinitiation complex assembly
GO_0060261Biological processpositive regulation of transcription initiation by RNA polymerase II
GO_0051151Biological processnegative regulation of smooth muscle cell differentiation
GO_0032968Biological processpositive regulation of transcription elongation by RNA polymerase II
GO_0035019Biological processsomatic stem cell population maintenance
GO_0016592Cellular componentmediator complex
GO_0005654Cellular componentnucleoplasm
GO_0030864Cellular componentcortical actin cytoskeleton
GO_0070847Cellular componentcore mediator complex
GO_0016020Cellular componentmembrane
GO_0005634Cellular componentnucleus
GO_0005515Molecular functionprotein binding
GO_0003779Molecular functionactin binding

IV. Literature review

[source]
Gene nameMED28
Protein nameMediator of RNA polymerase II transcription subunit 28 (Endothelial-derived protein 1) (Mediator complex subunit 28) (Merlin and Grb2-interacting cytoskeletal protein) (Magicin) (Tumor angiogenesis marker EG-1)
Mediator of RNA polymerase II transcription subunit 28 (Mediator complex subunit 28)
SynonymsFKSG20
EG1
DescriptionFUNCTION: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. May be part of a complex containing NF2/merlin that participates in cellular signaling to the actin cytoskeleton downstream of tyrosine kinase signaling pathways. .

AccessionsENST00000503945.2
Q9H204
ENST00000237380.12
H0YAA8