GBP2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0051715Biological processcytolysis in another organism
GO_0140639Biological processpositive regulation of pyroptotic inflammatory response
GO_0140973Biological processpositive regulation of AIM2 inflammasome complex assembly
GO_0042832Biological processdefense response to protozoan
GO_0051607Biological processdefense response to virus
GO_0071347Biological processcellular response to interleukin-1
GO_0006955Biological processimmune response
GO_0071356Biological processcellular response to tumor necrosis factor
GO_0050830Biological processdefense response to Gram-positive bacterium
GO_0034504Biological processprotein localization to nucleus
GO_0042742Biological processdefense response to bacterium
GO_0002218Biological processactivation of innate immune response
GO_0071222Biological processcellular response to lipopolysaccharide
GO_0071346Biological processcellular response to type II interferon
GO_0031410Cellular componentcytoplasmic vesicle
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0005654Cellular componentnucleoplasm
GO_0005794Cellular componentGolgi apparatus
GO_0000139Cellular componentGolgi membrane
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0030659Cellular componentcytoplasmic vesicle membrane
GO_0005634Cellular componentnucleus
GO_0042803Molecular functionprotein homodimerization activity
GO_0004866Molecular functionendopeptidase inhibitor activity
GO_0042802Molecular functionidentical protein binding
GO_0005525Molecular functionGTP binding
GO_0005515Molecular functionprotein binding
GO_0140678Molecular functionmolecular function inhibitor activity
GO_0003924Molecular functionGTPase activity

IV. Literature review

[source]
Gene nameGBP2
Protein nameGuanylate-binding protein 2
GBP2 protein
Guanylate-binding protein 2 (EC 3.6.5.-) (GTP-binding protein 2) (GBP-2) (HuGBP-2) (Guanine nucleotide-binding protein 2) (Interferon-induced guanylate-binding protein 2)
Synonyms
DescriptionFUNCTION: Interferon (IFN)-inducible GTPase that plays important roles in innate immunity against a diverse range of bacterial, viral and protozoan pathogens . Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions, but the major reaction product is GDP . Following infection, recruited to the pathogen-containing vacuoles or vacuole-escaped bacteria and acts as a positive regulator of inflammasome assembly by promoting the release of inflammasome ligands from bacteria (By similarity). Acts by promoting lysis of pathogen-containing vacuoles, releasing pathogens into the cytosol (By similarity). Following pathogen release in the cytosol, promotes recruitment of proteins that mediate bacterial cytolysis: this liberates ligands that are detected by inflammasomes, such as lipopolysaccharide (LPS) that activates the non-canonical CASP4/CASP11 inflammasome or double-stranded DNA (dsDNA) that activates the AIM2 inflammasome (By similarity). Confers protection to the protozoan pathogen Toxoplasma gondii (By similarity). Independently of its GTPase activity, acts as an inhibitor of various viruses infectivity, such as HIV-1, Zika and influenza A viruses, by inhibiting FURIN-mediated maturation of viral envelope proteins . .

AccessionsENST00000370466.4
P32456
A0A348GSI7
Q8TCE5
ENST00000464839.5