KDM6A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0010468Biological processregulation of gene expression
GO_0006338Biological processchromatin remodeling
GO_0007507Biological processheart development
GO_0035097Cellular componenthistone methyltransferase complex
GO_0005654Cellular componentnucleoplasm
GO_0044666Cellular componentMLL3/4 complex
GO_0005634Cellular componentnucleus
GO_0031490Molecular functionchromatin DNA binding
GO_0032452Molecular functionhistone demethylase activity
GO_0071558Molecular functionhistone H3K27me2/H3K27me3 demethylase activity
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0005515Molecular functionprotein binding
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameKDM6A
Protein name[histone H3]-trimethyl-L-lysine(27) demethylase (EC 1.14.11.68)
Lysine-specific demethylase 6A (EC 1.14.11.68) (Histone demethylase UTX) (Ubiquitously-transcribed TPR protein on the X chromosome) (Ubiquitously-transcribed X chromosome tetratricopeptide repeat protein) ([histone H3]-trimethyl-L-lysine(27) demethylase 6A)
Lysine demethylase 6A
SynonymsUTX
DescriptionFUNCTION: Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code . Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-27' . Plays a central role in regulation of posterior development, by regulating HOX gene expression . Demethylation of 'Lys-27' of histone H3 is concomitant with methylation of 'Lys-4' of histone H3, and regulates the recruitment of the PRC1 complex and monoubiquitination of histone H2A . Plays a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression (By similarity). .

AccessionsENST00000675577.1
ENST00000674659.1
ENST00000536777.6
ENST00000611820.5
ENST00000431196.3
F5H6S1
A0A6Q8PHJ0
ENST00000676085.1
ENST00000674586.1
ENST00000674564.1
A0A6Q8PFK0
H0Y6V5
O15550
A0A6Q8PFD0
F8W8R6
A0A087WUN6
ENST00000674541.1
A0A6Q8PG32
ENST00000676062.1
A0A6Q8PHB6
A0A804HIZ7
ENST00000674867.1
A0A6Q8PG92
ENST00000683425.1
ENST00000683021.1
ENST00000684352.1
A0A6Q8PGN0
A0A6Q8PGG6
ENST00000675514.1
ENST00000621147.5
ENST00000377967.9
A0A804HJA2
ENST00000676133.1
A0A804HLJ3
F5H5V6
ENST00000543216.6
ENST00000676343.1
ENST00000682908.1
ENST00000382899.9
A0A6Q8PH94
A0A087X0R0