FKBP4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006825Biological processcopper ion transport
GO_0061077Biological processchaperone-mediated protein folding
GO_0031115Biological processnegative regulation of microtubule polymerization
GO_0046661Biological processmale sex differentiation
GO_0030850Biological processprostate gland development
GO_0031111Biological processnegative regulation of microtubule polymerization or depolymerization
GO_0006457Biological processprotein folding
GO_0010977Biological processnegative regulation of neuron projection development
GO_0006463Biological processsteroid hormone receptor complex assembly
GO_0030521Biological processandrogen receptor signaling pathway
GO_0007566Biological processembryo implantation
GO_0031503Biological processprotein-containing complex localization
GO_0000413Biological processprotein peptidyl-prolyl isomerization
GO_0005874Cellular componentmicrotubule
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0005739Cellular componentmitochondrion
GO_0070062Cellular componentextracellular exosome
GO_0032991Cellular componentprotein-containing complex
GO_0005654Cellular componentnucleoplasm
GO_0043025Cellular componentneuronal cell body
GO_0005829Cellular componentcytosol
GO_0044295Cellular componentaxonal growth cone
GO_0005737Cellular componentcytoplasm
GO_0032767Molecular functioncopper-dependent protein binding
GO_0035259Molecular functionnuclear glucocorticoid receptor binding
GO_0003755Molecular functionpeptidyl-prolyl cis-trans isomerase activity
GO_0031072Molecular functionheat shock protein binding
GO_0005525Molecular functionGTP binding
GO_0030674Molecular functionprotein-macromolecule adaptor activity
GO_0005524Molecular functionATP binding
GO_0003723Molecular functionRNA binding
GO_0048156Molecular functiontau protein binding
GO_0005528Molecular functionFK506 binding
GO_0051219Molecular functionphosphoprotein binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameFKBP4
Protein nameFKBPL (Peptidyl-prolyl cis-trans isomerase (EC 5.2.1.8))
Peptidyl-prolyl cis-trans isomerase FKBP4 (PPIase FKBP4) (EC 5.2.1.8) (51 kDa FK506-binding protein) (FKBP51) (52 kDa FK506-binding protein) (52 kDa FKBP) (FKBP-52) (59 kDa immunophilin) (p59) (FK506-binding protein 4) (FKBP-4) (FKBP59) (HSP-binding immunophilin) (HBI) (Immunophilin FKBP52) (Rotamase) [Cleaved into: Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed]
FKBP prolyl isomerase 4
peptidylprolyl isomerase (EC 5.2.1.8)
SynonymsFKBP52
DescriptionFUNCTION: Immunophilin protein with PPIase and co-chaperone activities. Component of steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Acts also as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. May have a protective role against oxidative stress in mitochondria. .

AccessionsENST00000543769.1
A0A0F7G8H5
ENST00000538622.1
ENST00000539181.1
Q02790
ENST00000001008.6
F5H1U3
ENST00000544366.1
F5H120
ENST00000630279.1
H0YG86
H0YFG2