Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 18 studies | 27% ± 13% | |
glutamatergic neuron | 11 studies | 40% ± 26% | |
astrocyte | 11 studies | 31% ± 14% | |
oligodendrocyte | 11 studies | 31% ± 12% | |
oligodendrocyte precursor cell | 9 studies | 29% ± 14% | |
epithelial cell | 9 studies | 38% ± 16% | |
fibroblast | 9 studies | 23% ± 8% | |
macrophage | 8 studies | 28% ± 9% | |
microglial cell | 8 studies | 26% ± 9% | |
adipocyte | 8 studies | 27% ± 8% | |
GABAergic neuron | 8 studies | 44% ± 22% | |
B cell | 7 studies | 18% ± 3% | |
neuron | 7 studies | 35% ± 18% | |
basal cell | 7 studies | 29% ± 18% | |
interneuron | 6 studies | 45% ± 22% | |
retinal ganglion cell | 6 studies | 36% ± 16% | |
amacrine cell | 6 studies | 22% ± 7% | |
retina horizontal cell | 6 studies | 26% ± 10% | |
naive B cell | 5 studies | 20% ± 2% | |
myeloid cell | 5 studies | 20% ± 2% | |
ciliated cell | 5 studies | 23% ± 8% | |
pericyte | 5 studies | 24% ± 11% | |
smooth muscle cell | 5 studies | 19% ± 2% | |
natural killer cell | 5 studies | 20% ± 7% | |
CD8-positive, alpha-beta T cell | 5 studies | 18% ± 3% | |
hematopoietic precursor cell | 4 studies | 27% ± 7% | |
abnormal cell | 4 studies | 30% ± 19% | |
granule cell | 4 studies | 26% ± 7% | |
erythroblast | 4 studies | 29% ± 4% | |
retinal bipolar neuron | 4 studies | 19% ± 1% | |
retinal pigment epithelial cell | 4 studies | 29% ± 16% | |
cardiac muscle cell | 4 studies | 18% ± 2% | |
OFF-bipolar cell | 4 studies | 21% ± 6% | |
ON-bipolar cell | 4 studies | 22% ± 9% | |
retinal rod cell | 4 studies | 23% ± 3% | |
CD4-positive, alpha-beta T cell | 4 studies | 20% ± 5% | |
dendritic cell | 4 studies | 27% ± 11% | |
goblet cell | 4 studies | 30% ± 19% | |
T cell | 4 studies | 17% ± 1% | |
endothelial cell of lymphatic vessel | 4 studies | 27% ± 8% | |
transit amplifying cell | 4 studies | 37% ± 26% | |
naive thymus-derived CD8-positive, alpha-beta T cell | 3 studies | 17% ± 1% | |
GABAergic interneuron | 3 studies | 27% ± 4% | |
glial cell | 3 studies | 24% ± 6% | |
progenitor cell | 3 studies | 24% ± 6% | |
precursor B cell | 3 studies | 21% ± 2% | |
mesothelial cell | 3 studies | 20% ± 4% | |
lymphocyte | 3 studies | 23% ± 8% | |
GABAergic amacrine cell | 3 studies | 29% ± 11% | |
glycinergic amacrine cell | 3 studies | 21% ± 4% | |
rod bipolar cell | 3 studies | 28% ± 8% | |
hepatocyte | 3 studies | 39% ± 27% | |
type I pneumocyte | 3 studies | 21% ± 6% | |
type II pneumocyte | 3 studies | 23% ± 6% | |
megakaryocyte-erythroid progenitor cell | 3 studies | 35% ± 11% | |
enteroendocrine cell | 3 studies | 20% ± 5% | |
intestinal crypt stem cell | 3 studies | 30% ± 10% | |
club cell | 3 studies | 25% ± 7% | |
monocyte | 3 studies | 17% ± 2% | |
muscle cell | 3 studies | 28% ± 15% | |
mast cell | 3 studies | 17% ± 2% | |
plasmacytoid dendritic cell | 3 studies | 21% ± 4% | |
regulatory T cell | 3 studies | 19% ± 4% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
breast | 100% | 6796.93 | 459 / 459 | 100% | 79.82 | 1118 / 1118 |
esophagus | 100% | 6168.50 | 1445 / 1445 | 100% | 79.75 | 183 / 183 |
ovary | 100% | 7305.32 | 180 / 180 | 100% | 53.30 | 430 / 430 |
stomach | 100% | 6098.23 | 359 / 359 | 100% | 74.86 | 286 / 286 |
intestine | 100% | 7992.03 | 966 / 966 | 100% | 79.77 | 526 / 527 |
uterus | 100% | 7071.24 | 170 / 170 | 100% | 52.90 | 458 / 459 |
lung | 100% | 5108.27 | 576 / 578 | 100% | 60.99 | 1155 / 1155 |
bladder | 100% | 6659.05 | 21 / 21 | 100% | 59.55 | 502 / 504 |
brain | 99% | 6282.28 | 2621 / 2642 | 100% | 50.87 | 705 / 705 |
prostate | 100% | 4858.62 | 245 / 245 | 99% | 52.81 | 498 / 502 |
thymus | 100% | 5201.52 | 653 / 653 | 99% | 39.32 | 600 / 605 |
pancreas | 99% | 4749.54 | 326 / 328 | 99% | 38.35 | 177 / 178 |
liver | 100% | 4363.77 | 225 / 226 | 99% | 38.38 | 402 / 406 |
kidney | 100% | 6476.18 | 89 / 89 | 98% | 51.00 | 885 / 901 |
skin | 100% | 7872.27 | 1809 / 1809 | 97% | 63.92 | 456 / 472 |
adrenal gland | 100% | 8327.49 | 258 / 258 | 94% | 44.47 | 217 / 230 |
adipose | 100% | 6629.07 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 5876.85 | 1335 / 1335 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 100% | 54.28 | 29 / 29 |
muscle | 100% | 13514.46 | 803 / 803 | 0% | 0 | 0 / 0 |
spleen | 100% | 5081.76 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 45.89 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 16.76 | 1 / 1 |
