Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 21 studies | 39% ± 15% | |
astrocyte | 17 studies | 36% ± 18% | |
oligodendrocyte | 14 studies | 50% ± 18% | |
microglial cell | 12 studies | 44% ± 13% | |
fibroblast | 12 studies | 33% ± 14% | |
macrophage | 11 studies | 38% ± 15% | |
glutamatergic neuron | 10 studies | 40% ± 25% | |
oligodendrocyte precursor cell | 10 studies | 35% ± 16% | |
GABAergic neuron | 8 studies | 42% ± 20% | |
adipocyte | 8 studies | 31% ± 9% | |
epithelial cell | 7 studies | 38% ± 21% | |
dendritic cell | 7 studies | 32% ± 10% | |
pericyte | 7 studies | 31% ± 13% | |
smooth muscle cell | 7 studies | 29% ± 6% | |
interneuron | 6 studies | 47% ± 22% | |
myeloid cell | 6 studies | 27% ± 8% | |
mast cell | 6 studies | 28% ± 7% | |
T cell | 6 studies | 29% ± 7% | |
endothelial cell of lymphatic vessel | 6 studies | 41% ± 16% | |
neuron | 5 studies | 47% ± 26% | |
B cell | 5 studies | 32% ± 9% | |
CD4-positive, alpha-beta T cell | 5 studies | 24% ± 7% | |
cardiac muscle cell | 5 studies | 33% ± 8% | |
ciliated cell | 5 studies | 28% ± 12% | |
monocyte | 5 studies | 37% ± 8% | |
basal cell | 5 studies | 44% ± 24% | |
type I pneumocyte | 5 studies | 33% ± 11% | |
type II pneumocyte | 5 studies | 34% ± 9% | |
lymphocyte | 4 studies | 38% ± 21% | |
Mueller cell | 4 studies | 43% ± 18% | |
amacrine cell | 4 studies | 26% ± 10% | |
retinal cone cell | 4 studies | 29% ± 13% | |
retinal rod cell | 4 studies | 29% ± 9% | |
club cell | 4 studies | 37% ± 11% | |
GABAergic interneuron | 3 studies | 27% ± 7% | |
granule cell | 3 studies | 31% ± 8% | |
progenitor cell | 3 studies | 38% ± 6% | |
plasma cell | 3 studies | 30% ± 9% | |
CD16-negative, CD56-bright natural killer cell, human | 3 studies | 26% ± 6% | |
CD8-positive, alpha-beta T cell | 3 studies | 23% ± 4% | |
effector memory CD8-positive, alpha-beta T cell | 3 studies | 23% ± 5% | |
vein endothelial cell | 3 studies | 41% ± 26% | |
GABAergic amacrine cell | 3 studies | 32% ± 12% | |
glycinergic amacrine cell | 3 studies | 26% ± 8% | |
retina horizontal cell | 3 studies | 32% ± 11% | |
endothelial cell of vascular tree | 3 studies | 41% ± 23% | |
hepatocyte | 3 studies | 60% ± 19% | |
ependymal cell | 3 studies | 43% ± 19% | |
alveolar macrophage | 3 studies | 39% ± 12% | |
capillary endothelial cell | 3 studies | 31% ± 5% | |
natural killer cell | 3 studies | 35% ± 5% | |
respiratory goblet cell | 3 studies | 42% ± 17% | |
leukocyte | 3 studies | 52% ± 7% | |
mesothelial cell | 3 studies | 37% ± 5% | |
mural cell | 3 studies | 44% ± 18% | |
mucus secreting cell | 3 studies | 40% ± 12% | |
regulatory T cell | 3 studies | 22% ± 6% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 1843.24 | 1445 / 1445 | 100% | 6.73 | 183 / 183 |
ovary | 100% | 3623.12 | 180 / 180 | 99% | 4.36 | 427 / 430 |
lung | 100% | 2362.47 | 578 / 578 | 99% | 5.25 | 1146 / 1155 |
intestine | 100% | 2174.89 | 966 / 966 | 99% | 4.33 | 522 / 527 |
breast | 100% | 2449.15 | 459 / 459 | 99% | 7.71 | 1106 / 1118 |
stomach | 100% | 2100.14 | 359 / 359 | 98% | 5.38 | 281 / 286 |
thymus | 100% | 2396.81 | 653 / 653 | 98% | 5.39 | 593 / 605 |
uterus | 100% | 3471.62 | 170 / 170 | 98% | 6.63 | 448 / 459 |
pancreas | 100% | 1302.43 | 327 / 328 | 98% | 4.29 | 174 / 178 |
