MCUB | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
CD4-positive, alpha-beta T cell	30 studies	35% ± 12%	Explore
B cell	23 studies	28% ± 8%	Explore
CD8-positive, alpha-beta T cell	23 studies	30% ± 12%	Explore
T cell	19 studies	30% ± 10%	Explore
regulatory T cell	18 studies	31% ± 11%	Explore
classical monocyte	18 studies	27% ± 10%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	17 studies	37% ± 11%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	14 studies	39% ± 13%	Explore
macrophage	14 studies	22% ± 4%	Explore
naive B cell	13 studies	24% ± 5%	Explore
memory B cell	12 studies	25% ± 7%	Explore
monocyte	12 studies	23% ± 5%	Explore
CD16-negative, CD56-bright natural killer cell, human	11 studies	27% ± 10%	Explore
natural killer cell	11 studies	28% ± 9%	Explore
non-classical monocyte	10 studies	28% ± 12%	Explore
CD4-positive, alpha-beta memory T cell	9 studies	39% ± 10%	Explore
mucosal invariant T cell	9 studies	25% ± 6%	Explore
conventional dendritic cell	8 studies	30% ± 16%	Explore
gamma-delta T cell	8 studies	29% ± 9%	Explore
dendritic cell	8 studies	29% ± 15%	Explore
plasmacytoid dendritic cell	8 studies	26% ± 7%	Explore
CD8-positive, alpha-beta memory T cell	8 studies	36% ± 16%	Explore
effector memory CD8-positive, alpha-beta T cell	7 studies	31% ± 12%	Explore
myeloid cell	7 studies	23% ± 7%	Explore
mature NK T cell	6 studies	31% ± 10%	Explore
fibroblast	6 studies	20% ± 7%	Explore
T follicular helper cell	6 studies	37% ± 11%	Explore
effector CD8-positive, alpha-beta T cell	5 studies	30% ± 3%	Explore
endothelial cell	5 studies	22% ± 5%	Explore
double negative thymocyte	5 studies	37% ± 14%	Explore
endothelial cell of lymphatic vessel	5 studies	20% ± 2%	Explore
effector memory CD4-positive, alpha-beta T cell	5 studies	43% ± 13%	Explore
central memory CD8-positive, alpha-beta T cell	4 studies	23% ± 3%	Explore
plasmablast	4 studies	40% ± 16%	Explore
CD16-positive, CD56-dim natural killer cell, human	4 studies	20% ± 6%	Explore
lymphocyte	4 studies	30% ± 6%	Explore
precursor B cell	4 studies	33% ± 6%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	35% ± 6%	Explore
vein endothelial cell	4 studies	24% ± 14%	Explore
CD4-positive helper T cell	3 studies	23% ± 4%	Explore
plasma cell	3 studies	24% ± 10%	Explore
leukocyte	3 studies	30% ± 6%	Explore
exhausted T cell	3 studies	41% ± 7%	Explore
hematopoietic precursor cell	3 studies	24% ± 7%	Explore
pro-B cell	3 studies	29% ± 4%	Explore
epithelial cell	3 studies	21% ± 4%	Explore
immature B cell	3 studies	33% ± 7%	Explore
retinal bipolar neuron	3 studies	21% ± 1%	Explore
mononuclear phagocyte	3 studies	26% ± 2%	Explore
germinal center B cell	3 studies	26% ± 1%	Explore
innate lymphoid cell	3 studies	27% ± 7%	Explore
GABAergic neuron	3 studies	35% ± 5%	Explore
abnormal cell	3 studies	27% ± 9%	Explore
alveolar macrophage	3 studies	24% ± 6%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	3 studies	24% ± 3%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	33% ± 16%	Explore
interneuron	3 studies	23% ± 3%	Explore
erythrocyte	3 studies	20% ± 5%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	17 studies	29% ± 8%	Explore
bone marrow	3 studies	20% ± 6%	Explore
lung	3 studies	20% ± 4%	Explore
adipose	3 studies	19% ± 3%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
breast	100%	939.03	458 / 459	99%	23.03	1108 / 1118
lung	100%	717.81	577 / 578	98%	18.78	1135 / 1155
esophagus	100%	652.77	1441 / 1445	98%	16.52	179 / 183
uterus	100%	973.11	170 / 170	96%	28.86	441 / 459
intestine	99%	623.63	961 / 966	96%	15.02	504 / 527
ovary	99%	595.47	179 / 180	95%	19.51	407 / 430
bladder	95%	693.00	20 / 21	90%	17.85	456 / 504
thymus	98%	460.22	642 / 653	86%	17.88	523 / 605
skin	100%	846.55	1809 / 1809	74%	10.36	347 / 472
stomach	74%	291.91	266 / 359	93%	13.47	267 / 286
kidney	73%	272.98	65 / 89	80%	9.85	722 / 901
prostate	95%	421.58	233 / 245	46%	2.97	230 / 502
pancreas	31%	68.73	103 / 328	97%	20.03	173 / 178
adrenal gland	64%	158.05	164 / 258	53%	5.90	123 / 230
brain	55%	181.70	1461 / 2642	61%	16.27	431 / 705
adipose	100%	1285.76	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	41.52	29 / 29
spleen	100%	1187.37	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	28.85	45 / 45
ureter	0%	0	0 / 0	100%	5.94	1 / 1
peripheral blood	99%	1324.16	916 / 929	0%	0	0 / 0
blood vessel	97%	525.51	1300 / 1335	0%	0	0 / 0
heart	85%	582.01	736 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	50%	5.08	40 / 80
liver	16%	42.04	36 / 226	31%	3.52	124 / 406
muscle	28%	62.01	227 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0110099	Biological process	negative regulation of calcium import into the mitochondrion
GO_0043030	Biological process	regulation of macrophage activation
GO_0043403	Biological process	skeletal muscle tissue regeneration
GO_1902726	Biological process	positive regulation of skeletal muscle satellite cell differentiation
GO_0006851	Biological process	mitochondrial calcium ion transmembrane transport
GO_0036444	Biological process	calcium import into the mitochondrion
GO_0051560	Biological process	mitochondrial calcium ion homeostasis
GO_0043231	Cellular component	intracellular membrane-bounded organelle
GO_0005654	Cellular component	nucleoplasm
GO_0034704	Cellular component	calcium channel complex
GO_1990246	Cellular component	uniplex complex
GO_0016020	Cellular component	membrane
GO_0005743	Cellular component	mitochondrial inner membrane
GO_0005739	Cellular component	mitochondrion
GO_0005216	Molecular function	monoatomic ion channel activity
GO_0019855	Molecular function	calcium channel inhibitor activity

IV. Literature review

[source]

Gene name	MCUB
Protein name	Calcium uniporter regulatory subunit MCUb, mitochondrial (MCUb) (Coiled-coil domain-containing protein 109B)
Synonyms	CCDC109B
Description	FUNCTION: Negatively regulates the activity of MCU, the mitochondrial inner membrane calcium uniporter, and thereby modulates calcium uptake into the mitochondrion. Does not form functional calcium channels by itself. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways. .
Accessions	ENST00000394650.7 Q9NWR8

MCUB report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review