eye | 0% | 0 | 0 / 0 | 95% | 45.26 | 76 / 80 |
heart | 95% | 6539.75 | 816 / 861 | 0% | 0 | 0 / 0 |
peripheral blood | 42% | 4732.88 | 389 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0051028 | Biological process | mRNA transport |
GO_0047497 | Biological process | mitochondrion transport along microtubule |
GO_0070129 | Biological process | regulation of mitochondrial translation |
GO_0000957 | Biological process | mitochondrial RNA catabolic process |
GO_0006914 | Biological process | autophagy |
GO_0000961 | Biological process | negative regulation of mitochondrial RNA catabolic process |
GO_0005856 | Cellular component | cytoskeleton |
GO_0005874 | Cellular component | microtubule |
GO_0042645 | Cellular component | mitochondrial nucleoid |
GO_0048471 | Cellular component | perinuclear region of cytoplasm |
GO_0016020 | Cellular component | membrane |
GO_0005739 | Cellular component | mitochondrion |
GO_0005654 | Cellular component | nucleoplasm |
GO_0005637 | Cellular component | nuclear inner membrane |
GO_0005640 | Cellular component | nuclear outer membrane |
GO_0005759 | Cellular component | mitochondrial matrix |
GO_0000794 | Cellular component | condensed nuclear chromosome |
GO_1990904 | Cellular component | ribonucleoprotein complex |
GO_0005634 | Cellular component | nucleus |
GO_0048487 | Molecular function | beta-tubulin binding |
GO_0003697 | Molecular function | single-stranded DNA binding |
GO_0051015 | Molecular function | actin filament binding |
GO_0031625 | Molecular function | ubiquitin protein ligase binding |
GO_0008017 | Molecular function | microtubule binding |
GO_0003723 | Molecular function | RNA binding |
GO_0003730 | Molecular function | mRNA 3'-UTR binding |
GO_0005515 | Molecular function | protein binding |
Gene name | LRPPRC |
Protein name | Leucine rich pentatricopeptide repeat containing Leucine-rich PPR motif-containing protein, mitochondrial (130 kDa leucine-rich protein) (LRP 130) (GP130) Leucine-rich PPR-motif containing (Mitochondrial leucine-rich PPR motif-containing protein) |
Synonyms | LRP130 hCG_16810 |
Description | FUNCTION: May play a role in RNA metabolism in both nuclei and mitochondria. In the nucleus binds to HNRPA1-associated poly(A) mRNAs and is part of nmRNP complexes at late stages of mRNA maturation which are possibly associated with nuclear mRNA export. Positively modulates nuclear export of mRNAs containing the EIF4E sensitivity element (4ESE) by binding simultaneously to both EIF4E and the 4ESE and acting as a platform for assembly for the RNA export complex . Also binds to exportin XPO1/CRM1 to engage the nuclear pore and traffic the bound mRNAs to the cytoplasm . May bind mature mRNA in the nucleus outer membrane. In mitochondria binds to poly(A) mRNA. Plays a role in translation or stability of mitochondrially encoded cytochrome c oxidase (COX) subunits. May be involved in transcription regulation. Cooperates with PPARGC1A to regulate certain mitochondrially encoded genes and gluconeogenic genes and may regulate docking of PPARGC1A to transcription factors. Seems to be involved in the transcription regulation of the multidrug-related genes MDR1 and MVP. Part of a nuclear factor that binds to the invMED1 element of MDR1 and MVP gene promoters. Binds single-stranded DNA (By similarity). . |
Accessions | A0A804HJD8 ENST00000682612.1 ENST00000419884.6 ENST00000684290.1 ENST00000682607.1 ENST00000684619.1 ENST00000684482.1 H7C3W8 ENST00000683220.1 A0A804HJA1 ENST00000683528.1 ENST00000683989.1 A0A804HI40 ENST00000683934.1 ENST00000409659.6 A0A804HI14 ENST00000409946.6 ENST00000683590.1 C9JCA9 A0A804HIV5 ENST00000683125.1 A0A804HL40 A0A804HK30 A0A804HKX6 A0A804HIQ7 A0A804HI44 ENST00000682308.1 ENST00000684397.1 ENST00000682885.1 ENST00000682546.1 E5KNY5 ENST00000683623.1 A0A804HKR3 A0A804HKJ0 ENST00000684383.1 A0A804HHY9 A0A804HKR5 A0A804HLJ6 A0A804HLK8 ENST00000682295.1 A0A804HKK7 A0A804HIN4 ENST00000682585.1 A0A804HKX0 A0A804HI23 A0A804HJZ1 A0A804HJI0 ENST00000683796.1 A0A804HJG8 A0A0C4DG06 ENST00000683236.1 ENST00000260665.12 P42704 A0A804HIG4 ENST00000683002.1 ENST00000683346.1 A0A804HKI2 A0A804HLL8 ENST00000683994.1 A0A804HK02 ENST00000682696.1 B8ZZ38 ENST00000682303.1 ENST00000683833.1 ENST00000682480.1 ENST00000682104.1 A0A804HJH8 ENST00000684306.1 A0A804HLG8 ENST00000683213.1 ENST00000447246.2 ENST00000682779.1 |