MED13 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	29 studies	33% ± 15%	Explore
astrocyte	17 studies	38% ± 18%	Explore
fibroblast	16 studies	29% ± 13%	Explore
macrophage	15 studies	33% ± 14%	Explore
oligodendrocyte precursor cell	14 studies	39% ± 18%	Explore
oligodendrocyte	13 studies	38% ± 14%	Explore
microglial cell	11 studies	38% ± 11%	Explore
glutamatergic neuron	10 studies	46% ± 24%	Explore
pericyte	10 studies	30% ± 12%	Explore
smooth muscle cell	10 studies	28% ± 10%	Explore
GABAergic neuron	9 studies	46% ± 23%	Explore
adipocyte	9 studies	40% ± 10%	Explore
B cell	8 studies	26% ± 7%	Explore
T cell	8 studies	25% ± 8%	Explore
myeloid cell	8 studies	27% ± 7%	Explore
epithelial cell	8 studies	42% ± 22%	Explore
basal cell	8 studies	30% ± 19%	Explore
natural killer cell	7 studies	24% ± 6%	Explore
endothelial cell of lymphatic vessel	7 studies	33% ± 14%	Explore
type I pneumocyte	7 studies	31% ± 10%	Explore
neuron	7 studies	41% ± 24%	Explore
ciliated cell	7 studies	28% ± 11%	Explore
dendritic cell	7 studies	36% ± 13%	Explore
classical monocyte	6 studies	25% ± 6%	Explore
interneuron	6 studies	48% ± 24%	Explore
club cell	6 studies	32% ± 10%	Explore
mast cell	6 studies	22% ± 7%	Explore
type II pneumocyte	6 studies	33% ± 11%	Explore
monocyte	6 studies	32% ± 9%	Explore
non-classical monocyte	5 studies	22% ± 7%	Explore
CD4-positive, alpha-beta T cell	5 studies	22% ± 3%	Explore
effector memory CD8-positive, alpha-beta T cell	5 studies	21% ± 3%	Explore
retinal cone cell	5 studies	25% ± 9%	Explore
CD8-positive, alpha-beta T cell	5 studies	22% ± 3%	Explore
cardiac muscle cell	5 studies	34% ± 10%	Explore
lymphocyte	5 studies	33% ± 14%	Explore
retina horizontal cell	5 studies	26% ± 9%	Explore
goblet cell	5 studies	35% ± 25%	Explore
naive B cell	4 studies	17% ± 1%	Explore
CD16-negative, CD56-bright natural killer cell, human	4 studies	21% ± 3%	Explore
CD16-positive, CD56-dim natural killer cell, human	4 studies	20% ± 3%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	4 studies	19% ± 3%	Explore
granule cell	4 studies	31% ± 7%	Explore
retinal pigment epithelial cell	4 studies	35% ± 21%	Explore
endothelial cell of artery	4 studies	19% ± 4%	Explore
mesothelial cell	4 studies	29% ± 8%	Explore
vein endothelial cell	4 studies	30% ± 15%	Explore
Mueller cell	4 studies	29% ± 9%	Explore
amacrine cell	4 studies	25% ± 6%	Explore
retinal rod cell	4 studies	27% ± 6%	Explore
respiratory goblet cell	4 studies	30% ± 12%	Explore
capillary endothelial cell	4 studies	25% ± 7%	Explore
regulatory T cell	4 studies	21% ± 6%	Explore
hepatocyte	4 studies	56% ± 16%	Explore
myofibroblast cell	4 studies	29% ± 15%	Explore
GABAergic interneuron	3 studies	35% ± 1%	Explore
glial cell	3 studies	24% ± 4%	Explore
plasma cell	3 studies	34% ± 5%	Explore
squamous epithelial cell	3 studies	40% ± 21%	Explore
mononuclear phagocyte	3 studies	26% ± 11%	Explore
glycinergic amacrine cell	3 studies	29% ± 7%	Explore
rod bipolar cell	3 studies	25% ± 9%	Explore
CD8-positive, alpha-beta memory T cell	3 studies	17% ± 1%	Explore
endothelial cell of vascular tree	3 studies	32% ± 18%	Explore
abnormal cell	3 studies	37% ± 24%	Explore
connective tissue cell	3 studies	25% ± 9%	Explore
ependymal cell	3 studies	44% ± 15%	Explore
enteroendocrine cell	3 studies	23% ± 4%	Explore
alveolar macrophage	3 studies	41% ± 11%	Explore
Schwann cell	3 studies	28% ± 14%	Explore
muscle cell	3 studies	45% ± 24%	Explore
