LRPPRC report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0051028Biological processmRNA transport
GO_0047497Biological processmitochondrion transport along microtubule
GO_0070129Biological processregulation of mitochondrial translation
GO_0000957Biological processmitochondrial RNA catabolic process
GO_0006914Biological processautophagy
GO_0000961Biological processnegative regulation of mitochondrial RNA catabolic process
GO_0005856Cellular componentcytoskeleton
GO_0005874Cellular componentmicrotubule
GO_0042645Cellular componentmitochondrial nucleoid
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0016020Cellular componentmembrane
GO_0005739Cellular componentmitochondrion
GO_0005654Cellular componentnucleoplasm
GO_0005637Cellular componentnuclear inner membrane
GO_0005640Cellular componentnuclear outer membrane
GO_0005759Cellular componentmitochondrial matrix
GO_0000794Cellular componentcondensed nuclear chromosome
GO_1990904Cellular componentribonucleoprotein complex
GO_0005634Cellular componentnucleus
GO_0048487Molecular functionbeta-tubulin binding
GO_0003697Molecular functionsingle-stranded DNA binding
GO_0051015Molecular functionactin filament binding
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0008017Molecular functionmicrotubule binding
GO_0003723Molecular functionRNA binding
GO_0003730Molecular functionmRNA 3'-UTR binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameLRPPRC
Protein nameLeucine rich pentatricopeptide repeat containing
Leucine-rich PPR motif-containing protein, mitochondrial (130 kDa leucine-rich protein) (LRP 130) (GP130)
Leucine-rich PPR-motif containing (Mitochondrial leucine-rich PPR motif-containing protein)
SynonymsLRP130
hCG_16810
DescriptionFUNCTION: May play a role in RNA metabolism in both nuclei and mitochondria. In the nucleus binds to HNRPA1-associated poly(A) mRNAs and is part of nmRNP complexes at late stages of mRNA maturation which are possibly associated with nuclear mRNA export. Positively modulates nuclear export of mRNAs containing the EIF4E sensitivity element (4ESE) by binding simultaneously to both EIF4E and the 4ESE and acting as a platform for assembly for the RNA export complex . Also binds to exportin XPO1/CRM1 to engage the nuclear pore and traffic the bound mRNAs to the cytoplasm . May bind mature mRNA in the nucleus outer membrane. In mitochondria binds to poly(A) mRNA. Plays a role in translation or stability of mitochondrially encoded cytochrome c oxidase (COX) subunits. May be involved in transcription regulation. Cooperates with PPARGC1A to regulate certain mitochondrially encoded genes and gluconeogenic genes and may regulate docking of PPARGC1A to transcription factors. Seems to be involved in the transcription regulation of the multidrug-related genes MDR1 and MVP. Part of a nuclear factor that binds to the invMED1 element of MDR1 and MVP gene promoters. Binds single-stranded DNA (By similarity). .

AccessionsA0A804HJD8
ENST00000682612.1
ENST00000419884.6
ENST00000684290.1
ENST00000682607.1
ENST00000684619.1
ENST00000684482.1
H7C3W8
ENST00000683220.1
A0A804HJA1
ENST00000683528.1
ENST00000683989.1
A0A804HI40
ENST00000683934.1
ENST00000409659.6
A0A804HI14
ENST00000409946.6
ENST00000683590.1
C9JCA9
A0A804HIV5
ENST00000683125.1
A0A804HL40
A0A804HK30
A0A804HKX6
A0A804HIQ7
A0A804HI44
ENST00000682308.1
ENST00000684397.1
ENST00000682885.1
ENST00000682546.1
E5KNY5
ENST00000683623.1
A0A804HKR3
A0A804HKJ0
ENST00000684383.1
A0A804HHY9
A0A804HKR5
A0A804HLJ6
A0A804HLK8
ENST00000682295.1
A0A804HKK7
A0A804HIN4
ENST00000682585.1
A0A804HKX0
A0A804HI23
A0A804HJZ1
A0A804HJI0
ENST00000683796.1
A0A804HJG8
A0A0C4DG06
ENST00000683236.1
ENST00000260665.12
P42704
A0A804HIG4
ENST00000683002.1
ENST00000683346.1
A0A804HKI2
A0A804HLL8
ENST00000683994.1
A0A804HK02
ENST00000682696.1
B8ZZ38
ENST00000682303.1
ENST00000683833.1
ENST00000682480.1
ENST00000682104.1
A0A804HJH8
ENST00000684306.1
A0A804HLG8
ENST00000683213.1
ENST00000447246.2
ENST00000682779.1