IL10RA | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
macrophage	35 studies	31% ± 13%	Explore
natural killer cell	30 studies	27% ± 9%	Explore
CD8-positive, alpha-beta T cell	28 studies	27% ± 10%	Explore
regulatory T cell	25 studies	37% ± 15%	Explore
conventional dendritic cell	24 studies	26% ± 10%	Explore
classical monocyte	24 studies	34% ± 12%	Explore
T cell	21 studies	24% ± 9%	Explore
non-classical monocyte	21 studies	42% ± 12%	Explore
monocyte	20 studies	30% ± 9%	Explore
CD4-positive, alpha-beta T cell	20 studies	26% ± 6%	Explore
plasmacytoid dendritic cell	17 studies	27% ± 8%	Explore
dendritic cell	16 studies	33% ± 17%	Explore
mature NK T cell	16 studies	30% ± 8%	Explore
B cell	15 studies	22% ± 6%	Explore
CD16-positive, CD56-dim natural killer cell, human	15 studies	32% ± 9%	Explore
gamma-delta T cell	15 studies	30% ± 8%	Explore
CD16-negative, CD56-bright natural killer cell, human	14 studies	33% ± 10%	Explore
effector memory CD8-positive, alpha-beta T cell	13 studies	33% ± 11%	Explore
memory B cell	13 studies	21% ± 6%	Explore
CD8-positive, alpha-beta memory T cell	12 studies	32% ± 8%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	12 studies	21% ± 3%	Explore
mucosal invariant T cell	11 studies	29% ± 8%	Explore
myeloid cell	10 studies	29% ± 7%	Explore
CD4-positive, alpha-beta memory T cell	10 studies	28% ± 6%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	9 studies	27% ± 8%	Explore
microglial cell	8 studies	27% ± 10%	Explore
leukocyte	7 studies	23% ± 4%	Explore
mononuclear phagocyte	7 studies	28% ± 13%	Explore
effector CD8-positive, alpha-beta T cell	6 studies	26% ± 7%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	34% ± 11%	Explore
exhausted T cell	5 studies	37% ± 8%	Explore
innate lymphoid cell	5 studies	29% ± 10%	Explore
effector CD4-positive, alpha-beta T cell	5 studies	32% ± 9%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	34% ± 10%	Explore
CD4-positive helper T cell	4 studies	22% ± 3%	Explore
central memory CD8-positive, alpha-beta T cell	4 studies	30% ± 16%	Explore
naive B cell	4 studies	21% ± 5%	Explore
lymphocyte	4 studies	25% ± 6%	Explore
plasmablast	4 studies	20% ± 4%	Explore
intermediate monocyte	4 studies	43% ± 23%	Explore
T follicular helper cell	4 studies	24% ± 7%	Explore
CD4-positive, alpha-beta cytotoxic T cell	3 studies	26% ± 6%	Explore
plasma cell	3 studies	24% ± 4%	Explore
tissue-resident macrophage	3 studies	36% ± 12%	Explore
monocyte-derived dendritic cell	3 studies	21% ± 4%	Explore
neutrophil	3 studies	26% ± 5%	Explore
T-helper 17 cell	3 studies	19% ± 3%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	31% ± 12%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	17 studies	29% ± 9%	Explore
lung	3 studies	23% ± 2%	Explore
lymph node	3 studies	20% ± 3%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
lung	100%	4316.58	578 / 578	92%	14.70	1061 / 1155
breast	93%	1458.56	425 / 459	90%	11.92	1004 / 1118
thymus	88%	1106.48	573 / 653	85%	8.48	512 / 605
intestine	98%	2537.71	944 / 966	68%	7.06	357 / 527
stomach	89%	993.30	321 / 359	74%	9.16	212 / 286
bladder	100%	1451.95	21 / 21	63%	7.09	317 / 504
esophagus	84%	979.45	1220 / 1445	70%	6.29	129 / 183
prostate	88%	1138.99	216 / 245	63%	4.44	315 / 502
uterus	76%	663.62	130 / 170	72%	6.80	329 / 459
kidney	56%	809.21	50 / 89	88%	17.04	794 / 901
adrenal gland	95%	1585.78	246 / 258	43%	2.92	98 / 230
skin	53%	442.54	963 / 1809	79%	15.18	375 / 472
pancreas	30%	246.83	97 / 328	92%	12.57	163 / 178
liver	61%	551.19	138 / 226	57%	4.81	230 / 406
brain	35%	318.95	937 / 2642	81%	10.24	573 / 705
ovary	41%	347.28	74 / 180	67%	5.79	286 / 430
lymph node	0%	0	0 / 0	100%	77.13	29 / 29
spleen	100%	15089.54	241 / 241	0%	0	0 / 0
peripheral blood	100%	7874.50	928 / 929	0%	0	0 / 0
adipose	99%	2755.14	1193 / 1204	0%	0	0 / 0
tonsil	0%	0	0 / 0	89%	14.47	40 / 45
blood vessel	87%	1320.08	1159 / 1335	0%	0	0 / 0
heart	60%	516.60	513 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	28%	2.48	22 / 80
muscle	11%	68.88	89 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0010507	Biological process	negative regulation of autophagy
GO_0140105	Biological process	interleukin-10-mediated signaling pathway
GO_0019221	Biological process	cytokine-mediated signaling pathway
GO_0050807	Biological process	regulation of synapse organization
GO_0050728	Biological process	negative regulation of inflammatory response
GO_0060729	Biological process	intestinal epithelial structure maintenance
GO_0046427	Biological process	positive regulation of receptor signaling pathway via JAK-STAT
GO_0070086	Biological process	ubiquitin-dependent endocytosis
GO_0032496	Biological process	response to lipopolysaccharide
GO_0016324	Cellular component	apical plasma membrane
GO_0005829	Cellular component	cytosol
GO_0005886	Cellular component	plasma membrane
GO_0019969	Molecular function	interleukin-10 binding
GO_0038023	Molecular function	signaling receptor activity
GO_0004920	Molecular function	interleukin-10 receptor activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	IL10RA
Protein name	Interleukin-10 receptor subunit alpha (IL-10 receptor subunit alpha) (IL-10R subunit alpha) (IL-10RA) (CDw210a) (Interleukin-10 receptor subunit 1) (IL-10R subunit 1) (IL-10R1) (CD antigen CD210) Interleukin 10 alpha receptor Interleukin 10 receptor subunit alpha
Synonyms	IL10R
Description	FUNCTION: Cell surface receptor for the cytokine IL10 that participates in IL10-mediated anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Upon binding to IL10, induces a conformational change in IL10RB, allowing IL10RB to bind IL10 as well . In turn, the heterotetrameric assembly complex, composed of two subunits of IL10RA and IL10RB, activates the kinases JAK1 and TYK2 that are constitutively associated with IL10RA and IL10RB respectively . These kinases then phosphorylate specific tyrosine residues in the intracellular domain in IL10RA leading to the recruitment and subsequent phosphorylation of STAT3. Once phosphorylated, STAT3 homodimerizes, translocates to the nucleus and activates the expression of anti-inflammatory genes. In addition, IL10RA-mediated activation of STAT3 inhibits starvation-induced autophagy . .
Accessions	ENST00000526544.5 ENST00000227752.8 Q13651 ENST00000534574.5 E9PPU4 H2DF05 E9PKU2

IL10RA report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review