Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
ovary | 100% | 6615.73 | 180 / 180 | 100% | 111.11 | 430 / 430 |
prostate | 100% | 6197.62 | 245 / 245 | 100% | 146.08 | 501 / 502 |
breast | 100% | 4790.05 | 459 / 459 | 100% | 222.85 | 1115 / 1118 |
uterus | 100% | 5067.94 | 170 / 170 | 99% | 111.89 | 455 / 459 |
skin | 100% | 6310.44 | 1808 / 1809 | 99% | 89.45 | 467 / 472 |
bladder | 100% | 6858.19 | 21 / 21 | 99% | 106.78 | 498 / 504 |
brain | 99% | 7004.71 | 2615 / 2642 | 100% | 60.26 | 702 / 705 |
intestine | 100% | 4712.66 | 966 / 966 | 98% | 112.10 | 517 / 527 |
pancreas | 100% | 4258.01 | 328 / 328 | 98% | 73.02 | 174 / 178 |
stomach | 100% | 6355.85 | 359 / 359 | 98% | 89.48 | 279 / 286 |
thymus | 100% | 6487.32 | 653 / 653 | 97% | 58.70 | 586 / 605 |
esophagus | 100% | 6192.24 | 1444 / 1445 | 97% | 80.39 | 177 / 183 |
lung | 99% | 5509.67 | 571 / 578 | 95% | 87.31 | 1098 / 1155 |
liver | 100% | 4537.57 | 225 / 226 | 93% | 53.04 | 378 / 406 |
kidney | 100% | 7291.72 | 89 / 89 | 92% | 46.36 | 833 / 901 |
adrenal gland | 100% | 5361.09 | 258 / 258 | 87% | 51.60 | 200 / 230 |
tonsil | 0% | 0 | 0 / 0 | 100% | 116.76 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 47.12 | 1 / 1 |
muscle | 100% | 6126.77 | 802 / 803 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 5013.76 | 1331 / 1335 | 0% | 0 | 0 / 0 |
spleen | 99% | 3530.51 | 239 / 241 | 0% | 0 | 0 / 0 |
adipose | 99% | 4180.67 | 1194 / 1204 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 98% | 84.73 | 78 / 80 |
lymph node | 0% | 0 | 0 / 0 | 97% | 56.75 | 28 / 29 |
heart | 95% | 3622.09 | 814 / 861 | 0% | 0 | 0 / 0 |
peripheral blood | 74% | 4133.18 | 692 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0006825 | Biological process | copper ion transport |
GO_0061077 | Biological process | chaperone-mediated protein folding |
GO_0031115 | Biological process | negative regulation of microtubule polymerization |
GO_0046661 | Biological process | male sex differentiation |
GO_0030850 | Biological process | prostate gland development |
GO_0031111 | Biological process | negative regulation of microtubule polymerization or depolymerization |
GO_0006457 | Biological process | protein folding |
GO_0010977 | Biological process | negative regulation of neuron projection development |
GO_0006463 | Biological process | steroid hormone receptor complex assembly |
GO_0030521 | Biological process | androgen receptor signaling pathway |
GO_0007566 | Biological process | embryo implantation |
GO_0031503 | Biological process | protein-containing complex localization |
GO_0000413 | Biological process | protein peptidyl-prolyl isomerization |
GO_0005874 | Cellular component | microtubule |
GO_0048471 | Cellular component | perinuclear region of cytoplasm |
GO_0005739 | Cellular component | mitochondrion |
GO_0070062 | Cellular component | extracellular exosome |
GO_0032991 | Cellular component | protein-containing complex |
GO_0005654 | Cellular component | nucleoplasm |
GO_0043025 | Cellular component | neuronal cell body |
GO_0005829 | Cellular component | cytosol |
GO_0044295 | Cellular component | axonal growth cone |
GO_0005737 | Cellular component | cytoplasm |
GO_0032767 | Molecular function | copper-dependent protein binding |
GO_0035259 | Molecular function | nuclear glucocorticoid receptor binding |
GO_0003755 | Molecular function | peptidyl-prolyl cis-trans isomerase activity |
GO_0031072 | Molecular function | heat shock protein binding |
GO_0005525 | Molecular function | GTP binding |
GO_0030674 | Molecular function | protein-macromolecule adaptor activity |
GO_0005524 | Molecular function | ATP binding |
GO_0003723 | Molecular function | RNA binding |
GO_0048156 | Molecular function | tau protein binding |
GO_0005528 | Molecular function | FK506 binding |
GO_0051219 | Molecular function | phosphoprotein binding |
GO_0005515 | Molecular function | protein binding |
Gene name | FKBP4 |
Protein name | FKBPL (Peptidyl-prolyl cis-trans isomerase (EC 5.2.1.8)) Peptidyl-prolyl cis-trans isomerase FKBP4 (PPIase FKBP4) (EC 5.2.1.8) (51 kDa FK506-binding protein) (FKBP51) (52 kDa FK506-binding protein) (52 kDa FKBP) (FKBP-52) (59 kDa immunophilin) (p59) (FK506-binding protein 4) (FKBP-4) (FKBP59) (HSP-binding immunophilin) (HBI) (Immunophilin FKBP52) (Rotamase) [Cleaved into: Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed] FKBP prolyl isomerase 4 peptidylprolyl isomerase (EC 5.2.1.8) |
Synonyms | FKBP52 |
Description | FUNCTION: Immunophilin protein with PPIase and co-chaperone activities. Component of steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Acts also as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. May have a protective role against oxidative stress in mitochondria. . |
Accessions | ENST00000543769.1 A0A0F7G8H5 ENST00000538622.1 ENST00000539181.1 Q02790 ENST00000001008.6 F5H1U3 ENST00000544366.1 F5H120 ENST00000630279.1 H0YG86 H0YFG2 |