prostate | 100% | 1815.70 | 245 / 245 | 96% | 5.38 | 484 / 502 |
bladder | 100% | 2140.48 | 21 / 21 | 95% | 4.62 | 478 / 504 |
brain | 95% | 1022.26 | 2508 / 2642 | 99% | 3.88 | 699 / 705 |
skin | 100% | 2851.77 | 1809 / 1809 | 92% | 3.57 | 432 / 472 |
kidney | 100% | 1214.85 | 89 / 89 | 91% | 3.49 | 820 / 901 |
adrenal gland | 100% | 1819.64 | 258 / 258 | 87% | 2.72 | 201 / 230 |
liver | 100% | 1161.50 | 225 / 226 | 78% | 2.44 | 318 / 406 |
adipose | 100% | 2035.62 | 1204 / 1204 | 0% | 0 | 0 / 0 |
spleen | 100% | 2530.18 | 241 / 241 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 1871.18 | 1334 / 1335 | 0% | 0 | 0 / 0 |
muscle | 100% | 1549.24 | 800 / 803 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 98% | 5.27 | 44 / 45 |
peripheral blood | 97% | 2046.63 | 899 / 929 | 0% | 0 | 0 / 0 |
heart | 93% | 1024.41 | 800 / 861 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 79% | 3.25 | 23 / 29 |
eye | 0% | 0 | 0 / 0 | 65% | 1.63 | 52 / 80 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0010468 | Biological process | regulation of gene expression |
GO_0006338 | Biological process | chromatin remodeling |
GO_0007507 | Biological process | heart development |
GO_0035097 | Cellular component | histone methyltransferase complex |
GO_0005654 | Cellular component | nucleoplasm |
GO_0044666 | Cellular component | MLL3/4 complex |
GO_0005634 | Cellular component | nucleus |
GO_0031490 | Molecular function | chromatin DNA binding |
GO_0032452 | Molecular function | histone demethylase activity |
GO_0071558 | Molecular function | histone H3K27me2/H3K27me3 demethylase activity |
GO_0000978 | Molecular function | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
GO_0005515 | Molecular function | protein binding |
GO_0046872 | Molecular function | metal ion binding |
Gene name | KDM6A |
Protein name | [histone H3]-trimethyl-L-lysine(27) demethylase (EC 1.14.11.68) Lysine-specific demethylase 6A (EC 1.14.11.68) (Histone demethylase UTX) (Ubiquitously-transcribed TPR protein on the X chromosome) (Ubiquitously-transcribed X chromosome tetratricopeptide repeat protein) ([histone H3]-trimethyl-L-lysine(27) demethylase 6A) Lysine demethylase 6A |
Synonyms | UTX |
Description | FUNCTION: Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code . Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-27' . Plays a central role in regulation of posterior development, by regulating HOX gene expression . Demethylation of 'Lys-27' of histone H3 is concomitant with methylation of 'Lys-4' of histone H3, and regulates the recruitment of the PRC1 complex and monoubiquitination of histone H2A . Plays a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression (By similarity). . |
Accessions | ENST00000675577.1 ENST00000674659.1 ENST00000536777.6 ENST00000611820.5 ENST00000431196.3 F5H6S1 A0A6Q8PHJ0 ENST00000676085.1 ENST00000674586.1 ENST00000674564.1 A0A6Q8PFK0 H0Y6V5 O15550 A0A6Q8PFD0 F8W8R6 A0A087WUN6 ENST00000674541.1 A0A6Q8PG32 ENST00000676062.1 A0A6Q8PHB6 A0A804HIZ7 ENST00000674867.1 A0A6Q8PG92 ENST00000683425.1 ENST00000683021.1 ENST00000684352.1 A0A6Q8PGN0 A0A6Q8PGG6 ENST00000675514.1 ENST00000621147.5 ENST00000377967.9 A0A804HJA2 ENST00000676133.1 A0A804HLJ3 F5H5V6 ENST00000543216.6 ENST00000676343.1 ENST00000682908.1 ENST00000382899.9 A0A6Q8PH94 A0A087X0R0 |