GTF2B report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006366Biological processtranscription by RNA polymerase II
GO_1904798Biological processpositive regulation of core promoter binding
GO_1990114Biological processRNA polymerase II core complex assembly
GO_0051123Biological processRNA polymerase II preinitiation complex assembly
GO_0006338Biological processchromatin remodeling
GO_0051177Biological processmeiotic sister chromatid cohesion
GO_0051225Biological processspindle assembly
GO_0019083Biological processviral transcription
GO_0006367Biological processtranscription initiation at RNA polymerase II promoter
GO_0006473Biological processprotein acetylation
GO_0001174Biological processtranscriptional start site selection at RNA polymerase II promoter
GO_0032993Cellular componentprotein-DNA complex
GO_0032153Cellular componentcell division site
GO_0042585Cellular componentgerminal vesicle
GO_0000776Cellular componentkinetochore
GO_0005669Cellular componenttranscription factor TFIID complex
GO_0005654Cellular componentnucleoplasm
GO_0097550Cellular componenttranscription preinitiation complex
GO_0090575Cellular componentRNA polymerase II transcription regulator complex
GO_0016604Cellular componentnuclear body
GO_0005694Cellular componentchromosome
GO_0005634Cellular componentnucleus
GO_0046966Molecular functionnuclear thyroid hormone receptor binding
GO_0017025Molecular functionTBP-class protein binding
GO_1990841Molecular functionpromoter-specific chromatin binding
GO_0140297Molecular functionDNA-binding transcription factor binding
GO_0000993Molecular functionRNA polymerase II complex binding
GO_0016407Molecular functionacetyltransferase activity
GO_0008270Molecular functionzinc ion binding
GO_0004402Molecular functionhistone acetyltransferase activity
GO_0016251Molecular functionRNA polymerase II general transcription initiation factor activity
GO_0005515Molecular functionprotein binding
GO_0000979Molecular functionRNA polymerase II core promoter sequence-specific DNA binding

IV. Literature review

[source]
Gene nameGTF2B
Protein nameTranscription initiation factor IIB (EC 2.3.1.48) (General transcription factor TFIIB) (S300-II)
Transcription initiation factor IIB (EC 2.3.1.48) (General transcription factor TFIIB)
SynonymsTF2B
TFIIB
DescriptionFUNCTION: General transcription factor that plays a role in transcription initiation by RNA polymerase II (Pol II). Involved in the pre-initiation complex (PIC) formation and Pol II recruitment at promoter DNA . Together with the TATA box-bound TBP forms the core initiation complex and provides a bridge between TBP and the Pol II-TFIIF complex . Released from the PIC early following the onset of transcription during the initiation and elongation transition and reassociates with TBP during the next transcription cycle . Associates with chromatin to core promoter-specific regions . Binds to two distinct DNA core promoter consensus sequence elements in a TBP-independent manner; these IIB-recognition elements (BREs) are localized immediately upstream (BREu), 5'-[GC][GC][GA]CGCC-3', and downstream (BREd), 5'-[GA]T[TGA][TG][GT][TG][TG]-3', of the TATA box element . Modulates transcription start site selection . Exhibits also autoacetyltransferase activity that contributes to the activated transcription . .

AccessionsENST00000370500.10
B1APE2
B1APE1
ENST00000418217.1
ENST00000448623.5
Q00403