HSD17B10 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0008209Biological processandrogen metabolic process
GO_0062173Biological processbrexanolone metabolic process
GO_1990180Biological processmitochondrial tRNA 3'-end processing
GO_0070901Biological processmitochondrial tRNA methylation
GO_0006550Biological processisoleucine catabolic process
GO_0006631Biological processfatty acid metabolic process
GO_0008207Biological processC21-steroid hormone metabolic process
GO_0007005Biological processmitochondrion organization
GO_0097745Biological processmitochondrial tRNA 5'-end processing
GO_0008210Biological processestrogen metabolic process
GO_0006635Biological processfatty acid beta-oxidation
GO_0006699Biological processbile acid biosynthetic process
GO_0006629Biological processlipid metabolic process
GO_0051289Biological processprotein homotetramerization
GO_0005886Cellular componentplasma membrane
GO_0042645Cellular componentmitochondrial nucleoid
GO_0005739Cellular componentmitochondrion
GO_0043527Cellular componenttRNA methyltransferase complex
GO_0030678Cellular componentmitochondrial ribonuclease P complex
GO_0005759Cellular componentmitochondrial matrix
GO_0005737Cellular componentcytoplasm
GO_0003857Molecular function3-hydroxyacyl-CoA dehydrogenase activity
GO_0047044Molecular functionandrostan-3-alpha,17-beta-diol dehydrogenase activity
GO_0106283Molecular functionursodeoxycholate 7-beta-dehydrogenase (NAD+) activity
GO_0106281Molecular functionchenodeoxycholate 7-alpha-dehydrogenase (NAD+) activity
GO_0106282Molecular functionisoursodeoxycholate 7-beta-dehydrogenase (NAD+) activity
GO_0047035Molecular functiontestosterone dehydrogenase (NAD+) activity
GO_0004303Molecular functionestradiol 17-beta-dehydrogenase [NAD(P)+] activity
GO_0030283Molecular functiontestosterone dehydrogenase [NAD(P)+] activity
GO_0047015Molecular function3-hydroxy-2-methylbutyryl-CoA dehydrogenase activity
GO_0008709Molecular functioncholate 7-alpha-dehydrogenase activity
GO_0044594Molecular function17-beta-hydroxysteroid dehydrogenase (NAD+) activity
GO_0003723Molecular functionRNA binding
GO_0000049Molecular functiontRNA binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameHSD17B10
Protein nameHydroxysteroid 17-beta dehydrogenase 10
Epididymis secretory sperm binding protein (Hydroxysteroid dehydrogenase 10 isoform 1)
Hydroxysteroid (17-beta) dehydrogenase 10 (Hydroxysteroid 17-beta dehydrogenase 10)
Hydroxysteroid dehydrogenase 10 isoform 2
3-hydroxyacyl-CoA dehydrogenase type-2 (EC 1.1.1.35) (17-beta-estradiol 17-dehydrogenase) (EC 1.1.1.62) (2-methyl-3-hydroxybutyryl-CoA dehydrogenase) (MHBD) (3-alpha-(17-beta)-hydroxysteroid dehydrogenase (NAD(+))) (EC 1.1.1.239) (3-hydroxy-2-methylbutyryl-CoA dehydrogenase) (EC 1.1.1.178) (3-hydroxyacyl-CoA dehydrogenase type II) (3alpha(or 20beta)-hydroxysteroid dehydrogenase) (EC 1.1.1.53) (7-alpha-hydroxysteroid dehydrogenase) (EC 1.1.1.159) (Endoplasmic reticulum-associated amyloid beta-peptide-binding protein) (Mitochondrial ribonuclease P protein 2) (Mitochondrial RNase P protein 2) (Short chain dehydrogenase/reductase family 5C member 1) (Short-chain type dehydrogenase/reductase XH98G2) (Type II HADH)
SynonymsRP3-339A18.2-004
XH98G2
HADH2
MRPP2
SDR5C1
SCHAD
ERAB
DescriptionFUNCTION: Mitochondrial dehydrogenase involved in pathways of fatty acid, branched-chain amino acid and steroid metabolism . Acts as (S)-3-hydroxyacyl-CoA dehydrogenase in mitochondrial fatty acid beta-oxidation, a major degradation pathway of fatty acids. Catalyzes the third step in the beta-oxidation cycle, namely the reversible conversion of (S)-3-hydroxyacyl-CoA to 3-ketoacyl-CoA. Preferentially accepts straight medium- and short-chain acyl-CoA substrates with highest efficiency for (3S)-hydroxybutanoyl-CoA . Acts as 3-hydroxy-2-methylbutyryl-CoA dehydrogenase in branched-chain amino acid catabolic pathway. Catalyzes the oxidation of 3-hydroxy-2-methylbutanoyl-CoA into 2-methyl-3-oxobutanoyl-CoA, a step in isoleucine degradation pathway . Has hydroxysteroid dehydrogenase activity toward steroid hormones and bile acids. Catalyzes the oxidation of 3alpha-, 17beta-, 20beta- and 21-hydroxysteroids and 7alpha- and 7beta-hydroxy bile acids . Oxidizes allopregnanolone/brexanolone at the 3alpha-hydroxyl group, which is known to be critical for the activation of gamma-aminobutyric acid receptors (GABAARs) chloride channel . Has phospholipase C-like activity toward cardiolipin and its oxidized species. Likely oxidizes the 2'-hydroxyl in the head group of cardiolipin to form a ketone intermediate that undergoes nucleophilic attack by water and fragments into diacylglycerol, dihydroxyacetone and orthophosphate. Has higher affinity for cardiolipin with oxidized fatty acids and may degrade these species during the oxidative stress response to protect cells from apoptosis . By interacting with intracellular amyloid-beta, it may contribute to the neuronal dysfunction associated with Alzheimer disease (AD) . Essential for structural and functional integrity of mitochondria . .; FUNCTION: In addition to mitochondrial dehydrogenase activity, moonlights as a component of mitochondrial ribonuclease P, a complex that cleaves tRNA molecules in their 5'-ends . Together with TRMT10C/MRPP1, forms a subcomplex of the mitochondrial ribonuclease P, named MRPP1-MRPP2 subcomplex, which displays functions that are independent of the ribonuclease P activity . The MRPP1-MRPP2 subcomplex catalyzes the formation of N(1)-methylguanine and N(1)-methyladenine at position 9 (m1G9 and m1A9, respectively) in tRNAs; HSD17B10/MRPP2 acting as a non-catalytic subunit . The MRPP1-MRPP2 subcomplex also acts as a tRNA maturation platform: following 5'-end cleavage by the mitochondrial ribonuclease P complex, the MRPP1-MRPP2 subcomplex enhances the efficiency of 3'-processing catalyzed by ELAC2, retains the tRNA product after ELAC2 processing and presents the nascent tRNA to the mitochondrial CCA tRNA nucleotidyltransferase TRNT1 enzyme . Associates with mitochondrial DNA complexes at the nucleoids to initiate RNA processing and ribosome assembly. .

AccessionsQ5H928
ENST00000168216.11 [Q99714-1]
ENST00000375304.9 [Q99714-2]
A0A804HHW5
A0A0S2Z434
A0A0S2Z410
ENST00000375298.4
Q99714
ENST00000684692.1