GORASP2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0070925Biological processorganelle assembly
GO_0007030Biological processGolgi organization
GO_0007283Biological processspermatogenesis
GO_0061951Biological processestablishment of protein localization to plasma membrane
GO_0030154Biological processcell differentiation
GO_0006996Biological processorganelle organization
GO_0034976Biological processresponse to endoplasmic reticulum stress
GO_0000139Cellular componentGolgi membrane
GO_0005801Cellular componentcis-Golgi network
GO_0005794Cellular componentGolgi apparatus
GO_0016020Cellular componentmembrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameGORASP2
Protein nameGolgi reassembly stacking protein 2
Golgi reassembly-stacking protein 2 (GRS2) (Golgi phosphoprotein 6) (GOLPH6) (Golgi reassembly-stacking protein of 55 kDa) (GRASP55) (p59)
SynonymsGOLPH6
DescriptionFUNCTION: Key structural protein of the Golgi apparatus . The membrane cisternae of the Golgi apparatus adhere to each other to form stacks, which are aligned side by side to form the Golgi ribbon . Acting in concert with GORASP1/GRASP65, is required for the formation and maintenance of the Golgi ribbon, and may be dispensable for the formation of stacks . However, other studies suggest that GORASP2 plays a role in the assembly and membrane stacking of the Golgi cisternae, and in the process by which Golgi stacks reform after breakdown during mitosis and meiosis . May regulate the intracellular transport and presentation of a defined set of transmembrane proteins, such as transmembrane TGFA . Required for normal acrosome formation during spermiogenesis and normal male fertility, probably by promoting colocalization of JAM2 and JAM3 at contact sites between germ cells and Sertoli cells (By similarity). Mediates ER stress-induced unconventional (ER/Golgi-independent) trafficking of core-glycosylated CFTR to cell membrane . .

AccessionsQ9H8Y8
ENST00000444801.5
ENST00000442798.5
F8WEG2
ENST00000454751.5
F8WEH9
F8WF79
F8WBR9
ENST00000455067.5
ENST00000234160.5 [Q9H8Y8-1]