mural cell	3 studies	43% ± 12%	Explore
mucus secreting cell	3 studies	32% ± 8%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	17 studies	39% ± 20%	Explore
lung	8 studies	27% ± 10%	Explore
eye	5 studies	35% ± 17%	Explore
peripheral blood	4 studies	23% ± 3%	Explore
heart	4 studies	30% ± 6%	Explore
liver	3 studies	43% ± 20%	Explore
intestine	3 studies	19% ± 1%	Explore
adipose	3 studies	36% ± 7%	Explore
kidney	3 studies	25% ± 6%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	3666.69	1445 / 1445	100%	39.36	183 / 183
lung	100%	4844.00	578 / 578	100%	26.96	1152 / 1155
brain	100%	2513.47	2634 / 2642	100%	27.89	704 / 705
breast	100%	4226.52	459 / 459	99%	36.51	1111 / 1118
prostate	100%	3661.29	245 / 245	99%	20.65	498 / 502
thymus	100%	4294.89	653 / 653	99%	44.44	600 / 605
bladder	100%	3802.14	21 / 21	99%	22.07	499 / 504
pancreas	100%	2375.23	328 / 328	99%	20.21	176 / 178
uterus	100%	4359.54	170 / 170	98%	19.85	451 / 459
stomach	100%	2926.69	359 / 359	98%	27.19	281 / 286
intestine	100%	3838.45	966 / 966	98%	22.80	515 / 527
ovary	100%	4233.29	180 / 180	95%	13.39	407 / 430
kidney	100%	2671.65	89 / 89	94%	19.50	850 / 901
liver	100%	2455.09	226 / 226	92%	13.49	372 / 406
adrenal gland	100%	3512.43	258 / 258	91%	11.72	209 / 230
skin	100%	4956.09	1809 / 1809	90%	19.36	423 / 472
adipose	100%	4536.60	1204 / 1204	0%	0	0 / 0
blood vessel	100%	4390.50	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	14.77	29 / 29
muscle	100%	5365.50	803 / 803	0%	0	0 / 0
spleen	100%	3155.06	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	21.62	45 / 45
ureter	0%	0	0 / 0	100%	6.79	1 / 1
heart	98%	2215.29	842 / 861	0%	0	0 / 0
peripheral blood	92%	2740.61	856 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	60%	6.58	48 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0070328	Biological process	triglyceride homeostasis
GO_0042632	Biological process	cholesterol homeostasis
GO_0060261	Biological process	positive regulation of transcription initiation by RNA polymerase II
GO_0045893	Biological process	positive regulation of DNA-templated transcription
GO_0045944	Biological process	positive regulation of transcription by RNA polymerase II
GO_0016592	Cellular component	mediator complex
GO_0005654	Cellular component	nucleoplasm
GO_1990508	Cellular component	CKM complex
GO_0016020	Cellular component	membrane
GO_0005634	Cellular component	nucleus
GO_0046966	Molecular function	nuclear thyroid hormone receptor binding
GO_0003713	Molecular function	transcription coactivator activity
GO_0042809	Molecular function	nuclear vitamin D receptor binding
GO_0030374	Molecular function	nuclear receptor coactivator activity
GO_0003712	Molecular function	transcription coregulator activity

IV. Literature review

[source]

Gene name	MED13
Protein name	Mediator of RNA polymerase II transcription subunit 13 (Activator-recruited cofactor 250 kDa component) (ARC250) (Mediator complex subunit 13) (Thyroid hormone receptor-associated protein 1) (Thyroid hormone receptor-associated protein complex 240 kDa component) (Trap240) (Vitamin D3 receptor-interacting protein complex component DRIP250) (DRIP250) Mediator complex subunit 13
Synonyms	TRAP240 ARC250 THRAP1 KIAA0593
Description	FUNCTION: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. .
Accessions	ENST00000397786.7 ENST00000583958.1 J3QRB7 Q9UHV7

MED13 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review